Allodynia Hell

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YoYoFat said:
Been on Tirz since August 2024. Maintenance since late May/early June 2025. Dosing 8mg/week, split into two doses (once every 3.5 days). Haven’t increased my dose since February. Last two doses I used an old vial of Skye I got last September (not wasting that $$$ stuff!). Before that, I was exclusively using Nexa in 2025 with literally zero issues.

Allodynia arrived last week. Started on my inner thigh, moved to my mid-quad, and how is on my outer hip.

It’s MADDENING.

What is causing this and how do I make it go away other than just stopping the Tirz altogether?

Filler in the Skye vial?

Vitamin deficiencies from long term GLP-1 use? Which ones?

How long does it last?

Help me not lose my mind!
Can you get a prescription for Gabapentin or Topamax? I had to take it for epilepsy and migraine disorder in the past and know it’s used to combat nerve pain and fibromyalgia.

Topamax is prescribed off-label for weight loss because it makes you lose all interest in food (you just forget food is even a thing, it’s weird).
 
mopo89 said:
miss you too! i honestly kinda forgot about this place? life has been so busy and all i do is work and read and sleep.

ahh thanks for the offer! i am very deep in the dungeon crawler carl universe right now and don't want to ever leave.
 
Needsalife said:
Report back after you’ve taken the zinc a couple of days, please.
I took zinc for a week, didn’t really seem to affect it during that period.

I really think it was something in the vial I was using.

I had been using Nexaph for a year. I grabbed an older vial of Skye (from summer 2024, before I knew about kits) just to use it up. I dose 2x week. Day of the second dose from that vial, the allodynia came on. Once I switched back to Nexaph, it went away.

Could be just a coincidence. But as “they” say it’s common for allodynia to come on after increasing your dose, and I’d been on the same dose and vendor for several months, and turn online change was that one vial….
 
I've had it for about three weeks now. I had been fine on Reta 8mg for 8 weeks, but when I increased it to 10, I started noticing my skin getting sensitive. Same vendor, etc. and Hospira BAC. I stayed at 10, figuring it would go away. Here we are week 3, the day before my shot, and it's finally gone, but I worry it will return if I do 10 again tomorrow. Oh well, I'll do it for science.
 
I am afraid to tell you nothing I tried made it go away. I started getting it on 10mg of tirz and although I don’t have it all the time I do have it regularly. Been about a year.

It travels and will be in one patch and then move to a different area of the body. Feet, arms, legs, shoulders and under my arms are most common sites. It stopped only when I stopped taking tirz. When I switched to Reta split dosing seemed fine until I got to 6mg in one dose and then it was back. Less intense than it was on tirz but still there. Under my arm is burning, feels like sunburn at present moment.

I was taking vitamin supplements the whole time and still am and it made no difference for me. I also get injection site sensitivity but it goes away quicker with Reta than it did with tirz.

I do hope you find something that works for you
 
Everyone's body ADAPTS differently. What suits you best is the best. One's own physical health is the most important

Thistley said:
I am afraid to tell you nothing I tried made it go away. I started getting it on 10mg of tirz and although I don’t have it all the time I do have it regularly. Been about a year.

It travels and will be in one patch and then move to a different area of the body. Feet, arms, legs, shoulders and under my arms are most common sites. It stopped only when I stopped taking tirz. When I switched to Reta split dosing seemed fine until I got to 6mg in one dose and then it was back. Less intense than it was on tirz but still there. Under my arm is burning, feels like sunburn at present moment.

I was taking vitamin supplements the whole time and still am and it made no difference for me. I also get injection site sensitivity but it goes away quicker with Reta than it did with tirz.

I do hope you find something that works for you
 
Thankfully I only get allodynia if I have slightly more reta than usual. I have done a fair bit of research on what may help nerve pain as I have permanent cold and mildly painful toes, plus a bit of parasthesia from what I assume is an obesity caused peripheral neuropathy. PEA or palmitoylethanolamide is available from amazon and has a very large number of good quality human trials demonstrating it's effectiveness for nerve type pain and other pain types. Also alpha lipoic acid has fairly good evidence supporting its effectiveness as well for peripheral neuropathy pain.

If it is pretty annoying and stopping Tirzepatide for a while or lowering the dose is not a good option then either of these options are safe, reasonably cheap and probably as effective as any prescription medication ( at least PEA ) for that problem.

It could be worth considering swapping to semaglutide, at lower doses ( under 2.4mg/w ) skin sensation abnormalities were not common, but were very common in the much higher dose trials 9.6-16mg, Pretty sure it was more common with reta than tirzepatide.

The only vitamin deficiency that commonly causes those symptoms is vitamin b12 deficiency, but too much b6 or pyridoxine is a fairly common cause of neuropathy , anything above 50mg a day is a bad idea, less than 25 is probably safe.
 
lessthanhalf said:
Thankfully I only get allodynia if I have slightly more reta than usual. I have done a fair bit of research on what may help nerve pain as I have permanent cold and mildly painful toes, plus a bit of parasthesia from what I assume is an obesity caused peripheral neuropathy. PEA or palmitoylethanolamide is available from amazon and has a very large number of good quality human trials demonstrating it's effectiveness for nerve type pain and other pain types. Also alpha lipoic acid has fairly good evidence supporting its effectiveness as well for peripheral neuropathy pain.

If it is pretty annoying and stopping Tirzepatide for a while or lowering the dose is not a good option then either of these options are safe, reasonably cheap and probably as effective as any prescription medication ( at least PEA ) for that problem.

It could be worth considering swapping to semaglutide, at lower doses ( under 2.4mg/w ) skin sensation abnormalities were not common, but were very common in the much higher dose trials 9.6-16mg, Pretty sure it was more common with reta than tirzepatide.

The only vitamin deficiency that commonly causes those symptoms is vitamin b12 deficiency, but too much b6 or pyridoxine is a fairly common cause of neuropathy , anything above 50mg a day is a bad idea, less than 25 is probably safe.
I'm actually just trying PEA for this. I'm hoping it helps.
 
lessthanhalf said:
Thankfully I only get allodynia if I have slightly more reta than usual. I have done a fair bit of research on what may help nerve pain as I have permanent cold and mildly painful toes, plus a bit of parasthesia from what I assume is an obesity caused peripheral neuropathy. PEA or palmitoylethanolamide is available from amazon and has a very large number of good quality human trials demonstrating it's effectiveness for nerve type pain and other pain types. Also alpha lipoic acid has fairly good evidence supporting its effectiveness as well for peripheral neuropathy pain.

If it is pretty annoying and stopping Tirzepatide for a while or lowering the dose is not a good option then either of these options are safe, reasonably cheap and probably as effective as any prescription medication ( at least PEA ) for that problem.

It could be worth considering swapping to semaglutide, at lower doses ( under 2.4mg/w ) skin sensation abnormalities were not common, but were very common in the much higher dose trials 9.6-16mg, Pretty sure it was more common with reta than tirzepatide.

The only vitamin deficiency that commonly causes those symptoms is vitamin b12 deficiency, but too much b6 or pyridoxine is a fairly common cause of neuropathy , anything above 50mg a day is a bad idea, less than 25 is probably safe.
Great information considering I have neuropathy and I’m on Reta. Thank you
 
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