我应该何时增加利他林的剂量？
- Thread starter donzilla
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一周的时间相对较短，不足以评估你的反应。但试验是从 2 毫克开始的，所以如果你觉得副作用可以忍受，甚至目前还没有副作用，我认为你可以增加到 2 毫克。记住，药物需要 4 周才能达到治疗浓度，所以如果你增加到 2 毫克，你应该保持一个月。我最初两周每周服用两次，每次 1 毫克，之后增加到每周一次，每次 2 毫克。但现在回想起来，我当时应该直接从每次 2 毫克开始服用，但这只是我个人的情况。一切都取决于你的个人反应。
达到特定剂量的稳态大约需要 4 周时间。稳态并不等同于治疗剂量。
我之前服用 Tirz，后来换成了 Reta，目的是为了增强 GCGR 信号传导。据估计，要可靠地激活该信号传导，治疗剂量约为每周 6-8 毫克，这意味着稳态时的平均暴露量为 7.5-10 毫克，每周单次给药的谷值约为 5 毫克，峰值约为 14.5 毫克。
由于我之前一直在服用 Tirz，所以我迅速地增加了 Reta 的剂量，并多次小剂量服用，同时密切观察副作用。我在第 16 天达到了累积剂量 7.5 毫克，并从第 18 天起一直保持在 7.5 毫克以上。没有出现任何不良副作用，对我来说，这是一个轻松平稳的过渡，现在已经 36 天了。
我之前服用 Tirz，后来换成了 Reta，目的是为了增强 GCGR 信号传导。据估计，要可靠地激活该信号传导，治疗剂量约为每周 6-8 毫克，这意味着稳态时的平均暴露量为 7.5-10 毫克，每周单次给药的谷值约为 5 毫克，峰值约为 14.5 毫克。
由于我之前一直在服用 Tirz，所以我迅速地增加了 Reta 的剂量，并多次小剂量服用，同时密切观察副作用。我在第 16 天达到了累积剂量 7.5 毫克，并从第 18 天起一直保持在 7.5 毫克以上。没有出现任何不良副作用，对我来说，这是一个轻松平稳的过渡，现在已经 36 天了。
I think if someone brand new to GLPs and just starting with Reta, like it sounds the OP is, therapeutic levels and steady state are pretty close together. I felt my first 1 mg dose later the same day. Each week just reinforced the effects I felt that first day, so going by "feels" it felt therapeutic to me from the start. If someone is concerned about moving from 1 mg to 2 mg after a week, I don't think it's an issue but everyone is different.woundcarping said:
Depends on personal tolerance. I started at 2 and upped .5 every 5 days. I am pinning 4 next, possibly 4.5 because my sides are mild and I am still eating a good bit just not snacking and gorging myself out...donzilla said:
I would have no problem titrating immediately to 2mg and stay there for a few weeks to see how you are handling it.donzilla said:
It takes a full 28 days for the GLP to reach full effect or the saturation level for that dose. It might have some effect before then, but doesn't reach full effect whether that's 2mg or 4 mg or whatever. I didn't mean zero effect.donzilla said:
The best way to visualize how your dosage reaches saturation, and what levels you're at and when, is with a plotter. You can plug in your dosage, or project your dosage, and see what it looks like. https://glp1plotter.com/
FWIW, I have zero sides on Reta on 4 mg every 84 hours.
If it's working at 1 mg / week for you, I'd stay there for the full four weeks before you consider titrating up.
It's likely perfectly fine for you to titrate next week since 2 mg is the Phase III starting dose and you've tolerated it well.
Nb. though that this is a marathon, not a sprint. GLPs take time to build in the body and reach full therapeutic levels. If nothing else, it'll save you some money since you can stretch your supply further on the lower dose.
If it's working at 1 mg / week for you, I'd stay there for the full four weeks before you consider titrating up.
It's likely perfectly fine for you to titrate next week since 2 mg is the Phase III starting dose and you've tolerated it well.
Nb. though that this is a marathon, not a sprint. GLPs take time to build in the body and reach full therapeutic levels. If nothing else, it'll save you some money since you can stretch your supply further on the lower dose.
I think it depends a bit on where you are and what you want from it . If you are severely overweight in some ways it makes more sense to go slowly, losing lots of weight fast carries extra risks of gallstones, fainting etc.
The fact is if you up doses faster than every 4 weeks you increase your chances of getting bad side effects, and as the drug has such a long half life they can take a week or more to subside. The standard common side effects are nausea vomiting diarrhoea and constipation. The problem is vomiting for a week is a real problem that could land you in hospital on a drip if you are unlucky. The other thing to know is peak side effects are normally at about month 2 to 4 after starting at mid range doses as they are increasing. But everyone is different in terms of side effects.
You absolutely need to understand the pharmacodynamics of the drug before upping doses faster, and use glp plotter to see what different doses do to blood levels, and understand that it takes 4 weeks at a given dose to get to maximum levels in your blood which is why the recommendation is to only increase doses every 4 weeks.
The only semi safe way to increase doses faster is to use frequent small doses, every second or 3rd day, so that when you overshoot your tolerance and get side effects that are unpleasant, it wont take a whole week for levels to drop to where they were before you had that dose. Even doing this and checking out glp plotter, you are much more likely to get unpleasant side effects if you try to increase doses any faster than the standard.
At only 1mg having another 1mg dose 3 to 4 days after the last dose is a lower risk way to do it than a 2mg dose a week later. And then you see what happens in terms of side effects vs hunger suppression. And you can always work out a weekly dose once you are at a dose that suits you and swap to that, which is simply the sum of the smaller doses over a week.
The fact is if you up doses faster than every 4 weeks you increase your chances of getting bad side effects, and as the drug has such a long half life they can take a week or more to subside. The standard common side effects are nausea vomiting diarrhoea and constipation. The problem is vomiting for a week is a real problem that could land you in hospital on a drip if you are unlucky. The other thing to know is peak side effects are normally at about month 2 to 4 after starting at mid range doses as they are increasing. But everyone is different in terms of side effects.
You absolutely need to understand the pharmacodynamics of the drug before upping doses faster, and use glp plotter to see what different doses do to blood levels, and understand that it takes 4 weeks at a given dose to get to maximum levels in your blood which is why the recommendation is to only increase doses every 4 weeks.
The only semi safe way to increase doses faster is to use frequent small doses, every second or 3rd day, so that when you overshoot your tolerance and get side effects that are unpleasant, it wont take a whole week for levels to drop to where they were before you had that dose. Even doing this and checking out glp plotter, you are much more likely to get unpleasant side effects if you try to increase doses any faster than the standard.
At only 1mg having another 1mg dose 3 to 4 days after the last dose is a lower risk way to do it than a 2mg dose a week later. And then you see what happens in terms of side effects vs hunger suppression. And you can always work out a weekly dose once you are at a dose that suits you and swap to that, which is simply the sum of the smaller doses over a week.
What if you’re using pre filled pens? I’ve heard the potency wears off as the solution is already mixed. So people tend to start higher? But if your mixing with bac water and reconstituting it yourself, you should start lower?
It sounds like you need to do some more reading before using GLP peptides. The dose is the dose, and how it is delivered is irrelevant, it matters a lot that you understand the correct dose to take , how to mix the peptide with bac water and how to make sure you end up using the dose you intended to use. Getting this wrong is super easy, the biggest risk of diy GLP's is dosing errors. There are no guard rails to stop you hurting yourself. Do lots of reading and watch tutorials.techiemichael said:
Once mixed any peptide solution is going to degrade a bit, but generally if refrigerated this effect is insignificant , at most 1-2% or so over a few months ( for most of them ). Peptides prepared by pharmaceutical companies and sold in prefilled pens are very carefully formulated to degrade very slowly and be fine to use for years, though most also need to be kept in the fridge to minimise degradation. Self mixed peptides , in vials mixed with bac water are not as precisely formulated and should ideally be used in a month and kept in the fridge, though I am happy to use them for up to 3 months as a few percent degradation that might or might not happen is totally insignificant in terms of effect on dose.
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