Add Reta or Cagri to Trz?

[When_Pigs_Fly]

Hi all. I’m wondering if we can get some more community

input on this topic than other posts have generated.

I got to 110 lbs. My GW. Then, although nothing else has changed, I gained 10 lb back. I’ve been fighting that last 10 lbs for several months (about 6). My tirz was maxed out at 15 mg. The food noise was pretty low. I went off Tirz for 3 weeks. Then went back to 10 mg Tirz. Then the following week I added 3 mg Reta. Bad idea. I was so nauseated. So I haven’t done more Reta. In reading more about the options to address my “stall” (or whatever you’d call it) - I want these new 10 lbs off!! - I am now wondering if I should add cagri not Reta? Should I increase my tirz again? Should I split the Reta or

Cagri into two doses?

Welcome all opinions. Pls help. Thank you in advance.

 

[Summer48]

I’m in the same position as you. Although I’m not gaining weight I’m not losing and it’s been the same for 4/5 months. Even tried 17.5mg and 20mg but nothing. Wanting to eat same as before starting tirz

I’ve got cagri and Reta but not sure which to use so any advise would be great. I’ve still got 12 lbs to lose

 

[Slogger]

I’m in a similar situation. Been on tirz since July 2025 and have been pinning 6mg every 5 days. I don’t feel stalled per se but this last 5 lbs is being stubborn. I could be ‘ok’ where I am but a goal is a goal and I’ve come this far and don’t like to give up. Yes, I could increase my tirz dose but my plan is to try to stay at a lower dose through maintenance once I reach my goal weight so my stockpile will last longer I’ve ordered 2 vials of Reta and plan to pin a very very low starting dose three days after my Tirz to test for adverse side effects and to see what it does. I debated going with sema but I am hoping the potential benefits (reduced blood pressure) of Reta will come into play for me. We shall see…I can’t start until my Reta arrives later this week.

 

[TooBigtoFail]

Hi all. I’m wondering if we can get some more community

input on this topic than other posts have generated.

I got to 110 lbs. My GW. Then, although nothing else has changed, I gained 10 lb back. I’ve been fighting that last 10 lbs for several months (about 6). My tirz was maxed out at 15 mg. The food noise was pretty low. I went off Tirz for 3 weeks. Then went back to 10 mg Tirz. Then the following week I added 3 mg Reta. Bad idea. I was so nauseated. So I haven’t done more Reta. In reading more about the options to address my “stall” (or whatever you’d call it) - I want these new 10 lbs off!! - I am now wondering if I should add cagri not Reta? Should I increase my tirz again? Should I split the Reta or

Cagri into two doses?

Welcome all opinions. Pls help. Thank you in advance.

You may have started Reta with too high a dose. I favor Cagri as it works on Amylin receptors, something Tirz or Reta do not touch. I pin on a 6 day cycle, 3 days offset each.

I started with Tirz ~20 months ago. Once I passed the 10mg mark, I added Cagri, low dosage. Slowly bumped tirz to 20mg/w. Cagri was painful on my stomach but it cut food craving by 100%. Then added Reta 0.5mg, and slowly increased. Titrated tirz down to 10mg/w. 6 mths later, I got off Cagri. Yes, all 3 at once for 6 mths. off tirz 6 mths later. Am down 92# and zigzagging with Cagri/Reta for those last 10-15 lbs. I did not see a difference in weight loss speed, pinning each pep, half dose, every 3 or 4 days (yes, a lot of injections per week). I have never stopped any of them abruptly, always titrating up or down over 4-6 weeks. Each time I hit a stall for 2-3 weeks, I changed something. Sema looks so weak compared to others (see pic below).

 

[retarequired]

I don't have personal experience with mixing glp1's together but I think it's probbly best to avoid it. The tirz is already hitting glp1 and gip, the only new thing you'd get from reta is the glucagon component, whether that's worth it or not I don't know for sure, but I'm leaning towards no.

Cagrilintide works through an entirely different mechanism, it's an amylin analogue, there is no overlap with tirz there. Because of this I think it would be a better idea to add that and skip the reta for now.

I think it's only worth looking at switching to reta, not adding it, if adding cagri to tirz fails.

 

[When_Pigs_Fly]

Thanks to all. This was super helpful to me. Any suggestions on where to find Cagri dosing info?

 

[msyntakz]

Just adding my two cents.

I have been on 2.5mg Tirz, and added 1mg Reta. The only changes I noticed were increased appetite suppression and better energy. I like the combo. It's true that they both hit GLP1 and GIP, but from the research I have done, Tirz and Reta do this in different ratios. If that is true, then Reta is not just Tirz plus Glucagon activation, which would line up with the reduced appetite suppression that many report on Reta Vs Tirz. Thus, my adventure in stacking.

I may actually back down my Tirz slightly in this combo, as currently it's rather strong. I suspect your jump in Reta may have just been a lot for your system initially. I haven't tried Cagri, but it's definitely something of interest. But for me, I am not going to fix what's not broken. All the best to you!

 

[TooBigtoFail]

Google

Thanks to all. This was super helpful to me. Any suggestions on where to find Cagri dosing info?

Google it. 'TheLancet' has the study starting with 0.3, 0.6, 1.2, 2.4mg, in 4 week increments.

I started at 0.16 (half of lowest) to minimize gastrointestinal side effects. That is just me playing it safe. I titrated up at much slower interval, like up by 0.1mg every few weeks. Now at 1.1mg every 6 days. It is working well for appetite suppression, so I am not titrating up these days.

 

[CariocaLeftSeoul]

Late for the convo, and my Tirz dosage is much lower than yours, but I broke a stall by adding reta, however much much slower than you. I do Tirz on Friday mornings and Reta on Monday nights, started with 0.5/week of reta, after two weeks, upped to 0.75, after 2 weeks went to 1mg, and that finally broke my stall.

 

[jaguar]

I’m in a similar situation. Been on tirz since July 2025 and have been pinning 6mg every 5 days. I don’t feel stalled per se but this last 5 lbs is being stubborn. I could be ‘ok’ where I am but a goal is a goal and I’ve come this far and don’t like to give up. Yes, I could increase my tirz dose but my plan is to try to stay at a lower dose through maintenance once I reach my goal weight so my stockpile will last longer I’ve ordered 2 vials of Reta and plan to pin a very very low starting dose three days after my Tirz to test for adverse side effects and to see what it does. I debated going with sema but I am hoping the potential benefits (reduced blood pressure) of Reta will come into play for me. We shall see…I can’t start until my Reta arrives later this week.

Did you end up what I would call 'microdosing' the reta with your tirz? How did that go for you? Very curious!!

 

[When_Pigs_Fly]

Did you end up what I would call 'microdosing' the reta with your tirz? How did that go for you? Very curious!!

So I’m only doing trz now. Reta made me have a lot of nausea and I stopped after a week. However, it’s important to note that I think I started too high. I am going to add Cagri. Just haven’t started it yet.

 

[domin8brix]

So I’m only doing trz now. Reta made me have a lot of nausea and I stopped after a week. However, it’s important to note that I think I started too high. I am going to add Cagri. Just haven’t started it yet.

Make sure you go SUPER DUPER LOW with Cagri. If you thought Reta made you feel gross, this stuff will make you ten times worse. I started at .5mg and regretted it immediately.

 

[indolent]

Sema looks so weak compared to others (see pic below).

It's counterintuitive, but on this chart a lower number indicates more binding affinity.

That's why reta isn't great at appetite suppression (high number for GLP-1), and why adding a whisper of semaglutide to a tirzepatide regimen is another option for breaking through returning food noise.

 

[jaguar]

So I’m only doing trz now. Reta made me have a lot of nausea and I stopped after a week. However, it’s important to note that I think I started too high. I am going to add Cagri. Just haven’t started it yet.

Not to be demanding, but...again, you must keep me informed! haha. I'm been considering adding Cagri, myself, just haven't committed or gotten the supply yet. Remember to come back here and let me know how its treating you. Do tell

 

[Grogu]

Not to be demanding, but...again, you must keep me informed! haha. I'm been considering adding Cagri, myself, just haven't committed or gotten the supply yet. Remember to come back here and let me know how its treating you. Do tell

I’m not the OP, but in very similar circumstance. I’ve been on tirzepatide for about 17 months and have titrated up to 18mg. I have about another 20 pounds to lose. So, about two weeks ago I pinned 4mg of reta and cut back on my tirzepatide dose. I think it must have been too much reta because I had a really bad case of constipation, lower abdominal pain, gas, and haven’t felt very good these past two weeks. And the food noise suppression wasn’t that great.

Looking back, I probably should have keep my tirzepatide dose the same and added a smaller stack of reta, maybe 2mg. Prior to trying reta, I tried cagri a few times and liked it, so I’m going to start that again today. I’m going to pin the 18mg of tirzepatide I would normally do today and pin .5mg of cagri. I haven’t given up on reta, but when I try again, I’m going to start at a lower dose.

 

[Dilbert4Life]

Late for the convo, and my Tirz dosage is much lower than yours, but I broke a stall by adding reta, however much much slower than you. I do Tirz on Friday mornings and Reta on Monday nights, started with 0.5/week of reta, after two weeks, upped to 0.75, after 2 weeks went to 1mg, and that finally broke my stall.

So you are now going to continue reta or stop and continue tirz only?

 

[lessthanhalf]

I did it backasswards losing the weight then starting GLP's, but when I got to 15mg of tirz with very minimal side effects after a year of nausea on ozempic, and I was still hungry, I did not want to stop tirz and switch to reta as it was working pretty well , so I just added reta 5mg, and much later added in cagri at 0.25 mg every 4 days. I was dosing smaller amounts every 2 days to minimise side effects, mainly because I had to do that with ozempic due to the nausea, so just stayed in that pattern out of habit mostly.

But that combination is working for me , I lost another 13 kilos or so to get to 65 kg after originally starting at 145kg, and losing most of it before starting them. But it is a huge weight loss to maintain , which is why the high doses and combos seem to be needed.

I was using 2nd daily doses which does make it much quicker and easier to adjust doses up and down , but it could just as easily be done with weekly doses but would be better done fairly slowly. I definitely noticed mild nausea from 0.25mg of cagri and spent a month or two trying to work out if I liked the slightly reduced hunger with slightly increased nausea or not.

Adding in reta again might be worth trying at a much lower dose, but logically low dose cagri probably makes more sense

 

[GrandmaJ]

I am adding this in case anyone searches for this in the future. (Ok, it's for me, I am likely to search for this again). Low and slow looks best.

Cagrilintide dosing escalation:

Week 1: 0.25mg

Week 2: 0.5mg

Week 3: 1.0mg

Week 4: 1.7mg

Week 5+: 2.4mg (maintenance)

Full escalation takes 16 weeks total. All doses are once weekly subcutaneous injection.