What is MOTS-c like?
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redbullwings
GLP-1 Apprentice
good luck, I hope you find better results. do keep us updated xHyperion said:
Jellybelly54
GLP-1 Enthusiast
The biggest thing I’ve noticed on MOTs is allergic reactions and intense itching at the injection site when doing anything over 1 mg. If I SQ it the redness and itching is unbearable. If I go IM the muscle swells significantly . Never had a systemic reaction but I’m always ready just in case. If I stay at 1 mg and IM then I’m usually fine. I would NOT dose at 5-10mg until I knew I did t react to it, otherwise you could end up with an anaphylactic rxn. It’s a known and well documented thing with MOTs so be careful.
miss-sanne
GLP-1 Enthusiast
No, I take 5 mg mon-wed-fri, sometimes sunday. Yes you can add it.Phatmax said:
miss-sanne
GLP-1 Enthusiast
Mots is a peptide that the body makes itself.Jellybelly54 said:
What do you mean by 'well-documented' ?
I think its very rare.
There are no peer reviewed reports on that and no case reports anywhere ?
Yes you can get vaso vagal reactions and get really unwell, and it does give local inflammation/local allergic reactions.
But you can get anaphylaxis of everything in theory, but that is all things you inject. (or eat etc)
I am more concerned about all the other stuff in the vial, the pH, the endotoxins, why it's important to filter, or wrong dosing etc.
Jellybelly54
GLP-1 Enthusiast
I’m just referring to you tube vids I’ve seen by various dudes talking about the anaphylaxis and allergic reactions . All I’m saying is it is a thing to monitor and be aware of. I’m like you, I filter everything with a 13mm PES 0.2um filter just to help remove bacterial contaminants and trash. I’m not to risk adverse though so LPs and other bogeymen don’t scare me much or I wouldn’t be swimming with the grays! It wasn’t long ago all the Fu Med gurus were literally selling books called Eat More Dirt and telling everyone to stop using bath soap, consider fecal transplants whole bunch of other shit like that! Now it’s “avoid all EMFs, sleep in a Faraday cage, take hormones, put red light on your privates, bath in peptides and use a squatty potty! “ There’s a happy medium somewhere . Rant…!!miss-sanne said:
Calm Logic
GLP-1 Specialist
miss-sanne said:
At least with IM administration, there are cases of anaphylactic reactions to MOTS-c, but no fatalities so far that I know of. I know someone personally (tongue and throat swelling after 5 mg by IM, using a new vial/vendor with no such issues before). Also mentioned in passing at Meso:
quoted said:
View: https://www.youtube.com/watch?v=XcIHs6jY7CU
A couple cases at Reddit, in a single thread:
quoted said:
More generally but publicly, two women almost died soon after being injected with peptides (which ones, I don't know) at a peptide festival of sorts:
Epi Pen resources?
Has anyone managed to buy some Epi Pens as a hedge against potential anaphylaxis? If so, what was your process? Is there a go-to telehealth that can issue a scrip?
glp1forum.com
We still don't know what those women took. That was related to Tirz from HYB testing a zero by Janoshik, and the vendor replaced all the suspect kits. I've never heard of any confirmation other than they got "sick".I'm going to titrate up from 1 mg when I start Mots-C.
Jellybelly54
GLP-1 Enthusiast
There are so many other peps/small molecules that do similar work as MOTS. I could think of multiple safer peptides; humanin, 5A 1MQ, SS31, red light therapy… What am I missing? I’m sure there are more?
waxtutor
Recently Joined 🚫No Source Discussion🚫
Mots c does something completely different than everything else you are taking, Mots c effects the mitochondria, you can cycle on and off ss31 nad+ and mots c at pretty much anytime you will want to do your own research on these compounds. The dosing is usually split dose between days m/w/f because of the half life of mots c.Phatmax said:
waxtutor
Recently Joined 🚫No Source Discussion🚫
long story short don't put these sub q peptides into your vein. Diligently do your research. And know at least a little bit what you are doing before injecting anything into your body.Calm Logic said:
MrBMG
GLP-1 学徒
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I ran mots 5mg 3x/wk for 4 weeks. Was weird. I couldn’t tell if it was working or not until week 3 I noticed a clean energy. Wasn’t a pump or stim feeling, I could just go and go. With it taking that long, I was going to run it for 6 weeks but cut it short. End of February I’m going to run the whole mitochondrial protocol (ss31/mots/nad) as I’m 45 and have some miles on this body.
I also supplement l-citrulline (6-8g) daily before workouts, and l-carnitine (3g) daily. On top of a bunch of other stuff. Idk how it compares to those.. but I will say it’s a nice jump in constant energy, or is for me. Everybody has had different responses to lower and higher doses I’ve seen, but that’s what seems to have worked for me.
I also supplement l-citrulline (6-8g) daily before workouts, and l-carnitine (3g) daily. On top of a bunch of other stuff. Idk how it compares to those.. but I will say it’s a nice jump in constant energy, or is for me. Everybody has had different responses to lower and higher doses I’ve seen, but that’s what seems to have worked for me.
miss-sanne
GLP-1 Enthusiast
Thanks for replies.
I think, we have to make the difference between 'cases' and 'increased risk of serious adverse reactions'.
We have no idea what was in their vials, because it's not pharma.
But all medicine can give anafylaxis in rare cases, also Tirz , Reta, Sema.
It's on the list of rare side effects.
But of course be careful always.
I always do a small amount of any new kit vial before the full dose, just to see.
I think, we have to make the difference between 'cases' and 'increased risk of serious adverse reactions'.
We have no idea what was in their vials, because it's not pharma.
But all medicine can give anafylaxis in rare cases, also Tirz , Reta, Sema.
It's on the list of rare side effects.
But of course be careful always.
I always do a small amount of any new kit vial before the full dose, just to see.
miss-sanne
GLP-1 Enthusiast
Amen to that.waxtutor said:
miss-sanne
GLP-1 Enthusiast
Actually, I often forget to do the mots. ;-) So maybe it's two times per week.
Do you all cycle off at some point ? I see different opinions on that.
Do you all cycle off at some point ? I see different opinions on that.
lessthanhalf
GLP-1 Specialist
Putting any of these peptides directly into a vein is probably a very bad idea, maybe not quite as dangerous as street heroin. But a very tiny number of bacteria are required to start a very serious systemic infection if you inject them intravenously and usually if subcutaneous your immune system is going to cope. Peptides from china are nowhere near the standard of sterility required to be safe for IV use. Doing this with Mots c sounds like an amazingly bad idea.
Mots c would seem to be a much more likely than average peptide to cause anaphylaxis. Most people on this forum seem to get localised allergic reactions to it. And it is not a big step up in immune reaction to anaphylaxis. It is a peptide made inside your body , but made by a weird ancient bacteria that got stuck in our cells, and mitochondrial proteins are immunogenic. The levels of mots c present normally in your blood are very small, much much lower than levels generated by a dose of 5mg, which is possibly why it still has effects despite the likely low half life ( not ever actually tested in humans ), which is the case for a lot of peptides, except the GLP's as they have long fat molecules stuck onto them to stop them being rapidly degraded like normal GLP-1.
Mots c would seem to be a much more likely than average peptide to cause anaphylaxis. Most people on this forum seem to get localised allergic reactions to it. And it is not a big step up in immune reaction to anaphylaxis. It is a peptide made inside your body , but made by a weird ancient bacteria that got stuck in our cells, and mitochondrial proteins are immunogenic. The levels of mots c present normally in your blood are very small, much much lower than levels generated by a dose of 5mg, which is possibly why it still has effects despite the likely low half life ( not ever actually tested in humans ), which is the case for a lot of peptides, except the GLP's as they have long fat molecules stuck onto them to stop them being rapidly degraded like normal GLP-1.
Super Trips
GLP-1 Enthusiast
5mg a day 5 days a week for me for 4 weeks then switch ss-31 same dosages
Mr.Tired
GLP-1 Apprentice
For anyone who has done one or more cycles of MOTS, do the benefits last after you stop the cycle?
My hope is that after repairing the mitochondria they stay repaired (assuming I take care of myself with appropriate diet and exercise)
My hope is that after repairing the mitochondria they stay repaired (assuming I take care of myself with appropriate diet and exercise)
Mystici 30390
Recently Joined 🚫No Source Discussion🚫
I am also doing the protocol by the end of February, wanna keep in touch to see what improves? I'm doing it for mainly some sort of insulin resistance.MrBMG said:
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