Titrate - How much to increase?

[itsmenotyou]

I agree that pushing it to the point of feeling sick doesn’t make sense if you aren’t in a rush. I haven’t seen anything to convince me that a slow escalation has any other trade off than slower progress.

Thanks for insight - i ended up going with 1.5

 

[itsmenotyou]

From what I have seen on this forum, and I have seen no evidence of this in the studies, people trying to lose relatively small amounts of weight, who are not severely obese at the start , seem to get more side effects and more effects at lower doses , than I would expect. And the research is not that helpful as most people were more overweight in the studies. There is no doubt at all that the metabolic state in severe obesity is quite different in a lot of ways , so it sort of makes sense.

I cranked the dose of tirz from 1mg to 15 in a month, without issues, no I am not recommending it, but I had already lost 70 kg at that point.

For the OP the fact that calorie intake dropped to 600 /day when you started at 1mg suggests you are pretty sensitive to the drug, so being more careful is probably sensible. Worse side effects are always possible with any dose increase at any stage, but increasing slowly probably is likely to make them less sudden or severe. If you did not notice the effects increasing over the last 4 weeks, then if you increase to 1.5mg and you still have no side effects and are still hungry then you probably do not need to wait 4 weeks to increase to 2mg, 2 weeks is probably fine, given that 2mg is the standard starter dose and not thought by the company that makes the drug to be risky.

Thank you!! i did 1.5mg today - will do it for 2 weeks then reasses and go to 2 if need

 

[Turnus]

Just curious, any issues after the increase?

 

[BNLFL]

Jumped to 8mg on Friday in a new batch of MLB R50. I can really feel this one in a couple different ways, good ways. The scale readout after 4 days was interesting.

 

[itsmenotyou]

Jumped to 8mg on Friday in a new batch of MLB R50. I can really feel this one in a couple different ways, good ways. The scale readout after 4 days was interesting.

wow 8mg! thats huge. Glad its working for you

 

[itsmenotyou]

Just curious, any issues after the increase?

I went 1.5mg and noticed food noise going away - but heartburn and upset stomach last few days... but nothing stopping me from daily life.

 

[msyntakz]

I have been wanting to move my reta dose up to at least the 4mg dose from 2mg, but I decided to only move .5mg. I am so glad I didn't do more. Felt like a brick wall of food noise suppression, heartburn, and dopamine blocking. I seem to be sensitive to this stuff.

 

[itsmenotyou]

I have been wanting to move my reta dose up to at least the 4mg dose from 2mg, but I decided to only move .5mg. I am so glad I didn't do more. Felt like a brick wall of food noise suppression, heartburn, and dopamine blocking. I seem to be sensitive to this stuff.

The heartburn is crazy at night.. feel like i am pregnant again!

the dopamine blocking is real. I had a few days i struggled ot do much other than doomscroll.. glad that is over...

 

[domin8brix]

Currently on 1mg - have been for 6 weeks. Tomorrow is dose day and I am thinking I should increase. This last week or so I have had a lot of food noise and eating way more than I had done the weeks before. (When i first started I was struggling to eat 600 calories a day now I could easily eat 2000 without thinking).

My question is - should I go to 1.5mg or 2mg? And what is the basis for deciding?

I am of the mind where you go up to maybe 1.25mg--I go up literally a unit at a time--so if I am taking 10u to be at 2mg, go up 1 unit at a time over a few weeks.

 

[itsmenotyou]

I am of the mind where you go up to maybe 1.25mg--I go up literally a unit at a time--so if I am taking 10u to be at 2mg, go up 1 unit at a time over a few weeks.

Thanks I went from 1.0 to 1.5 will try this for a couple of weeks and see how i go!

 

[IMT11]

Currently on 1mg - have been for 6 weeks. Tomorrow is dose day and I am thinking I should increase. This last week or so I have had a lot of food noise and eating way more than I had done the weeks before. (When i first started I was struggling to eat 600 calories a day now I could easily eat 2000 without thinking).

My question is - should I go to 1.5mg or 2mg? And what is the basis for deciding?

glad i found this thread, I am on week 5 of 1mg (starting dose) and this week noticeably hungrier and more food noise vs the previous 4 weeks so was thinking about moving up and had the same debate if I should go to 1.5 or 2. Think I will go to 1.5 and take it from there.

Any update on your end?

 

[TastyBlack]

glad i found this thread, I am on week 5 of 1mg (starting dose) and this week noticeably hungrier and more food noise vs the previous 4 weeks so was thinking about moving up and had the same debate if I should go to 1.5 or 2. Think I will go to 1.5 and take it from there.

Any update on your end?

Same here, on 1mg for 3 weeks and hunger is starting to creep back so I'm doing the same as you, upping to 1.5mg. Take it slow.

When I was on Tirz, I went from 2.5 to 5 and it kicked my ass big time! Titrated up too far in one jump so I've learned my lesson, ease into it.