Tirz never worked

[dk2001]

My brother has been on Tirz for a year and a half. He folll the dosing guide all the way up to 15 mg. He barely lost any weight. His job is a lot of sitting and he doesn't work out religiously but does when he can. We're not sure if we should stack something like ipa/cjc or switch to reta. Looking for advice. Overall he's a bigger guy, you can see he's muscular but still carrying fat.

 

[spanky2026]

Before you add anything I'd look at what he's doing WITH the Tirz, it's a tool but you have to use it properly.

 

[HereKittyKitty]

That sounds really frustrating. There's not a lot of detail in the post about caloric intake, macros, hydration, etc.

 

[Jfrick11]

My brother has been on Tirz for a year and a half. He folll the dosing guide all the way up to 15 mg. He barely lost any weight. His job is a lot of sitting and he doesn't work out religiously but does when he can. We're not sure if we should stack something like ipa/cjc or switch to reta. Looking for advice. Overall he's a bigger guy, you can see he's muscular but still carrying fat.

Has he had a deep dive of labs? Things like insulin resistance, thyroid function, cortisol levels, inflammation, testosterone, sleep quality/sleep apnea, etc. can all play a huge role in whether someone responds well to these meds. Some people go all the way up on tirz and still barely move the scale because there’s another metabolic issue underneath it all.

 

[skaylife]

My brother has been on Tirz for a year and a half. He folll the dosing guide all the way up to 15 mg. He barely lost any weight. His job is a lot of sitting and he doesn't work out religiously but does when he can. We're not sure if we should stack something like ipa/cjc or switch to reta. Looking for advice. Overall he's a bigger guy, you can see he's muscular but still carrying fat.

Trying reta or other glp agonists may possibly help. But I don't think adding Ipa+cjc stack does any sense at this stage. It can help together with some active training. But won't help burning fat without any activity. He will get more hunger together with usage of this stack.

Tried 3 weeks reta after 7 months of mounjaro use under prescription. But reta, ipa+cjc combination was total useless for me. I had hunger all the time. It is back to normal since I am back to tirz. That is my experience. But results can differ from person to person.

I have started ipa to prevent my muscles after 20 weeks of mounjaro treatment and added CJC No Dac 3 weeks ago.

SW:101kg LW:24 kg in 31 weeks. I have reached my GW. Using tirz and ipa+cjc for maintenance at the moment.

 

[CandyCap]

IMHO, everyone is always so quick to add something new or switch.

Look at the basics:

Weight loss does not happen unless you are eating in a calorie deficit.

GLPs are not magic. You still have to take responsibility for what you are eating.

What does your diet look like?

 

[jordekorn]

I recommend calorie tracking, every sauce, every pat of butter, cooking oil, everything. You start to see how it adds up. You make a chicken sandwich, thinking chicken is good for you, but you got 300 calories in bread and 400 calories in mayo. I lost weight, slowly, but I had to track calories, and stay at about 1200 calories at 200 pounds. I also do not work out, but have an active job.

 

[toologic]

I did not respond to Tirz. I see so many comments about its a tool and you still need to exercise and have a calorie deficit. I get that. But I was under the impression that Tirz is supposed to aid in reducing food noise and hunger so it makes it easier to eat less. If Tirz is not suppressing food noise then what is the point in taking it and how is it a tool at that point? I can still exercise and eat a calorie deficit without Tirz and it would be the healthier way to go.

 

[lessthanhalf]

Unfortunately there are some people, about 5 to 10% who lose little weight on GLP drugs. One of the posts not long ago gave a graph of weight loss distributions that showed this pretty clearly. Despite the stuff about tracking calories etc, these drugs are meant to work without that and do in most people, mostly just by making you less hungry so you eat less, which causes the needed calorie deficit. I am not sure that any effort made to make the situation more like a standard diet and exercise program is really going to help, as in the long term, they are really not that effective. And over a year is a pretty good trial. The only options to try would be reta or preferably cagri, reta as it works on glucagon as well, and cagri as it works via amylin receptors, and even if activating GLP-1 and GIP does not work, it does not mean that amylin or glucagon won't. There will hopefully eventually be good research on GLP non responders, but nothing much yet.

 

[Hawk_recon]

I did not respond to Tirz. I see so many comments about its a tool and you still need to exercise and have a calorie deficit. I get that. But I was under the impression that Tirz is supposed to aid in reducing food noise and hunger so it makes it easier to eat less. If Tirz is not suppressing food noise then what is the point in taking it and how is it a tool at that point? I can still exercise and eat a calorie deficit without Tirz and it would be the healthier way to go.

This is pretty much how I felt about Reta after about week 3. It was like it just stopped working. Dosage changes made no difference. I’ve recently started Tirz and can already feel more than I did on Reta, so I’m hopeful that’s the ticket. It’s so interesting how differently people react to each one. For some Reta is a miracle. But it really seems so individual.

 

[dk2001]

Has he had a deep dive of labs? Things like insulin resistance, thyroid function, cortisol levels, inflammation, testosterone, sleep quality/sleep apnea, etc. can all play a huge role in whether someone responds well to these meds. Some people go all the way up on tirz and still barely move the scale because there’s another metabolic issue underneath it all.

He hasn't that I know of. I'll bring that up to him, thanks

 

[bay_area_schizo]

where's he getting his tirz from

 

[randompersonrandom]

Also, there's kind of two factors when it comes to eating in a calorie deficit; there's how much you're eating (like how much food you're putting into your face) and there's how calorically dense the food you're eating IS.

I figured if I kept one or the other low, the weight would come off, and for a good long while it did. Til it didn't anymore, and I had to sigh and start making sure BOTH of those things were fairly low to moderate.

 

[dk2001]

where's he getting his tirz from

China vendors but all has been tested

 

[tendency]

I did not respond to Tirz. I see so many comments about its a tool and you still need to exercise and have a calorie deficit. I get that. But I was under the impression that Tirz is supposed to aid in reducing food noise and hunger so it makes it easier to eat less. If Tirz is not suppressing food noise then what is the point in taking it and how is it a tool at that point? I can still exercise and eat a calorie deficit without Tirz and it would be the healthier way to go.

100% - when these meds work you don't, at least IME and several others I know who've used them, need to worry too much about calories, macros, exercising etc. You simply have no interest in food, are barely able to eat, are stuffed all the time etc. If anything it's the opposite - having to force oneself to consume some calories.

I'd say if you're one of the unlucky ones that take these and STILL need to count calories they're not working very well for you.

 

[miss-sanne]

Some people don't need to count calories, and when it works, it works so well. ( for me and others anyway)

But some people don't respond to glp's, and some don't respond to one glp, but another.

I had zero changes with sema during a year, but with tirz it started to change.

If you are not seeing any changes, check all the other stuff that can affect weight loss (like insulin resistance, sleep apnea, thyroid problems etc), and start tracking your food.

It's so easy to get too many calories with fats, oil, nuts and seeds etc.