ZippityDooDah
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https://investor.lilly.com/news-releases/news-release-details/tirzepatide-reduced-sleep-apnea-severity-nearly-two-thirds
Tirzepatide shown to help reduce sleep apnea severity.
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LizbethinEdmonds
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Amazing!ZippityDooDah said:
dionysos
GLP-1 Novice
I've used a CPAP successfully for several years to treat my severe sleep apnea .
With CPAP therapy my 62 Obstructive Sleep Apneas per Hour (untreated) is reduced to a very, very low 0.4 OSA/hour.
Semaglutide has enabled me to lose over 20% of my bodyweight in the past year.
Now I use 38% LESS PRESSURE and keep my OSAs NEAR ZERO!
Those who don't use CPAP won't know this but a 38% reduction in mask pressure is a HUGE amount.
I've spent the past month transitioning to Tirzepatide @ 7.5mg weekly.
Will Tirz decrease my OSAs and allow further pressure reductions? I'll keep you updated
With CPAP therapy my 62 Obstructive Sleep Apneas per Hour (untreated) is reduced to a very, very low 0.4 OSA/hour.
Semaglutide has enabled me to lose over 20% of my bodyweight in the past year.
Now I use 38% LESS PRESSURE and keep my OSAs NEAR ZERO!
Those who don't use CPAP won't know this but a 38% reduction in mask pressure is a HUGE amount.
I've spent the past month transitioning to Tirzepatide @ 7.5mg weekly.
Will Tirz decrease my OSAs and allow further pressure reductions? I'll keep you updated
Sally-Matilda
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This is an interesting article, but I'm thinking that it's not so much the tirz that's directly causing fewer OSAs, but the fact that subjects lost 20% of their weight. What I'd really like to see is the same study repeated with subjects who lost that amount of weight via other meds or gastric bypass, etc.
Sally-Matilda
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This is a fantastic result - congratulations!dionysos said:I've used a CPAP successfully for several years to treat my severe sleep apnea .
With CPAP therapy my 62 Obstructive Sleep Apneas per Hour (untreated) is reduced to a very, very low 0.4 OSA/hour.
Semaglutide has enabled me to lose over 20% of my bodyweight in the past year.
Now I use 38% LESS PRESSURE and keep my OSAs NEAR ZERO!
Those who don't use CPAP won't know this but a 38% reduction in mask pressure is a HUGE amount.
I've spent the past month transitioning to Tirzepatide @ 7.5mg weekly.
Will Tirz decrease my OSAs and allow further pressure reductions? I'll keep you updated
dionysos
GLP-1 Novice
HOL UP!
I don't see that this study reveals the effect of Tirzepitide alone on AHI (OSAs)
as distinct from the effect of bodyweight reduction alone on OSAs.
SURMOUNT 2 - CPAP USERS AHI CHANGE 52nd WEEK BODYWEIGHT CHANGE % Tirzepatide -30.4 -20.1 Placebo
-2.3 %
-2.3 %
Quite the contrary finding I think.
SURMOUNT 2 - CPAP USERS
BODYWEIGHT CHANGE % AHI CHANGE % Tirzepatide -20.1 -62.8 Placebo -2.3 -6.3
CPAP users who received a Placebo and lost 2.3% of their bodyweight during the study
had a 6.3% reduction in OSA. I would say this study indicates suggests that bodyweight reduction alone reduces AHI.
Certainly Tirzepatide makes weight loss far easier to achieve, and I am grateful for that! However, let's not oversell the benefits.
I'm a CPAP user who lost 20% bodyweight using (primarily) Semaglutide. I doubt that switching to Tirzepatide will provide ADDITIONAL OSA reduction apart from that achieved by further weight loss. There is no evidence in this study to persuade me that it would.
Said differently: IMO at my goal weight, in maintenance at a fixed weight, and experiencing a consistent measured rate of OSAs - switching to Tirzepitide from Semaglutide would cause no reduction in OSAs.
I don't see that this study reveals the effect of Tirzepitide alone on AHI (OSAs)
as distinct from the effect of bodyweight reduction alone on OSAs.
SURMOUNT 2 - CPAP USERS AHI CHANGE 52nd WEEK BODYWEIGHT CHANGE % Tirzepatide -30.4 -20.1 Placebo
-2.3 %
-2.3 %
Quite the contrary finding I think.
SURMOUNT 2 - CPAP USERS
BODYWEIGHT CHANGE % AHI CHANGE % Tirzepatide -20.1 -62.8 Placebo -2.3 -6.3
CPAP users who received a Placebo and lost 2.3% of their bodyweight during the study
had a 6.3% reduction in OSA. I would say this study indicates suggests that bodyweight reduction alone reduces AHI.
Certainly Tirzepatide makes weight loss far easier to achieve, and I am grateful for that! However, let's not oversell the benefits.
I'm a CPAP user who lost 20% bodyweight using (primarily) Semaglutide. I doubt that switching to Tirzepatide will provide ADDITIONAL OSA reduction apart from that achieved by further weight loss. There is no evidence in this study to persuade me that it would.
Said differently: IMO at my goal weight, in maintenance at a fixed weight, and experiencing a consistent measured rate of OSAs - switching to Tirzepitide from Semaglutide would cause no reduction in OSAs.
dionysos
GLP-1 Novice
That's interesting to hear.toologic said:
I wonder why Tirz would reduce insomnia?
In addition to OSA, I can see so many more trials being put in place for the beneficial effects of tirz that would show statstical significance. Somethings such as reducing the incidence of colon cancer, albeit it is hard to identify whether this is due to tirz as the medication or just reducing overall caloric intake. In any case, amazing things to come.
dionysos
GLP-1 Novice
Yes indeed! Cardiac improvements with Tirz as well!!
Sleep improvement is thought to be due to the effect on the sleep wake cycle. I read an article about it when I was researching fatigue with tirzepatide. I will try to find it again and link it. I am worthless for two days post injection d/t fatigue
dionysos
GLP-1 Novice
Did your research into Tirz fatigue have anything to say about improvements from Stacking Reta or transitioning entirely to Reta?adria37 said:
Reta adds a glucagon receptor agonist and the liver is full of them. Reta promotes fibrolysis in the liver. NASH or non alcoholic steatohepatitis leads to cirrhosis and hepatocellular cancer. Reta is going to be big because it reverses fatty liver. You know what I do and this is really big between weight loss, diabetes, and fatty liver. If you buy stock I would definitely buy this company's stock - Eli Lilly
Edited to add: No on helping with fatigue.
Edited to add: No on helping with fatigue.
Do you do a sleep study every so often or are you tracking Apnea events another way? I also have it and use a CPAP but Id like to know how much it has improved with weight loss.dionysos said:I've used a CPAP successfully for several years to treat my severe sleep apnea .
With CPAP therapy my 62 Obstructive Sleep Apneas per Hour (untreated) is reduced to a very, very low 0.4 OSA/hour.
Semaglutide has enabled me to lose over 20% of my bodyweight in the past year.
Now I use 38% LESS PRESSURE and keep my OSAs NEAR ZERO!
Those who don't use CPAP won't know this but a 38% reduction in mask pressure is a HUGE amount.
I've spent the past month transitioning to Tirzepatide @ 7.5mg weekly.
Will Tirz decrease my OSAs and allow further pressure reductions? I'll keep you updated
dionysos
GLP-1 Novice
I have a Resmed VAuto 10. Like many CPAP machines it keeps a record of its use in an enclosed mini-USB Card. There is a free sofware package called Oscar that can read the data and produce quite detailed reports like the one below. Runs on PCs and Macs.elaine77 said:
Attachments
dionysos
GLP-1 Novice
Yes I think so!catdog said:
A few years back some of the boffins on CPAPTalk.com had implemented a USB WiFi enabled card system. Standard component mounted on a CPAP machine transmitted to a laptop/desktop without the need to physically move the USB drive. Very nice!
Ok, interesting. I have the Resmed Airsense 10. I dont think mine has the mini-Card but Ill have to check for sure. Id also like to know where Im at with no CPAP usage at all without paying a bargeload for a sleep study.dionysos said:
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