Tirzepatide higher doses

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Interesting take on receptors… if receptors don’t fatigue, why is dose escalation typically required to maintain efficacy?

My thought is he’s 50-100% below a therapeutic dose of Reta. Reta has roughly 1/10th the glp exposure as sema. Getting to a therapeutic dose of Reta would give him the benefits of glucagon, with approximately appropriate glp exposure. Split dosing would reduce the peak exposure while maintaining the average exposure. Without getting the benefit of typically therapeutic levels of glucagon, why take Reta over Tirz?

Requiring higher doses to get higher weight loss isn't receptor burnout, its the maximum effect for a given dose. If the receptors were burned out you'd eventually gain back all the weight on the same dose and that doesn't happen.

The therapeutic dose is the dose that is working. It's different for everyone. Splitting your dose is something to possibly consider when the side effects are troublesome. Otherwise stick to what works. There is good reason to believe (especially with reta) that split dosing could be less effective. But that's not proven in any way.