最低剂量？

[ahhamunster]

我目前每周注射一次1.5毫克Reta。除了周末感觉药效减弱外，其他方面几乎没有副作用。我看到很多人服用的剂量比我高得多，比如6毫克、8毫克，当然还有临床试验剂量。我的剂量是不是太低了？我是否应该随着药效减弱，每周逐渐增加剂量？我一直在考虑把剂量分成两份，每周注射两次，而不是一次注射全部剂量。我是新手，请多多包涵！

 

[cygnus]

慢慢来没关系；我妻子一开始服用的是0.5毫克，因为她担心潜在的副作用。如果你已经服用1.5毫克至少两周，那就增加到2毫克，持续两周，然后每两周增加0.5毫克，直到你感觉饥饿信号不再困扰你为止——例如，我周日晚上注射，如果周四开始感到饥饿，我就知道该再次增加剂量了。如果周六开始感到饥饿，我就保持相同的剂量。

考虑到血清浓度和信号峰值，我个人认为没有必要分次注射；分次注射更多是为了减轻一些副作用，而不是为了最大化肽的疗效。我宁愿看到有人每周一次性注射3毫克，而不是每3.5天注射两次1.5毫克（假设没有副作用），仅仅是因为3毫克会发出更强的信号。分次服用不会要你的命，也没什么错，我只是想简单介绍一下背景。

你保持耐心是好事。有耐心的人往往更容易获得长期的成功。考虑一下逐步增加剂量；如果你从较低剂量就能获益，就没必要急于找到没有副作用的最大剂量。

 

[Calm Logic]

我是新手，请多多包涵！

要么全力以赴，要么回家

！开玩笑啦。你服用reta减肥药后有减重吗？你服用GLP多久了？

我在你的自我介绍里找到了大部分答案：

[archived internal link]

我以前自然减过30磅，体重降到150磅（感觉棒极了，自信满满，心情愉悦），但生完孩子后体重又涨到了248磅，开始减肥时是223磅，现在是215磅。我的奶水充足。我希望能再次达到150磅，回到那种感觉良好的状态。

你睡在reta上还有睡眠问题吗？

 

[tubby]

There are different ways you can approach dosing:

One would be to establish a higher goal dose that you're trying to reach (e.g. maximize weight loss rate). Another would be to target dosage minimization (e.g. as long as you're still losing some weight stick to that dose).

The other (and probably most common method) of allowing perceived food noise and hunger signaling to guide you seems very intuitive, but comes with the risk that you're likely chasing after an unrealistic goal, similar to dosing a pain med until the pain is completely gone.

 

[ahhamunster]

GO BIG OR GO HOME

Just kidding. Have you lost any weight at all on reta yet? How long have you been on GLPs?

Found most of the answers in your intro:

[archived internal link]

Do you still have problems sleeping on reta?

YES. The first three nights after I pin, I sleep but feel do not feel rested whatsoever.

 

[tubby]

YES. The first three nights after I pin, I sleep but feel do not feel rested whatsoever.

Funny, I'm the exact opposite: I'll only be able to sleep 4-5 hours (although force myself to stay in bed a couple more hours), but then will feel fully rested. Although, I guess if you've got a newborn on your mind and I don't, so that could factor in too.

 

[ahhamunster]

It's okay to go slow; I started my wife at 0.5mg as she was concerned about potential side effects. If you've been on 1.5mg for at least a couple weeks, bump it to 2mg for two weeks and do the 0.5mg bump every two weeks until you feel like the hunger signaling isn't bothering you -- for example I pin Sunday evening and if I start to get hungry on Thursday, I know it's time to increase again. If I start to get hungry on Saturday, I stay at the same dose.

Due to serum concentration levels and signaling peaks, I don't personally think it is necessary to split your dose; dose splitting came into play more as a means to mitigate some of the side effects rather than maximizing effectiveness of the peptide. I would rather see someone doing 3mg in a single pin weekly than two 1.5mg every 3.5 days (assuming no side effects) just due to the 3mg sending a stronger signal. Splitting won't kill you, and there's nothing inherently wrong with it, I just wanted to provide a little background.

It's alright that you're being patient. The patient people tend to have long-term success. Consider the gradual bumping up; there's no race to find maximum dosing without side effects if you get benefits from a lower dose.

Thank you, this is very helpful.

 

[ahhamunster]

There are different ways you can approach dosing:

One would be to establish a higher goal dose that you're trying to reach (e.g. maximize weight loss rate). Another would be to target dosage minimization (e.g. as long as you're still losing some weight stick to that dose).

The other (and probably most common method) of allowing perceived food noise and hunger signaling to guide you seems very intuitive, but comes with the risk that you're likely chasing after an unrealistic goal, similar to dosing a pain med until the pain is completely gone.

This is helpful. I will continue to titrate as needed. But will keep in mind your last statement, about the unrealistic ever moving goal. That makes perfect sense and kind of worries me ha!

 

[yrrdead]

Another thing that often gets missed is our goals aren't quite aligned with the trials. Our goals are weight loss . So let that guide you. If you are losing 1-2lbs a week then I wouldn't touch anything. Stall for a week or two? Well might be time to titrate up, might also be a good time to reassess your maintenance calories as your TDEE goes down as your weight goes down.

I also know personally its fun to see the scale go down and there is definitely some type of dopamine hit from that. Because I want to bump my dose and intellectually I know I don't "need" to.

 

[Calm Logic]

YES. The first three nights after I pin, I sleep but feel do not feel rested whatsoever.

I would check your vitals again, especially heart rate, and consider taking tirz instead if the sides are a problem.

On the positive side, with reta:

Weekly Weight Loss Comparison: Tirzepatide vs. Retatrutide

Metric Tirzepatide (Zepbound) Retatrutide (Trial Data) Typical Weekly Loss 1.0 – 2.0 lbs 1.5 – 2.5 lbs First 6 Months ~15% of body weight ~17.5% of body weight Total Study Loss ~22.5% (at 72 weeks) ~28.7% (at 68 weeks) Hormone Targets 2 (GLP-1, GIP) 3 (GLP-1, GIP, Glucagon)

 

[Really? 26135]

The real question is are you happy with your current progress?

If your happy with your current progress then there’s no reason to up the dosage