What a difference two years makes….. Meniscus/Osteoarthritis

[jw717us]

I’ve shared my Selank impact in another post and wanted to share the other part of my knew found appreciation for peptides.

Years ago I took martial arts with my young child rather than sit for hours every week doing nothing. We made blackbelt (strip-mall TKD style but then had some military guys join as the school started teaching BJJ. The classes became a little more cut-throat and in my 40s I was less than happy with some 26 years old infantry guys deciding to go for the knees and easy drops. My knees didn’t appreciate it and neither did I.

It eventually led to meniscus surgery to repair the damage. I trusted the surgeon and he worked wonders on a shredded rotator cuff years before. This time he didn’t warn me that osteoarthritis was a likely outcome and great accelerated. Years later that knee has started to sound like a bowl of rice krispees when I climb stairs. I’ve seen 2 more doctors and all of them question why that surgery was proposed. They also had no other path forward other than injections for a couple years followed by a knee replacement that will last approx 10 years. I only get two of those. I needed to stretch that roadmap out…

After Tirz for weightloss opened my eyes to peptides I started researching support for it. I paid through the nose and got telehealth subscription Rx’s for NAD+ and Semorelin. Those both made a huge difference in my GLP kickstarted weight loss journey to those of my wife and two other friends who started at the same time. The three of them are all down 20%ish in weight but have loss fat/muscle evently. Between those two peptides and working out I’ve managed to lose fat while gaining an equal % of muscle. Effectively down 45 pounds but muscle mass maintained.

Looking into the knee came next…. I started with BPC/TB and then, after more learning, shifted to KLOW. I researched other adjacent supplements and add collagen, glucosamine/chondroitin, and a couple others. I’ve been at it 3 months with leg training and biking.

The results? Two years ago when we were at a ski resort in Canada I could barely make it down a 5 mile green run due to knee and leg pain. I was slowing up my wife, daughter, and FIL. I had to go in early every single day. It was embarrassing.

Flash forward to today and it’s like I pulled 15 years off of my shoulders. I am skiing 5-6 hours every day. Unless I hit something VERY wrong I feel nothing. I’m outskiing my teenager and family like never before. I’ve upped KLOW to morning and evening every day for recovery and I’m waking up with legs feeling good and ready to go.

Just sharing this in case anyone else is wondering if this can make a difference. I still have 3 more days of skiing so we’ll see what happens!

For the future I’m also considering AOD9604 and Cartalax but not ready to commit year. I need to do a lot more reading on both.

 

[RubbaDubba1]

I’ve shared my Selank impact in another post and wanted to share the other part of my knew found appreciation for peptides.

Years ago I took martial arts with my young child rather than sit for hours every week doing nothing. We made blackbelt (strip-mall TKD style but then had some military guys join as the school started teaching BJJ. The classes became a little more cut-throat and in my 40s I was less than happy with some 26 years old infantry guys deciding to go for the knees and easy drops. My knees didn’t appreciate it and neither did I.

It eventually led to meniscus surgery to repair the damage. I trusted the surgeon and he worked wonders on a shredded rotator cuff years before. This time he didn’t warn me that osteoarthritis was a likely outcome and great accelerated. Years later that knee has started to sound like a bowl of rice krispees when I climb stairs. I’ve seen 2 more doctors and all of them question why that surgery was proposed. They also had no other path forward other than injections for a couple years followed by a knee replacement that will last approx 10 years. I only get two of those. I needed to stretch that roadmap out…

After Tirz for weightloss opened my eyes to peptides I started researching support for it. I paid through the nose and got telehealth subscription Rx’s for NAD+ and Semorelin. Those both made a huge difference in my GLP kickstarted weight loss journey to those of my wife and two other friends who started at the same time. The three of them are all down 20%ish in weight but have loss fat/muscle evently. Between those two peptides and working out I’ve managed to lose fat while gaining an equal % of muscle. Effectively down 45 pounds but muscle mass maintained.

Looking into the knee came next…. I started with BPC/TB and then, after more learning, shifted to KLOW. I researched other adjacent supplements and add collagen, glucosamine/chondroitin, and a couple others. I’ve been at it 3 months with leg training and biking.

The results? Two years ago when we were at a ski resort in Canada I could barely make it down a 5 mile green run due to knee and leg pain. I was slowing up my wife, daughter, and FIL. I had to go in early every single day. It was embarrassing.

Flash forward to today and it’s like I pulled 15 years off of my shoulders. I am skiing 5-6 hours every day. Unless I hit something VERY wrong I feel nothing. I’m outskiing my teenager and family like never before. I’ve upped KLOW to morning and evening every day for recovery and I’m waking up with legs feeling good and ready to go.

Just sharing this in case anyone else is wondering if this can make a difference. I still have 3 more days of skiing so we’ll see what happens!

For the future I’m also considering AOD9604 and Cartalax but not ready to commit year. I need to do a lot more reading on both.

Next to the GLP-1's, (PPS) Pentosan Polysulfate Sodium has been the biggest change for me pain wise. It's not a peptide, but has been refurbished from an old bladder medication and it works great on Arthritis. I get it through my Longevity Dr. and the compounded pharmacy he works with. It is a bit of a blood thinner, runs about $250 for a 6 week course and you inject 2X a week. It lasts about a year for most people, I've run 2 courses now, both times after 3 weeks the pain starts back. I can't take regular Arthritis drugs, which is why I looked into this. Think of it, like Cartalax on steroids. It's currently in stage 3 trials in the US & Australia, to bring it too market in the next year or two. They've given it to horses and dogs for a while now and my dog is on it.

I've had both my knees replaced and I'm not much older than you, keeping the weight off was crucial for the replacement - replacement knee 15-20 years down the road. You mentioned a knee replacement only lasting 10 years?

 

[jw717us]

Next to the GLP-1's, (PPS) Pentosan Polysulfate Sodium has been the biggest change for me pain wise.

I've had both my knees replaced and I'm not much older than you, keeping the weight off was crucial for the replacement - replacement knee 15-20 years down the road. You mentioned a knee replacement only lasting 10 years?

I've been reading about PPS and curious. Right now I am personally not working with a longevity friendly doc and the only clinic near me wants to treat it as an elite membership based club. The alternative route that I see folks discuss vet based sourcing and that seems problematic at best.

The knee replacement language was based on what two ortho specialists shared. Not knowing any better I assumed it was gospel. I'll have to look into it. Thanks for the redirect!

 

[igottapee]

It sounds like you're increasing the amount of support for your knees by losing weight and being more active(biking and leg training). My Dr told me about injections. It'll work for x amount of time, then you'll need another which will only help about half as long as the first one, and so on. Also, you'll have to wait 6 months before any type of surgical repair after an injection.

Due to my job, my knees got to grade 4 chondromalacia and required both to have replacements to improve life... and yes, to be pain free. When having them done, there were things/activities that would have to be avoided, stopped or slowed down( in your case, skiing). I did become bowl legged as the cartilage was gone, total bone on bone and after having the replacements done, I stand corrected and probably got about 1.5 inches taller. I wish I would have known about peptides much sooner as 800mg Ibuprofen X3 times a day no longer worked.

Keep up with the biking and leg training and build up those supporting muscles! Put off having surgery(replacements) as long as you can! I truly know what pain is, I'm sure @RubbaDubba1 can attest to that, you only want to have that procedure done once! I was told they last 15-20 years, depending on how active you are. Make sure to check in once you hit your goal weight!

 

[jw717us]

It sounds like you're increasing the amount of support for your knees by losing weight and being more active(biking and leg training). My Dr told me about injections. It'll work for x amount of time, then you'll need another which will only help about half as long as the first one, and so on. Also, you'll have to wait 6 months before any type of surgical repair after an injection.

Due to my job, my knees got to grade 4 chondromalacia and required both to have replacements to improve life... and yes, to be pain free. When having them done, there were things/activities that would have to be avoided, stopped or slowed down( in your case, skiing). I did become bowl legged as the cartilage was gone, total bone on bone and after having the replacements done, I stand corrected and probably got about 1.5 inches taller. I wish I would have known about peptides much sooner as 800mg Ibuprofen X3 times a day no longer worked.

Keep up with the biking and leg training and build up those supporting muscles! Put off having surgery(replacements) as long as you can! I truly know what pain is, I'm sure @RubbaDubba1 can attest to that, you only want to have that procedure done once! I was told they last 15-20 years, depending on how active you are. Make sure to check in once you hit your goal weight!

Sounds like great advice 1st hand. I appreciated it!

 

[Phoenix_Vixen]

I’ve shared my Selank impact in another post and wanted to share the other part of my knew found appreciation for peptides.

Years ago I took martial arts with my young child rather than sit for hours every week doing nothing. We made blackbelt (strip-mall TKD style but then had some military guys join as the school started teaching BJJ. The classes became a little more cut-throat and in my 40s I was less than happy with some 26 years old infantry guys deciding to go for the knees and easy drops. My knees didn’t appreciate it and neither did I.

It eventually led to meniscus surgery to repair the damage. I trusted the surgeon and he worked wonders on a shredded rotator cuff years before. This time he didn’t warn me that osteoarthritis was a likely outcome and great accelerated. Years later that knee has started to sound like a bowl of rice krispees when I climb stairs. I’ve seen 2 more doctors and all of them question why that surgery was proposed. They also had no other path forward other than injections for a couple years followed by a knee replacement that will last approx 10 years. I only get two of those. I needed to stretch that roadmap out…

After Tirz for weightloss opened my eyes to peptides I started researching support for it. I paid through the nose and got telehealth subscription Rx’s for NAD+ and Semorelin. Those both made a huge difference in my GLP kickstarted weight loss journey to those of my wife and two other friends who started at the same time. The three of them are all down 20%ish in weight but have loss fat/muscle evently. Between those two peptides and working out I’ve managed to lose fat while gaining an equal % of muscle. Effectively down 45 pounds but muscle mass maintained.

Looking into the knee came next…. I started with BPC/TB and then, after more learning, shifted to KLOW. I researched other adjacent supplements and add collagen, glucosamine/chondroitin, and a couple others. I’ve been at it 3 months with leg training and biking.

The results? Two years ago when we were at a ski resort in Canada I could barely make it down a 5 mile green run due to knee and leg pain. I was slowing up my wife, daughter, and FIL. I had to go in early every single day. It was embarrassing.

Flash forward to today and it’s like I pulled 15 years off of my shoulders. I am skiing 5-6 hours every day. Unless I hit something VERY wrong I feel nothing. I’m outskiing my teenager and family like never before. I’ve upped KLOW to morning and evening every day for recovery and I’m waking up with legs feeling good and ready to go.

Just sharing this in case anyone else is wondering if this can make a difference. I still have 3 more days of skiing so we’ll see what happens!

For the future I’m also considering AOD9604 and Cartalax but not ready to commit year. I need to do a lot more reading on both.

I’ve shared my Selank impact in another post and wanted to share the other part of my knew found appreciation for peptides.

Years ago I took martial arts with my young child rather than sit for hours every week doing nothing. We made blackbelt (strip-mall TKD style but then had some military guys join as the school started teaching BJJ. The classes became a little more cut-throat and in my 40s I was less than happy with some 26 years old infantry guys deciding to go for the knees and easy drops. My knees didn’t appreciate it and neither did I.

It eventually led to meniscus surgery to repair the damage. I trusted the surgeon and he worked wonders on a shredded rotator cuff years before. This time he didn’t warn me that osteoarthritis was a likely outcome and great accelerated. Years later that knee has started to sound like a bowl of rice krispees when I climb stairs. I’ve seen 2 more doctors and all of them question why that surgery was proposed. They also had no other path forward other than injections for a couple years followed by a knee replacement that will last approx 10 years. I only get two of those. I needed to stretch that roadmap out…

After Tirz for weightloss opened my eyes to peptides I started researching support for it. I paid through the nose and got telehealth subscription Rx’s for NAD+ and Semorelin. Those both made a huge difference in my GLP kickstarted weight loss journey to those of my wife and two other friends who started at the same time. The three of them are all down 20%ish in weight but have loss fat/muscle evently. Between those two peptides and working out I’ve managed to lose fat while gaining an equal % of muscle. Effectively down 45 pounds but muscle mass maintained.

Looking into the knee came next…. I started with BPC/TB and then, after more learning, shifted to KLOW. I researched other adjacent supplements and add collagen, glucosamine/chondroitin, and a couple others. I’ve been at it 3 months with leg training and biking.

The results? Two years ago when we were at a ski resort in Canada I could barely make it down a 5 mile green run due to knee and leg pain. I was slowing up my wife, daughter, and FIL. I had to go in early every single day. It was embarrassing.

Flash forward to today and it’s like I pulled 15 years off of my shoulders. I am skiing 5-6 hours every day. Unless I hit something VERY wrong I feel nothing. I’m outskiing my teenager and family like never before. I’ve upped KLOW to morning and evening every day for recovery and I’m waking up with legs feeling good and ready to go.

Just sharing this in case anyone else is wondering if this can make a difference. I still have 3 more days of skiing so we’ll see what happens!

For the future I’m also considering AOD9604 and Cartalax but not ready to commit year. I need to do a lot more reading on both.

I am pretty similar to you - I have osteoporosis and currently waiting for knee ligament reconstruction, on both knees! High grade 3 tear of my ACL (left knee) and MCL (right knee).

Along with a few other conditions.

I've been looking at the sub for support around Tirz and the more I look the more I'm interested in other peptides that I didn't even know existed to support the other conditions I have.

I've found my T60 supplier, so I will see how that goes when I trust I fully know what I'm doing, and if all goes well, I'll be looking at the other pepts to help with my knee ligaments and muscles. It's hard to do work outs with leg braces at the moment so I've just been trying small 3kg and 5kg weights to build myself up for better health. Better than nothing!

 

[jw717us]

I am pretty similar to you - I have osteoporosis and currently waiting for knee ligament reconstruction, on both knees! High grade 3 tear of my ACL (left knee) and MCL (right knee).

Along with a few other conditions.

I've been looking at the sub for support around Tirz and the more I look the more I'm interested in other peptides that I didn't even know existed to support the other conditions I have.

I've found my T60 supplier, so I will see how that goes when I trust I fully know what I'm doing, and if all goes well, I'll be looking at the other pepts to help with my knee ligaments and muscles. It's hard to do work outs with leg braces at the moment so I've just been trying small 3kg and 5kg weights to build myself up for better health. Better than nothing!

If you are interested I can share the total list of supplements I worked up to support the peptides and a workout schedule. I played around with a couple AIs and spoke with an ortho specialist.

 

[Main75]

If you are interested I can share the total list of supplements I worked up to support the peptides and a workout schedule. I played around with a couple AIs and spoke with an ortho specialist.

I’d be interested in your list …definitely focus on fight arthritis and hoping to promote cartilage

 

[Phoenix_Vixen]

If you are interested I can share the total list of supplements I worked up to support the peptides and a workout schedule. I played around with a couple AIs and spoke with an ortho specialist.

Yeah, a list would be awesome for me to look into.

I'm currently taking tablet supplements, but they aren't doing much. Particularly for the pain and aching.

 

[cowboy54]

If you are interested I can share the total list of supplements I worked up to support the peptides and a workout schedule. I played around with a couple AIs and spoke with an ortho specialist.

I have a full thickness tear on the tibia and have been advised that I will need an HTO in a few years, then when that cartilage wears down it would be knee replacement

Want to avoid that as long as possible, and try to keep running. Ive been an Wolverine stack for the last few months, now interested in KLOW

If you could share your workout that would be great, currently try to take fish oil, mulit vit and glucosamen every day. Gave up chondroitin years ago as not too many studies show any actual benefit

 

[RubbaDubba1]

I've been reading about PPS and curious. Right now I am personally not working with a longevity friendly doc and the only clinic near me wants to treat it as an elite membership based club. The alternative route that I see folks discuss vet based sourcing and that seems problematic at best.

The knee replacement language was based on what two ortho specialists shared. Not knowing any better I assumed it was gospel. I'll have to look into it. Thanks for the redirect!

I had weight loss surgery before and can't take Aleve or Celebrex. Wen I go off the PPS, my Arthritis pain comes back like gang busters. I had done the loading dose, but was on 100 units a week just to maintain. I have to have a Hernia surgery, so I had to go off everything 2 weeks ago and am now realizing how much the PPS does for me. I may have to budget to stay on it full time, this stuff is that good if you do some research on it.

I gottapee is right, hold out on a knee replacement as long as you can. I had mine done very young, in terms of age. I got read the Riot Act about being heavy and getting that 2nd replacement later in life (If I live that long I was almost 600lbs and having found the PPS, is night and day! Best of luck

 

[DjJoshua]

I am also interested in having a peek at your list. I did around 20 years of BJJ and it still hurts to turn my head all the way left and right from practicing getting out of 10 million headlocks lol..BUT I did get to see Al - bundy and what a story that was....

 

[jw717us]

Here is the complete list

UC-II Collagen 40mg daily (9pm) Oral tolerance mechanism suppresses inflammation; 73% improvement in pain/stiffness/function within 90 days Boswellia serrata 300mg daily (75% AKBA) MRI-confirmed cartilage volume and thickness increase; reduces cartilage degradation markers 50-60% Curcumin/Turmeric 500mg daily (Meriva) Chondroprotection via NF-κB inhibition; MRI-confirmed cartilage stiffness/surface improvement at 12 months BPC-157 500mcg SubQ daily (30 days on/14 off) Stimulates collagen II synthesis, angiogenesis, tissue repair; 87.5% knee pain improvement in trials TB-500 500mcg SubQ daily (30 days on/14 off) Angiogenesis, macrophage polarization to tissue repair; pain reduction weeks 1-2, functional restoration weeks 5-8 GHK-Cu 2.5mg SubQ daily (30 days on/14 off) Upregulates collagen/cartilage matrix synthesis; reduces inflammatory cytokines (TNF-α, IL-6) Hyaluronic Acid 250mg oral daily Joint lubrication, synovial health, cartilage hydration; intra-articular injections last 6-12 months per dose Creatine Monohydrate 5g daily (in Huel) Muscle strength (quadriceps/stabilization); indirect joint protection by reducing abnormal loading stress Bovine Collagen Peptides 10g daily (in coffee) Type I/III collagen amino acids; supports general connective tissue; synergistic with UC-II

 

[ronin365]

I strained my Achilles on a hike last summer. It took a while to resolve, and even then, the pain would return on and off if the Achilles was strained during my daily walks or leg days at the gym. After getting on GLOW/KLOW in November last year, I have not had any Achilles pain. Frankly, that surprised me as I didn't expect that quick a resolution, as my dosing has been daily, but at the low end of therapeutic.

 

[Jittrbug]

Here is the complete list

UC-II Collagen 40mg daily (9pm) Oral tolerance mechanism suppresses inflammation; 73% improvement in pain/stiffness/function within 90 days Boswellia serrata 300mg daily (75% AKBA) MRI-confirmed cartilage volume and thickness increase; reduces cartilage degradation markers 50-60% Curcumin/Turmeric 500mg daily (Meriva) Chondroprotection via NF-κB inhibition; MRI-confirmed cartilage stiffness/surface improvement at 12 months BPC-157 500mcg SubQ daily (30 days on/14 off) Stimulates collagen II synthesis, angiogenesis, tissue repair; 87.5% knee pain improvement in trials TB-500 500mcg SubQ daily (30 days on/14 off) Angiogenesis, macrophage polarization to tissue repair; pain reduction weeks 1-2, functional restoration weeks 5-8 GHK-Cu 2.5mg SubQ daily (30 days on/14 off) Upregulates collagen/cartilage matrix synthesis; reduces inflammatory cytokines (TNF-α, IL-6) Hyaluronic Acid 250mg oral daily Joint lubrication, synovial health, cartilage hydration; intra-articular injections last 6-12 months per dose Creatine Monohydrate 5g daily (in Huel) Muscle strength (quadriceps/stabilization); indirect joint protection by reducing abnormal loading stress Bovine Collagen Peptides 10g daily (in coffee) Type I/III collagen amino acids; supports general connective tissue; synergistic with UC-II

I wanted to check on with you and see how things are going. How are your knees doing? I was just diagnosed with arthritis in my right knee last week and am determined to do what I can to help it so we don't get to surgery any time soon.

 

[jw717us]

I wanted to check on with you and see how things are going. How are your knees doing? I was just diagnosed with arthritis in my right knee last week and am determined to do what I can to help it so we don't get to surgery any time soon.

Ok I've been away due to house projects and new job and juuuuuust have spare time to come back around.

I'm happy that I'm holding/improving. Overall kneed strength and stability is way back up. Winter ski season was phenomenal. I still have crepitis in one knee when climbing stairs.

Earlier this month I took a spill and landed both kneeds fairly hard on concrete. I went in to a same day ortho place and they took a full set of xrays of both knees. Comparison of the xrays this month to last February show they are stable with no perceived progression of OA.

I have a follow-up with a doctor next month. I'm considering bringing up PPS or Cartalax to see if there is anything else I can bring in to slow, or maybe even reverse, the trend. At 53 after the multiple meniscus tears I'll take what I can get.

 

[CheesyPotato]

Hi

Ok I've been away due to house projects and new job and juuuuuust have spare time to come back around.

I'm happy that I'm holding/improving. Overall kneed strength and stability is way back up. Winter ski season was phenomenal. I still have crepitis in one knee when climbing stairs.

Earlier this month I took a spill and landed both kneeds fairly hard on concrete. I went in to a same day ortho place and they took a full set of xrays of both knees. Comparison of the xrays this month to last February show they are stable with no perceived progression of OA.

I have a follow-up with a doctor next month. I'm considering bringing up PPS or Cartalax to see if there is anything else I can bring in to slow, or maybe even reverse, the trend. At 53 after the multiple meniscus tears I'll take what I can get.

Hi I was wondering how did your follow up go? Did you bring up the PPS and/or Cartlax?

I have to have the same conversation with my Ortho. Although, a couple of weeks ago, I went ahead and started Cartlax/TB/BP and most of the supplements shared in this thread. I'm sure I'm going to get scolded for not consulting with him first.

 

[jw717us]

Hi

Hi I was wondering how did your follow up go? Did you bring up the PPS and/or Cartlax?

I have to have the same conversation with my Ortho. Although, a couple of weeks ago, I went ahead and started Cartlax/TB/BP and most of the supplements shared in this thread. I'm sure I'm going to get scolded for not consulting with him first.

I haven't yet. Just had my annual checkup and they are running full blood panels. I'll be curious to compare to October.

 

[AgingRegenDamaged]

I haven't yet. Just had my annual checkup and they are running full blood panels. I'll be curious to compare to October.

I intend to take Cartalax and KLOW together because I am sure the latter will help with the former.

I was thinking of adding a weight loss peptide because of this:

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