When will we get grey eloralintide

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Rockybalboa said:
The little i have read so far is that it only seems to supresse apetite, just as Tirza.

If thats how it works i think Reta still will be the best GLP product.

But i have not read enough about yet to be some kind of expert.

If there is anyonelse who have a more detailed picture of it. Please share it here 😊
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I think Reta is also the most effective one because it is the most popular
 
geoguy78 said:
Tirz-Elora may end up being EL's competitor to Cagri-Sema. The combo of tirzepatide and eloralintide would be a triple agonist, very curious how it would stack up against retatrutide in trials.
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As a triple agonist, Tirz-Elora (tielpolin + elolarinpeptide) may become Eli Lilly's competitor to Cagri-Sema.

Compared with retalutide:

1. Different mechanisms: The former targets GLP-1, GIP and amylin receptors, focusing on enhancing appetite suppression; The latter, with the additional effect of glucagon receptors, may be more conducive to fat burning.

2. Effect to be determined: Both may have a strong effect on weight loss, but the early data of retalutide is more prominent.
 
Cassie MKM said:
As a triple agonist, Tirz-Elora (tielpolin + elolarinpeptide) may become Eli Lilly's competitor to Cagri-Sema.

Compared with retalutide:

1. Different mechanisms: The former targets GLP-1, GIP and amylin receptors, focusing on enhancing appetite suppression; The latter, with the additional effect of glucagon receptors, may be more conducive to fat burning.

2. Effect to be determined: Both may have a strong effect on weight loss, but the early data of retalutide is more prominent.
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as it stands reta seems to be a bit more effective than tirz, and once elora and reta are out, there's no apparent reason they couldn't combine them

tirz and elora also seem to have the same primary effect (reducing food noise/appetite) whereas reta is considered the weakest at that despite apparently being the most effective overall for weight loss

in my opinion, this reasons out to reta+elora being the most effective combination therapy in the next few years, as the elora complements reta perfectly in fixing its only apparent weakness while both being approximately the best in their class
 
gulangaloid said:
as it stands reta seems to be a bit more effective than tirz, and once elora and reta are out, there's no apparent reason they couldn't combine them

tirz and elora also seem to have the same primary effect (reducing food noise/appetite) whereas reta is considered the weakest at that despite apparently being the most effective overall for weight loss

in my opinion, this reasons out to reta+elora being the most effective combination therapy in the next few years, as the elora complements reta perfectly in fixing its only apparent weakness while both being approximately the best in their class
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wouldn't reta + cagri be the same ? What receptors does elora hit ?
 
juGGaKNot said:
wouldn't reta + cagri be the same ? What receptors does elora hit ?
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similar, yes, but eloralintide seems to be more effective. they're both amylin receptor agonists.

reta and elora are also made by the same company unlike cagri, so it's likely it can/will be prescribed as an official combination therapy in the next several years. obviously less relevant for gray market using experimenters, but more relevant from a public health perspective.
 
juGGaKNot said:
wouldn't reta + cagri be the same ? What receptors does elora hit ?
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Elora is an amylin receptor agonist. Similar to cagrilintide. Although cagri is technically a dual receptor agonist as well because it works on both the amylin and calcitonin receptor. I'm not sure if elora works anything other than amylin. So tirz+elora would be a GLP-GIP-Amylin receptor agonist, and reta+elora would be a GLP-GIP-Glucagon-Amylin agonist
 
geoguy78 said:
Elora is an amylin receptor agonist. Similar to cagrilintide. Although cagri is technically a dual receptor agonist as well because it works on both the amylin and calcitonin receptor. I'm not sure if elora works anything other than amylin. So tirz+elora would be a GLP-GIP-Amylin receptor agonist, and reta+elora would be a GLP-GIP-Glucagon-Amylin agonist
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So, after stacking Tirz, Survo, and Elora, The stack will be nearly identical to Reta and Elora.

Check me here... is this right?
 
juGGaKNot said:
But reta + cagri still better?
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Prolly gonna be one of those fun constant comparisons that depend which team your on. I have 6 years of T. So for me, it's the T stack FTW
 
As long as this doesn't have strict pH requirements and potential dangers, I'll take this over cagri.
 
https://www.sciencedirect.com/science/article/pii/S2212877825001784

In a rat study, they found that eloralintide led to significantly less lean muscle loss than cagrilintide. See Figure 5D.

I wouldn't mind seeing a pdf of the new Lancet Phase II study.
 
So I've been reading up and apparently eloralintide was specifically engineered to have minimal calcitonin receptor agonism, so it's not just an EL copycat of cagrilintide, it's a pure amylin receptor agonist.
 
juGGaKNot said:
But reta + cagri still better?
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Elora gives substantial weight loss on its own, much better than cagri by itself. Maybe if you had limited weight to lose, or are in maintenance cagri would be just fine. For maximum effect I think Elora and Reta couldn't be beat.
 
IshimaruKenta said:
As long as this doesn't have strict pH requirements and potential dangers, I'll take this over cagri.
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Definitely waiting for the trial data on this. Likely will still have some pH requirements due to it being an amylin precursor
 
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