Tirzepatide - A short summary

[Sheldor]

What is Tirzepatide? ​
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Tirzepatide is a medication that belongs to a class known as GLP-1 and GIP receptor agonists. It works by improving blood sugar control and suppressing appetite, which can help with weight loss.

Mounjaro and Zepbound – What’s the Difference? ​
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Mounjaro : Primarily used for the treatment of type 2 diabetes to help control blood sugar. It is injected once a week and often results in weight loss as a side effect.

Zepbound : Specifically approved for weight loss and contains a higher dosage of Tirzepatide. It is also administered as a weekly injection.

Standard Dosage for Weight Loss (Zepbound) ​
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Like other similar medications, the dosage starts low and gradually increases to reduce the risk of side effects:

Week 1-4 : 2.5 mg per week

Week 5-8 : 5 mg per week

Week 9-12 : 7.5 mg per week

Week 13-16 : 10 mg per week

Week 17-20 : 12.5 mg per week

Week 21+: 15mg (target dose)

Possible Side Effects ​
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Tirzepatide can also cause side effects, and here are some potential ones:

Nausea and vomiting

Diarrhea or constipation

Fatigue

Abdominal pain

Loss of appetite

Gallstones (with long-term use)

Injection site reactions (for injections)

For more detailed information about Semaglutide , you can visit the Tirzepatide Wikipedia article.

 

[keangkong]

I believe that there is an intermediate dose of 12.5 mg between the 10 mg and 15 mg doses. Also, upping the dose is not always necessary after a person reaches 5 mgs per week. Dosage is once per week; I take it in half the dose twice per week, but I'm a weirdo.

 

[Sheldor]

I believe that there is an intermediate dose of 12.5 mg between the 10 mg and 15 mg doses.

Thanks, this I have missed, added it to the schedule.

Also, upping the dose is not always necessary after a person reaches 5 mgs per week.

I understand, but this thread was created to give new users a brief overview based on the standard. I’m not sure how we should organize the different schedules. Maybe we could have a general thread since it’s relevant for all GLP-1 procedures.

 

[Jailbreak7]

Why does it say that Zep has higher dose of Tirzepatide in it? it doesn't.. they are same and dosing is same (2.5mg - 15mg in 2.5mg steps).

 

[moonpies4misfits]

Why does it say that Zep has higher dose of Tirzepatide in it? it doesn't.. they are same and dosing is same (2.5mg - 15mg in 2.5mg steps).

Zep has a higher dosage than Mounjaro. Diabetes dosing is different than weight loss dosing.

Edit: Actually I just looked it up and seems you're correct. I could have sworn dosing was different for diabetes. Maybe I'm confusing it with Ozempic.

 

[Sheldor]

Zep has a higher dosage than Mounjaro. Diabetes dosing is different than weight loss dosing.

Edit: Actually I just looked it up and seems you're correct. I could have sworn dosing was different for diabetes. Maybe I'm confusing it with Ozempic.

If you have Diabetes, you stay longer on a lower dosage, as long as your blood sugar stays low. Sorry for not clear text

 

[Jailbreak7]

If you have Diabetes, you stay longer on a lower dosage, as long as your blood sugar stays low. Sorry for not clear text

Technically this is true for Zep as well.. neither needs to be titrated up unless necessary.. Having said that, it's not unheard of doctors pushing up all the way to max dose (for no reason) month by month.. without checking if it's needed..

 

[keangkong]

Technically this is true for Zep as well.. neither needs to be titrated up unless necessary.. Having said that, it's not unheard of doctors pushing up all the way to max dose (for no reason) month by month.. without checking if it's needed..

I'm speaking only as to weight loss since I don't have diabetes. You (or at least if your reaction is similar to those of the people in the trials) will lose more weight if you take a higher dose of tirzepatide. If your goal is to lose as much weight as you can, then yes, go up to 15 mg (in consultation with your doctor and following the dose escalation regimen). However, tirzepatide is the most powerful drug FDA approved drug for weight loss. (In 5-10 years, everyone will say how weak it is compared to what we'll have then.) You may not need to take it at its highest dose. Also, you have to consider side effects too. But I do note that the Zepbound US Prescribing Information webpage doesn't show that much of a difference in side effects between taking 5 mg and 15 mg. Generally, the side effects ease over time. I know that official prescribing information can be boring, but it contains a great deal of useful information.