Weight loss plateau and amycretin

[gpwdeux]

I am surprised there hasn't been more talk about this med. One of the most talked about "downsides" I hear people talk about is the frustration with the plateaus

https://www.fiercebiotech.com/biotech/novos-injectable-amycretin-yet-hit-weight-loss-plateau-suggesting-zepbound-beating

 

[keangkong]

Amycretin sounds extremely promising. By week 36, on average, people taking the injectable version has lost 24 percent of their bodyweight compared to 1 percent on placebo. My recollection is that on the highest dose of retatrutide, it took until week 48 to see similar results. Thus, based upon this early study, it looks like Amycretin may be superior in weight loss to Reta.

Malesu, Amycretin delivers unprecedented weight loss in early trial for obesity treatment

Here is the no paywall scholarly article: Dahl, et al. Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously - results from a phase 1b-2a randomised controlled study. Lancet (Published online 2025-06-21) .

Here is the no paywall Wall Street Journal version: Chopping (Jun. 23, 2025). Novo Nordisk’s New Obesity Drug Beats Wegovy Weight Loss in Early Trial - The drugmaker is racing to develop the next generation of obesity medicines (Wall Street Journal).

Oddly, there was no much of a difference in weight loss between those who injected 20 mg per week and those who injected 60 mg per week.

Weight reduction was rapid, dose-dependent, and sustained. At their respective end-of-treatment timepoints, estimated mean percentage losses from baseline were:

24.3% with 60 mg (week 36)

22.0% with 20 mg (week 36)

16.2% with 5 mg (week 28)

9.7% with 1.25 mg (week 20)

 

[ohemaaluxe]

Amycretin sounds extremely promising. By week 36, on average, people taking the injectable version has lost 24 percent of their bodyweight compared to 1 percent on placebo. My recollection is that on the highest dose of retatrutide, it took until week 48 to see similar results. Thus, based upon this early study, it looks like Amycretin may be superior in weight loss to Reta.

Malesu, Amycretin delivers unprecedented weight loss in early trial for obesity treatment

Here is the no paywall scholarly article: Dahl, et al. Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously - results from a phase 1b-2a randomised controlled study. Lancet (Published online 2025-06-21) .

Here is the no paywall Wall Street Journal version: Chopping (Jun. 23, 2025). Novo Nordisk’s New Obesity Drug Beats Wegovy Weight Loss in Early Trial - The drugmaker is racing to develop the next generation of obesity medicines (Wall Street Journal).

Oddly, there was no much of a difference in weight loss between those who injected 20 mg per week and those who injected 60 mg per week.

Weight reduction was rapid, dose-dependent, and sustained. At their respective end-of-treatment timepoints, estimated mean percentage losses from baseline were:

24.3% with 60 mg (week 36)

22.0% with 20 mg (week 36)

16.2% with 5 mg (week 28)

9.7% with 1.25 mg (week 20)

I was kind of thrown off at first by the 60mg dose since that’s so much higher than what we usually see with drugs like sema (2.4mg) or tirz (15mg). But I’m guessing that has more to do with how amycretin is structured and how potent it is — especially since it’s combining a GLP-1 mimic with amylin? Different compounds probably just require different dosing to be effective. Either way, super curious to see how this one plays out!

 

[Tinkerbell2222]

I am very curious also will be on the lookout for more on amycretin!

 

[Dogmandu]

The peptide sequence and structure etc is published and in the public domain. Not sure how long it's been that way, but is it odd that regular sources are not already offering this?

 

[Galapagosfit]

is someone have already found oral amycretin on a grey vendor list or it's not released yet?