Tirz 冷冻/解冻

[randompersonrandom]

I'm really strongly considering @indolent 's recon-a-kit-and-freeze method. I'm down to my last 75 mg of compounded (frozen), and then I start on my mostly-gyc stashes. A kit of 30 mg would 37 weeks, and I don't know that I'd love the idea of ten punctures in a 30 ml bottle of bac over that amount of time. But if I recon it all and filter into five cartridges of 60 mg each (2.73 ml each), purge the air, and into the freezer, that should be enough wiggle room to keep the freezing from popping the cartridge bottom out. And I've frozen carts before and never had a blowout.

 

[gothsoup]

I'm new here so excuse the silly question, but after reading this entire thread I'm not sure I have an answer to it. I have a tirz kit and BAC water. They're supposed to last me for 30 weeks. Is it okay to reconstitute then freeze, and thaw the reconstituted vials as I need them? I'm a bit confused and overwhelmed

 

[Grogu]

I'm new here so excuse the silly question, but after reading this entire thread I'm not sure I have an answer to it. I have a tirz kit and BAC water. They're supposed to last me for 30 weeks. Is it okay to reconstitute then freeze, and thaw the reconstituted vials as I need them? I'm a bit confused and overwhelmed

The overwhelming sentiment in this thread is that many people have had success reconstituting tirzepatide and then freezing and thawing those vials as needed. The general thought is that tirzepatide is a robust peptide. What part is causing you confusion?

 

[CNCCurrency]

The overwhelming sentiment in this thread is that many people have had success reconstituting tirzepatide and then freezing and thawing those vials as needed. The general thought is that tirzepatide is a robust peptide. What part is causing you confusion?

Agreed, I believe someone stated early in this thread that tirz is the cockroach of peptides

 

[skeptick]

I'm new here so excuse the silly question, but after reading this entire thread I'm not sure I have an answer to it. I have a tirz kit and BAC water. They're supposed to last me for 30 weeks. Is it okay to reconstitute then freeze, and thaw the reconstituted vials as I need them? I'm a bit confused and overwhelmed

I'm new here so excuse the silly question, but after reading this entire thread I'm not sure I have an answer to it. I have a tirz kit and BAC water. They're supposed to last me for 30 weeks. Is it okay to reconstitute then freeze, and thaw the reconstituted vials as I need them? I'm a bit confused and overwhelmed

Hey Goth, How have you determined how much Tirz you have and how is it to last you 30 weeks? I agree with these others that there are a number of folks on this board who speak of recon/transfer to vials/freeze till needed...

 

[indolent]

I'm new here so excuse the silly question, but after reading this entire thread I'm not sure I have an answer to it. I have a tirz kit and BAC water. They're supposed to last me for 30 weeks. Is it okay to reconstitute then freeze, and thaw the reconstituted vials as I need them? I'm a bit confused and overwhelmed .

I wouldn't repeatedly thaw/refreeze any one particular reconstituted vial, if that's what you're asking. Thaw, then refrigerate, the active-use reconned vial.

 

[gothsoup]

I wouldn't repeatedly thaw/refreeze any one particular reconstituted vial, if that's what you're asking. Thaw, then refrigerate, the active-use reconned vial.

The idea is to reconstitute all vials, then freeze, and only thaw once when it's time to use a vial.

 

[designing677]

I reconstitute a tirzepatide kit in one go, and move each vial to the fridge for its 4-6 weeks of active use.

I don't transfer to empty vials because I don't trust their sterility, and don't want to invest in lab-grade equipment to properly sterilize them. My pressure-cooker is for proteins.

What do you find is the advantage of doing it this way, rather than reconstituting a vial at a time, immediately prior to use?

 

[thatkatmat]

我取了一瓶60毫克（实际69毫克）的Tirz，用Hospira Bac溶解后分装成3瓶冷冻保存。过几天我会取出一瓶试试，周末前再汇报结果。我

反复阅读了关于Tirz稳定性的资料，感觉应该没问题。我还看到有文章说cagrinlintide的耐受性比Tirz更好。Reta可能对稳定性要求更高一些，但如果处理得当，应该不会有太大的降解。

 

[indolent]

您认为这种方法的优势是什么，而不是在使用前一次配制一小瓶？

时间上的便利；减少30毫升开封后药瓶的浪费。

正是出于消费者便利性的考虑，制药公司才能从缓释片中赚取数万亿美元，才能从每周注射而非每日注射的GLP-1制剂中赚取数万亿美元，才能开发每月注射一次的GLP-1制剂。

 

[designing677]

时间上的便利；减少30毫升开封后药瓶的浪费。

正是出于消费者便利性的考虑，制药公司才能从缓释片中赚取数万亿美元，才能从每周注射而非每日注射的GLP-1制剂中赚取数万亿美元，才能开发每月注射一次的GLP-1制剂。

谢谢。信息很有用。

 

[Ruckus4519]

我取了一瓶60毫克（实际69毫克）的Tirz，用Hospira Bac溶解液复溶后分成3瓶冷冻保存。过几天我会取出一瓶试试，周末前再汇报结果。

说实话，这确实是我的计划，这样我就不用多次下单，也能节省冰箱（公用冰箱）的空间等等。

不过我一开始只服用 2.5 毫克，所以不管怎样，我也不知道这算不算个好主意。

 

[randompersonrandom]

唉。我有一些T-30，总共装了34毫克（3盒）。如果我喜欢22毫克/毫升的浓度（我的确喜欢），那么如果我用1.54毫升的细菌水重新溶解每盒，那么一次溶解19盒的话，我就可以一次性用掉一整瓶细菌水。除以8毫克，那就是80周的冷冻TIRZ，而且用来溶解它们的细菌水是在瓶子第一次被刺破的当天使用并冷冻的。我可以随时取出一盒，解冻，过滤后装进烟弹里，这样就能用4周多一点。

所以，如果我真的相信 tirz 冷冻一年半左右都没问题，那这确实是个明智的选择，因为它很方便（装购物车可以节省 20-30 分钟，因为我已经一次性完成了复原和等待溶解的部分），而且 bac 在放入冰箱前几乎没有时间就被刺破了，唯一的缺点就是它对我的囤积癖大脑造成了心理打击（显然复原后的 tirz 的保存方式有所不同），以及迷信地担心把 tirz 放在冰箱里这么久会“变质”。

 

[randompersonrandom]

ok sorry for the double post, but OH! I use 12 ml for a klow cycle. That leaves me with 18 ml instead of 30, which means 11 vials, which is 46 weeks, and that feels less dramatic. So if I make sure that if I'm doing tirz, I do it when I do a klow cycle, then that one-shots the bottle with less...extremes of volume.

 

[thatkatmat]

I took a 60mg (actual 69mg) vial of Tirz, reconstituted it with Hospira Bac and split it into 3 vials and froze it. I'll pull one in a couple days and give it a go before this weekend and report back.

I'm fairly certain it will be fine after reading over and over again how robust it is. I've read that cagrinlintide will tolerate it even better than Tirz. Reta might be a little more fussy but if handled correctly should be good without much degradation.

So, I did it, I took my 69mg vial, split it into 3, 23.3mg vials and froze them. I took the 1st vial out of the freezer and stuck it in the fridge on thursday morning, it was thawed out and crystal clear on friday morning and I pinned it. I have tinnitus (a condition that causes ringing in my ears, Tirz makes it louder (so I can tell if the Tirz is working) Sure enough the ringing started getting louder and today I have sulphur burps which is another tell, lol. My appetite is gone as well.

i just made sure I was using sterile techniques, gloves and a mask and used all fresh needles when reconstituting and aliquoting...Sprayed down my working area and everything I was using with alcohol first.

Going to try it with my Cagri which is supposed to be the most durable of the Peps that I have, and eventually with my Reta and Survo stock when I start them. they say Reta is a little trickier but that it still works, you just aliquot less amounts and do like 2-3 weeks worth at a time to keep efficacy high.

Anyways, I'm not sure why people have been telling folks not to do it...It clearly works and I feel zero difference, if anything my symptoms feel stronger (maybe the vial had a little more fill). So, I say buy the big vials of Tirz at the discounted prices and aliquot!

 

[Ruckus4519]

@thatkatmat btw how many ml was per vial. did it expand by a lot when you froze them? how did you store them in the freezer? was sterility a point of concern for you?

 

[thatkatmat]

@thatkatmat btw how many ml was per vial. did it expand by a lot when you froze them? how did you store them in the freezer? was sterility a point of concern for you?

1mL per vial, actually ended up being 1.08mL per vial as the mass of the 69mg added about .25mL to the total. I put them in sterile 3ml vials using individual syringes for each vial, wore a mask, used gloves and wiped my work area with alcohol first. I don't have a hood so certainly not 100% sterile but I did my best. I placed them in a peptide storage box in the freezer rightside up and that was that. No expansion that I could see, no issues with the vials or rubber when thawed. Yes, sterility was a big concern for me, but I mitigated where i could. I had no issues with the injection site and today, almost a week after the day i thawed it, the 1st vial is still clear and looks good. I will pin again Thursday.

***I should add that this was just a test for my curiosity and i don't suggest anyone do it. I stated in my last post that " I say buy the big vials of Tirz at the discounted prices and aliquot!" that was irresponsible..., I shouldn't have said that but it won't let me edit it out. What I should have said was that "I should have bought bigger vials at discounted prices"

-Cheers

 

[Ruckus4519]

1mL per vial, actually ended up being 1.08mL per vial as the mass of the 69mg added about .25mL to the total. I put them in sterile 3ml vials using individual syringes for each vial, wore a mask, used gloves and wiped my work area with alcohol first. I don't have a hood so certainly not 100% sterile but I did my best. I placed them in a peptide storage box in the freezer rightside up and that was that. No expansion that I could see, no issues with the vials or rubber when thawed. Yes, sterility was a big concern for me, but I mitigated where i could. I had no issues with the injection site and today, almost a week after the day i thawed it, the 1st vial is still clear and looks good. I will pin again Thursday.

***I should add that this was just a test for my curiosity and i don't suggest anyone do it. I stated in my last post that " I say buy the big vials of Tirz at the discounted prices and aliquot!" that was irresponsible..., I shouldn't have said that but it won't let me edit it out. What I should have said was that "I should have bought bigger vials at discounted prices"

-Cheers

Thank you for sharing. I am still considering my options, and I’m torn between being economical and making my experience as easy as possible

You don’t use pens? Where did you get your vials? Are they that K Tek brand from AE, or did you procure them from elsewhere

 

[thatkatmat]

Thank you for sharing. I am still considering my options, and I’m torn between being economical and making my experience as easy as possible

You don’t use pens? Where did you get your vials? Are they that K Tek brand from AE, or did you procure them from elsewhere

Well, I have pens but don't use them, I don't do daily peps so, I'm good. I bought my vials from Peptide critc and Underground Sup. and a few others...Not Amazon. I did my best to find sterile vials.

 

[Lyophilized]

Can you point me to this study..I might try to do the test myself but if i had Jano's word that they tried it and the Tirz wasn't broken, I'd be more apt to try it myself.