这可能是一个愚蠢的问题。

[FartfulCodger]

The only thing I think about is that the longer we are at an unheathy weight, the longer that unhealthy weight’s related issues like inflammation are affecting our health in possibly an irreversible way.

My BP has dropped dramatically in the past 5 during over my 50-pound loss. Even without the weight loss, I'm glad that I'm getting to a healthy BP faster.

 

[sheilarae74]

I have stuck with only losing 1-2 lbs a week for the past year and a half. At 52, I am convinced this method has kept my skin from sagging worse than it has been.

 

[Devilseye]

I think that the window of opportunity is a very real thing. You do get used to the drugs and they do become less efficacious. Max out your weight loss while appetite control is high is as calid a strategy as any. Theres also evidence of the setpoint theory that your body will loose weight until it gets to its new “equilibrium”. In either case, the only thing that the take it slow approach can probably give you is more fat mass loss vs lean body mass if you train and eat properly.

Also regarding skin laxity i dont think there is any correlation. If your skin has stretched out beyond your elasticle capacity you will have loose skin. Period. Its genetic to some extent and depends on your fat gain %.

 

[Cypress]

I am working out almost every night, I don't want to be skinny fat. I just started klow to prevent the skin laxity (hopefully). Maybe I'll look like I'm 20 again (and maybe pigs will fly).

 

[Grogu]

I think that the window of opportunity is a very real thing. You do get used to the drugs and they do become less efficacious. Max out your weight loss while appetite control is high is as calid a strategy as any. Theres also evidence of the setpoint theory that your body will loose weight until it gets to its new “equilibrium”. In either case, the only thing that the take it slow approach can probably give you is more fat mass loss vs lean body mass if you train and eat properly.

Also regarding skin laxity i dont think there is any correlation. If your skin has stretched out beyond your elasticle capacity you will have loose skin. Period. Its genetic to some extent and depends on your fat gain %.

I would agree with all of this, the only thing I would add is that we don't know the role of using multiple glp-1s or other treatments after the window of opportunity to encourage more weight loss.

What is clear, at least for tirzepatide, is that weight loss plateaus at about 12-15 months and patients stay at the lower weight as long as treatment is continued and that there is no significant additional weight loss after the 12-15 months.

What we don't know is what happens after the window if the patient switches to reta or adds phentermine, phentermine/topiramate, or naltrexone/bupropion to tirzepatide in combination. Will that carry the patient to "goal". I'm not sure that there is any evidence or current clincial guidlines for what to do when folks don't reach their weightloss goal on their first glp-1.

 

[HereKittyKitty]

I think that the window of opportunity is a very real thing. You do get used to the drugs and they do become less efficacious. Max out your weight loss while appetite control is high is as calid a strategy as any. Theres also evidence of the setpoint theory that your body will loose weight until it gets to its new “equilibrium”. In either case, the only thing that the take it slow approach can probably give you is more fat mass loss vs lean body mass if you train and eat properly.

Also regarding skin laxity i dont think there is any correlation. If your skin has stretched out beyond your elasticle capacity you will have loose skin. Period. Its genetic to some extent and depends on your fat gain %.

And age. Laxity also depends on age.

 

[CariocaLeftSeoul]

And age. Laxity also depends on age.

I think age is a huge factor. My skin was never stretched out beyond capacity since I don't have stretch marks and didn't have lose skin after my pregnancies, even though my total weight at the end of those was considerably more than my total weight before starting GLP-1, and I did lose weight after my pregnancies. But that was also 11 years ago, and now my weight loss wasn't superfast, but my skin is loose and feels thin.

 

[spanky2026]

我担心那些需要减掉很多体重的人，会误以为缓慢而“更好”且“更少作弊”，从而放弃了治疗的全部益处，最终无法达到如果他们采取更积极的（如果他们能够耐受的）剂量递增方案本可以达到的减肥目标。

没错！在Reddit和Facebook之类的很多子版块里，低剂量缓慢疗法几乎成了一种狂热的推崇。虽然这种方法对某些人有效，但正如你所说，研究表明，如果你有很多东西要失去，高剂量反而能带来最佳效果，低剂量疗法没有任何优势。我的天哪，我真怕在某些群组里指出这一点会被喷得体无完肤。

 

[Grogu]

没错！在Reddit和Facebook之类的很多子版块里，低剂量缓慢疗法几乎成了一种狂热的推崇。虽然这种方法对某些人有效，但正如你所说，研究表明，如果你有很多东西要失去，高剂量反而能带来最佳效果，低剂量疗法没有任何优势。我的天哪，我真怕在某些群组里指出这一点会被喷得体无完肤。

对于我们这些爱看电视的人来说，每天都会被瑞贝尔·威尔逊（Rebel Wilson）的广告轰炸，她大肆宣扬微剂量疗法的种种好处。“微小改变，巨大效果”。 她不再是那个胖艾米了，她是微剂量疗法的代言人。

说实话，当我第一次了解Zepbound并在网上查阅资料时，我也觉得缓慢小剂量才是最好的。后来我看了临床试验和一些科学文献，然后才意识到，嗯，不对。这种方法并不适合大多数人。