Unexpected appetite suppression

[Researcher6076]

My weight loss journey started with Sema, then Tirz, now combined Tirz + Reta. I’m near goal and titrating down slowly and using Tirz + Reta to change my relationship with food. I’ve been at 2mg Tirz and 4mg Reta for a couple of months and thinking I can go down.

For the last two weeks I’ve experienced extreme appetite suppression. It’s like I’m on double my dose! No nausea, vomiting, constipation, diarrhea. No bad sides, just extreme appetite suppression. I have to force myself to eat.

One possible explanation is I did recently reconstitute a new vial of Tirz. Of course, now that I’m trying to remember, I am not sure the appetite suppression coincided with the new vial at all. Maybe the old vial had degraded in my fridge, but I did not feel like the old vial wasn’t working. Maybe the new vial had more mg than labeled.

While those ideas are my best guess, I’m just wondering if anyone else has ever experienced unexplained appetite suppression on SG1s.

 

[CNCCurrency]

Maybe an over fill and your dose was stronger than you thought?

 

[lessthanhalf]

The first thing to check is your maths. Even if you have been doing it for a while it is just so easy to make a basic error in calculating dilutions and doses. Maybe double check then triple check with one of the peptide calculator websites. And do this for both peptides. Is it possible to mix up a vial of reta with a vial of tirz?

Otherwise, no obvious clues as to why. If you have any from a different batch try that. Generally after weight loss as you are getting near your goal, you should get more hungry not less. As you say it is 2 weeks it is not likely you are coming down with a virus.

If you do not have a different batch to try of tirz, you could try a smaller dose , it might have a different effect, but it does not make a lot of sense, even if the dose was out by 100%, taking 4 vs 2mg of tirz per week , while already on 4mg of reta is close to the line where you might not even notice the difference. The reta dose being out by 100% ( 8mg instead of 4 ) would be obvious , but if you are using the same batch/vial/dilution it would be nearly impossible.

 

[Researcher6076]

TY for the thoughtful reply with some ideas. I 100% agree with all those possibilities. It is a new vial from a new lot. Pretty much all possibilities are on the table. My math is right if the mg labels are on the vials are correct. Everything is done via excel so it’s not my math, just me plugging in the number might be the source of that error, and I've double checked that. There's always a chance I made one error drawing into a syringe. But this is a couple of weeks, and my doses split the weeks, so I’ve had at least three doses. I’m pretty sure something is wrong somewhere. This mystery may go unsolved, LOL. I skipped by doses yesterday and plan on resuming day after tomorrow.

The first thing to check is your maths. Even if you have been doing it for a while it is just so easy to make a basic error in calculating dilutions and doses. Maybe double check then triple check with one of the peptide calculator websites. And do this for both peptides. Is it possible to mix up a vial of reta with a vial of tirz?

Otherwise, no obvious clues as to why. If you have any from a different batch try that. Generally after weight loss as you are getting near your goal, you should get more hungry not less. As you say it is 2 weeks it is not likely you are coming down with a virus.

If you do not have a different batch to try of tirz, you could try a smaller dose , it might have a different effect, but it does not make a lot of sense, even if the dose was out by 100%, taking 4 vs 2mg of tirz per week , while already on 4mg of reta is close to the line where you might not even notice the difference. The reta dose being out by 100% ( 8mg instead of 4 ) would be obvious , but if you are using the same batch/vial/dilution it would be nearly impossible.

TY for the thoughtful reply with some ideas. I 100% agree with all those possibilities. It is a new vial from a new lot. Pretty much all possibilities are on the table. My math is right if the mg labels are on the vials are correct. Everything is done via excel so it’s not my math, just me plugging in the number might be the source of that error, and I've double checked that. There's always a chance I made one error drawing into a syringe. But this is a couple of weeks, and my doses split the weeks, so I’ve had at least three doses. I’m pretty sure something is wrong somewhere. This mystery may go unsolved, LOL. I skipped by doses yesterday and plan on resuming day after tomorrow.

 

[lessthanhalf]

It is actually possible that they made an error and what is actually in the vial is different to what it says, though I think finding an error on triple checking is still more likely, though it sounds like you have checked this issue pretty well. The dose would have to be off by a factor of 2 or more, or be a different drug to have the effect you describe. I am really surprised at how rare this is, the vendors are not pharma companies that have lots of rules and inspection processes and a entirely necessary obsessive safety based approach, the vendors can't be sued or charged with manslaughter or assault no matter how bad they stuff up. The only force I can see generating quality control is their personal ethics ( which would seem to be a possibly unreliable mechanism ) , and not wanting bad posts on forums like this or getting really busted by test results that prove serious errors in dosing or labelling, given the large number of alternative options the loss in sales from such events could be very large - millions easily.

Was it a new vendor for you? well known? been around a while? with at least some third party test results somewhere online? If one in a batch is not right then it is safe to assume they all are, so using a different vial from the same kit won't help.

There have been a few cases on here , one where reta and semaglutide or tirz were somehow mixed together, which got a lot of attention and a recall, and I found a single case study where a woman in Italy ended up in a coma after an injection of what turned out to be insulin from a vial labelled semaglutide, although as pointed out by someone else here that does not make much sense in that there should have been a lot more cases, not one and raises questions about it being a deliberate substitution and possible murder attempt.

It is definitely possible it is just an odd response, a physiological quirk, where you got less hungry for a while for no easily explainable reason.

The only way to know for sure is to send one off for testing, but almost certainly cheaper and quicker to buy another lot from a different source. Or just assume the dose is off and use a lower dose of it. It basically cannot be anything except a glp drug given the effect on appetite. No other drugs really have such clear and major effects on appetite.

 

[Foggy-Hollow]

It is a new vial from a new lot. Pretty much all possibilities are on the table. My math is right if the mg labels are on the vials are correct.

Double check your COAs, they have fill volume on them. Statistically it’s a best guess but it’s the best we have for an educated guess.

If the last vial was barely filled and the new vial really over-filled which a few vendors tend to habitually do- then yes the new vial would be quite punchy. Some overfill quite a bit.

Since gray isn’t highly regulated the vials aren’t going to be super consistent especially one manufacturer to another even at the “same” mg.

 

[itsmenotyou]

I have days like that too - actually most days.. i am on 1mg.. Weird thing is i force myself to eat things i shouldn't eat - eg i got given some aussie chocolates the other day and i know i really like them i wasn;t hungry but ate them all.. so i could go a whole day only eating just the chocoltes. I need to get my diet in check asap.