我们从中国进口的tirz peps

[joseblo]

My EL zepbound makes my ears ring (very loudly) the second and third days. I love your saying your side effects being the same is reassuring you’re getting the same med.

I’m looking for the ancillary effects like antiinflammatory etc so that really resonates. Imma refrain from wondering which source it was, but I imagine you went back to them.

You might check your HR and blood pressure during the week as well, if you have a cuff. Tinnitus can be related to higher blood pressure.

 

[Labcat]

You might check your HR and blood pressure during the week as well, if you have a cuff. Tinnitus can be related to higher blood pressure.

That’s a good point! My BP and HR seems the usual weirdness it is. But I’ll check it again now. Data! I did just take a bunch of caffeine for my migriane though.

Too bad I can’t check pressure in my ears.

 

[Sasquatch]

My EL zepbound makes my ears ring (very loudly) the second and third days. I love your saying your side effects being the same is reassuring you’re getting the same med.

I’m looking for the ancillary effects like antiinflammatory etc so that really resonates. Imma refrain from wondering which source it was, but I imagine you went back to them.

I'm sitting here with my ears screaming on day 2. May I ask your tirz.dosage? I'm 3 weeks into 12.5mg.

 

[Labcat]

I'm sitting here with my ears screaming on day 2. May I ask your tirz.dosage? I'm 3 weeks into 12.5mg.

DMing u

 

[john_askins]

I’m glad you asked this because this is one of my main concerns with my push to switch to grey. I’m trying to parse through all of the vendors to decide which is the best product and which is the most trustworthy and I’d be really sad if something I ended up with gave all my side effects back.

 

[Gr33dyOctopus]

I’m glad you asked this because this is one of my main concerns with my push to switch to grey. I’m trying to parse through all of the vendors to decide which is the best product and which is the most trustworthy and I’d be really sad if something I ended up with gave all my side effects back.

Pfttttt, I dont know that many/any of them are "trustworty". Its the wild west here and folks hide behind anonymity.

 

[Labcat]

Truer words…

 

[MsGizmo]

Feel the same as the tirz from compounding pharmacy? I imagine the answer is yes, I've ordered the transfer syringes, the empty Vials, the filters and just about to order a bunch of dry tirz. So curious to see how it feels compared to the bottles I paid 200 or more for 60 or 72mg.

Well, I went directly from pharmacy semaglutide to grey market semaglutide and there was zero difference. There is no reason to expect the other GLP1s are any different.

 

[joseblo]

Pfttttt, I dont know that many/any of them are "trustworty". Its the wild west here and folks hide behind anonymity.

I’ve seen a number of posts on different forums hinting that even the same API could somehow be different, and it’s never been clear to me what is meant chemically. Can someone explain please how identity can confuse different but closely related molecules on 3P testing? I’d like if someone could share an explanation in chemistry, using the basics like “electrons” or “orbitals” or “conformation”, with a specific example which could be theoretic… rather than handwavy.t

Truer words…

In general I don't think this is an issue with the better labs. Certainly, Janoshik can identify peptides from blind samples with HPLC-MS. Otherwise, they wouldn't be able to tell you what it really is (eg MOTS-C vs Tirz) in a screwup. What they can't really do is tell you purity of different components, if there are multiple components, because all of the peak overlap each other, but they can still give weight of each one, if each is known. I'm not an expert in these particular measurements, but I've used HPLC.

The other problem is reconstitution. It's possible to get peptides that won't dissolve properly (eg at a particular pH) and that can lead to ZERO peptide results. This happened recently with Survo that appeared to be free base (or incorrect salt) which would dissolve at lower pH.

Of course NN and EL apparently ship freebase (non salt) in their pens with whatever bacteriostatic/preservative necessary to get months of room temp storage. They don't need to do any lyophilization.

Now, if you're talking about things bigger than peptides (proteins), then folding becomes an issue for "biologics" and chemically they can be the same, but one folding could be effective while the other is not. Stereo isomers (or racemic mixtures) are another issue for small molecules, but again apparently not an issue in the solid phase synthesis used for the common peptides.

Again, I'm not an expert in these particular measurements, but the explanations I've read by others make sense from a chemical manfuacturing, purification, storage, and testing perspective.

 

[Labcat]

一般来说，我认为这对于比较好的实验室来说不是问题。Janoshik 实验室当然可以用 HPLC-MS 从盲样中鉴定肽。否则，如果出现错误，他们就无法告诉你样品到底是什么（例如 MOTS-C 还是 Tirz）。他们无法真正做到的是告诉你不同成分的纯度（如果存在多种成分），因为所有峰都会相互重叠，但如果已知每种成分的含量，他们仍然可以给出每种成分的重量。我不是这些特定测量方面的专家，但我确实使用过 HPLC。

另一个问题是复溶。有些肽可能无法正常溶解（例如在特定的 pH 值下），这会导致肽的检测结果为零。最近 Survo 就出现了这种情况，它似乎是游离碱（或错误的盐），在较低的 pH 值下才能溶解。当然，

NN 和 EL 显然在他们的笔中装的是游离碱（非盐），并添加了必要的抑菌剂/防腐剂，以确保其在室温下可以保存数月。它们不需要进行冻干。

但是，如果讨论的是比肽更大的分子（蛋白质），那么折叠就成了“生物制剂”的一个问题。从化学角度来看，它们可能相同，但一种折叠方式可能有效，而另一种则无效。立体异构体（或外消旋混合物）是小分子面临的另一个问题，但显然在用于合成常见肽的固相合成中并非如此。

再次声明，我并非这些特定测量方面的专家，但我读到的其他人的解释从化学制造、纯化、储存和测试的角度来看是合理的。

看到你写的内容我太高兴了，因为我读过很多类似的文章，也自欺欺人地觉得好像有点道理，但我仍然感觉自己好像在自欺欺人，以为自己真的理解了，哈哈。

我之前都没听说过舒沃（Survo）不溶解！不过应该没人会注射吧？虽然如果我知道它是纯的，我可能还是会试试……假设少量舒沃会溶解，然后随着注射的进行，它会溶解更多，重新达到平衡，有点像某些长效注射剂的原理。有人成功用过舒沃吗？（或者有人胆子大到敢尝试吗？）