What dose of reta are you at?

[Muffyflowers]

What exactly is "skin sensitivity"... pain, itch, burning or?

Are the symptoms localized or wide spread?

Do they present as a rash or raised surface?

I got it when I bumped from .5 to .75 it went away but a flash of like a burning tingle.

 

[Ultra_Unlimited]

Just got up to 8 mg this week, and skin sensitivity was confirmed: a slight tingling sensation, hard to describe, not painful at all, but I can notice the texture of many items of clothing when I otherwise would not have been able to.

Though that said, it's highly manageable for me at this time.

As for dosage escalation, I started relatively slow and low, but once I got to 3-4 mg, I made the executive decision for my next move to be more substantial, to 8 mg instead of a slower escalation, because I really haven't dealt with negative sides.

Positives have been there but much more in terms of body comp vs pure weight loss. I presume, having lost a lot with semaglutide a couple years back, the higher dosage is needed to really move the needle.

 

[RetCurious]

Is that to someone specifically or in general?

Can be localized or not, commonly described as some variety of a sunburn but no visual signs of the sensitive area.

In general, thank you.

 

[390120]

What exactly is "skin sensitivity"... pain, itch, burning or?

Are the symptoms localized or wide spread?

Do they present as a rash or raised surface?

I tried to explain it today but I found it a bit difficult, there’s no rash or raised surface for me but it feels sensitive when rubbing against clothing, kind of like a prickly feeling sometimes, like almost pins and needles but not

 

[Myfathersbastard]

3mg week 5 for me

Twins!

 

[Myfathersbastard]

Currently on week 5 and started taking 3mg today, on a 6 day schedule. Down 13 lbs so far.

 

[BNLFL]

Just got up to 8 mg this week, and skin sensitivity was confirmed: a slight tingling sensation, hard to describe, not painful at all, but I can notice the texture of many items of clothing when I otherwise would not have been able to.

Though that said, it's highly manageable for me at this time.

As for dosage escalation, I started relatively slow and low, but once I got to 3-4 mg, I made the executive decision for my next move to be more substantial, to 8 mg instead of a slower escalation, because I really haven't dealt with negative sides.

Positives have been there but much more in terms of body comp vs pure weight loss. I presume, having lost a lot with semaglutide a couple years back, the higher dosage is needed to really move the needle.

I've been on 4mg for two weeks, and two more to go on 4mg. I'm going to decide if we want to jump to 8mg or stay at 4mg for a while after my results in about a week and a half. I've been dropping 3lbs a week. Started at 2mg. Looking forward to your results.

 

[V6R3W]

What exactly is "skin sensitivity"... pain, itch, burning or?

Are the symptoms localized or wide spread?

Do they present as a rash or raised surface?

My skin sensitivity feels very much like a sunburn. Clothing is a little uncomfortable when it rubs against whatever area is sensitive.

Mine has never reached the "painful" threshold, just noticeable and mildly uncomfortable at worst.

 

[ntotheth]

Hello from the UK.

I've just started today at 2 mg. So wish me luck.

I've previously been on Mounjaro and reached 15mg, but the last dose was over a month ago.

It will be interesting to see how it feels.

I sourced a single vial from the UK supplier. (Obviously, I paid too much!), but depending on how it goes I'm looking at buying kits from China, like everybody else. I just want to check i get on ok with Reta, as may revert back to Tirz so didnt want to make a big order.

 

[onewalker]

I just upped my dose to 2 mg this morning after two weeks of 1 mg. For the record, I've been on Ozempic since February 2024 and took my last Ozempic jab last week.

 

[Peptidesearch]

Why do people do 'lowest effective dose'? Why not just try to hit the 12mg max asap if that is what the trials show work? Is it to minimize side effects or to save money? Seems the cost savings are minimal with a lower dose.

I prefer staying at the lowest effective dose until it loses effectiveness, only then would I move up.

 

[ntotheth]

Hello from the UK.

I've just started today at 2 mg. So wish me luck.

I've previously been on Mounjaro and reached 15mg, but the last dose was over a month ago.

It will be interesting to see how it feels.

I sourced a single vial from the UK supplier. (Obviously, I paid too much!), but depending on how it goes I'm looking at buying kits from China, like everybody else. I just want to check i get on ok with Reta, as may revert back to Tirz so didnt want to make a big order.

must admit, not noticing any effect from yesterday's 2mg of reta....

 

[390120]

must admit, not noticing any effect from yesterday's 2mg of reta....

I personally didn’t feel anything until I hit 4mg

 

[lessthanhalf]

This thread would be a lot more useful if people posted their start weight , goal weight and current weight . Interpreting what doses do what in different people has a lot to do with how much weight you are trying to lose and how much you have already lost.

I was already on 15mg of tirzepatide and trying to maintain a 54% weight loss. I saw a study showing 9% weight loss from only 1mg of reta over a year, which I thought was pretty amazing, none of the other GLP's are anywhere near that effective at really low doses, so I started adding reta to tirzepatide, currently on 5mg.

I think this result helps to explain the very wide range of doses of reta people are using.

 

[Nerker]

Update: Just finished week 6 of 2mg 1x weekly.

5'9", 52yo Male

I started at 208lb and am at 188.

20lb loss in 6 weeks.

No need to titrate up. Food noise (I ate ice cream, cashews and low fat mozz sticks at will) is 0% with these actors.

A note: for the last 5 years in January, I've locked into Whole eating with one cheat day and lost the same 20lb by April/May. Then I'd slowly fatigue from locking in and gain back.

I am accustomed and thrive in the eating right environment. It's nice to be here. No guilt.

I didn't think I had food noise but the thought of ice cream is non existent, feels "heavy" and "not worth it" when I think of it. No urge for cheat day or reward.

I will likely titrate down to microdose research after week 8, as my goal was to hit 175lb and I'll be close to that by week 8.

 

[Nerker]

must admit, not noticing any effect from yesterday's 2mg of reta....

I think on day 2 after first dose (2mg) I was at work and realized, "I really don't need to eat at all." And there was not a thought of my snacks during the the routine times I usually grazed. Miraculous shift in perspective.

 

[BNLFL]

My 3rd blast of 4mg Friday has really done a number on my appetite. I need find something different than beer, which I love. I've already knocked out about 80% of my old consumption. Went out for lunch around the corner, and was full at 2 wings and 3 beers. I'm supposed to make salmon and a salad, but no desire right now. I drink to much water I think, that also makes me full. Any opinions on the water deal?

 

[headward]

Because once you’re at the max you’ve been painted into a corner when tolerance kicks in. If you’re at a lower dose you can increase. If you’re at max dose you can either start stacking or exceed max, but that’s about it. So prob best not to rush to an unnecessarily high dose.

Thanks. I'm going to go down to maybe 2mg or so and intermittent water fast more, which is a lot easier with reta than without it. As is sticking to a meal plan/diet.

 

[lessthanhalf]

Because once you’re at the max you’ve been painted into a corner when tolerance kicks in. If you’re at a lower dose you can increase. If you’re at max dose you can either start stacking or exceed max, but that’s about it. So prob best not to rush to an unnecessarily high dose.

Tolerance to GLP medications is not really something that actually happens.

What people think is tolerance is usually the effect of weight loss, after a while of being on a dose of GLP you have lost weight , as you lose weight hunger goes up and metabolic rate goes down, so you stop losing weight and are a bit more hungry. But if weight is stable at that new point and not increasing, that is the drug doing its job, it has just done as much as it can in you at that dose.

If tolerance was real, and all the scientific studies say it is not , then people on these drugs for years would start gaining weight and every study says weight goes down for about a year then stabilises at that new lower weight and stays there for years ( I think 3-4 years is the longest follow up so far ). Assuming you continue on that dose.

Nearly everyone on these medications will get to a point where weight loss stops, hopefully this happens at a weight you are happy with, and at a dose that does not cause too many side effects, but how slow or fast the doses are increased , are not going to change where that point will be, that has more to do with genetics , lifestyle , exercise and diet, and the dose of reta you are on at the end. And to keep the weight off, that is the dose you are likely to need to stay on , assuming you are no longer losing weight at that point.

Whether staying on low doses as much as possible is a good idea , I think , depends on what you want from them. If you are younger and 10 kilos overweight good idea, average weight loss from 1mg of reta was nearly 9%.

If you have a BMI of over 35, and especially if you are older or have obesity related medical problems - metabolic syndrome , hypertension, heart disease, diabetes, high cholesterol etc. then I do not agree with the low dose approach. If you are losing weight at a rapid weight on a low dose, great there is no need to push the dose, or if side effects are a problem, but if you have a lot of weight to lose or weight loss slows or stops then increasing to the standard maximum dose of 12mg for reta is what you should be aiming for. It has been proven that higher doses are more effective than lower doses for preventing diabetes and heart disease, not for reta yet, but for semaglutide and tirzepatide, and though not proven yet it is very likely that this will also apply to reta. And obviously higher doses are more effective at causing weight loss, most recent longest term studies on reta show an average of 29% at 12mg which is amazing.

 

[ntotheth]

Hello from the UK.

I've just started today at 2 mg. So wish me luck.

I've previously been on Mounjaro and reached 15mg, but the last dose was over a month ago.

It will be interesting to see how it feels.

I sourced a single vial from the UK supplier. (Obviously, I paid too much!), but depending on how it goes I'm looking at buying kits from China, like everybody else. I just want to check i get on ok with Reta, as may revert back to Tirz so didnt want to make a big order.

2 mg, having no effect, so pinned another 2 mg after 3 days. I was on 12.5 mg of Mounjaro, so that's probably something to do with it. I still don't feel any effect now, however.

Anyway, I'll wait until next week, see how I feel.

Any advice from anybody coming from large doses of tirzepatide would be helpful.

I don't really want to go to 6 or 8 mg in week 1.