我看了那个视频，真是让我大开眼界！我指的是先把药水冲泡好，然后冷冻起来以后再用。我读到的大部分资料都说不要这么做。但是在这个论坛上，似乎有一些研究结果却恰恰相反。Airborne Daddy said:
Tirz 冷冻/解冻
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他们以为你指的是未解冻的液体。没人会建议你把液体冷冻起来。thatkatmat said:
I will, under certain circumstances.Airborne Daddy said:
May I ask, which sort of circumstances?zpped said:
A member in a similar thread said they're going to try it and report back, but ended up not reporting back. I joined peppy's but I it looks like it could be a while until I gain access to that info...
I guess the only thing I would lose is a little product and a day or 2 of being hungry if it doesn't work...I mean, before GLP1's I was hungry for the better part of 50 years...lol
Cheers and thanks again!
Tirz is apparently a robust peptide. If I was freezing liquid I would want the bottle to be fresh vs closer to the discard date. I’d want fresher BAC. I’d freeze it once and thaw it once, if I had a 120mg vial I might would portion it out into more useful vial sizes so I could thaw what I needed.
I’d be more inclined to store in a vacuum based thermos to give time if the power went out… if you want to get more aggressive, put the thermos in a quality cooler and fill the cooler with thermal mass, in a deep freezer (-40°). Think the thermos in a yeti cooler full of frozen water.
You could put tattle tales in to track if/when the temp got above the freezing point.
Then again, it’s just Tirz, freezer space with a bunch of extra layers could cost more.
I’d be more inclined to store in a vacuum based thermos to give time if the power went out… if you want to get more aggressive, put the thermos in a quality cooler and fill the cooler with thermal mass, in a deep freezer (-40°). Think the thermos in a yeti cooler full of frozen water.
You could put tattle tales in to track if/when the temp got above the freezing point.
Then again, it’s just Tirz, freezer space with a bunch of extra layers could cost more.
woundcarping's first paragraph sums up my thoughts. I wouldn't bother with the second.thatkatmat said:
I'd also freeze reta the same way if I needed to.
Awesome, Good to know, I'm gonna research it myself now...BTW, with your help i was able to get on peppy's and find some very interesting and corroborating information. As well as some info on Cagri that had been looking for..Thanks again!zpped said:
Elaborate perhaps? What reconstituted peptides do you freeze?indolent said:
I mean, I've been freezing my Reta and Tirz since I've been buying huge bottles. Divvying into smaller bottles, freezing And thawing those for myself and other rats, they seem to work fine??Airborne Daddy said:
I reconstitute a tirzepatide kit in one go, and move each vial to the fridge for its 4-6 weeks of active use.Airborne Daddy said:
I don't transfer to empty vials because I don't trust their sterility, and don't want to invest in lab-grade equipment to properly sterilize them. My pressure-cooker is for proteins.
so you did reconstitute and then freeze? I reconstituted a vial when I got them in the mail and I'm just now getting to the point of needing it (ran out of name brand). I had planned to test if it still works after freezing it since my compounding pharmacy suggested freezing theirs.Gr33dyOctopus said:
my previous message was actually for you, quoted the wrong personindolent said:
so you did reconstitute and then freeze? I reconstituted a vial when I got them in the mail and I'm just now getting to the point of needing it (ran out of name brand). I had planned to test if it still works after freezing it since my compounding pharmacy suggested freezing theirs.
For tirzepatide, freezing once, then refrigerating, hasn't been shown in laboratory studies to degrade the content mass, which basically means "works."john_askins said:
There are questions about sterility however, with some people saying that the benzyl alcohol in the bac water can separate out when frozen. I'm not aware of lab tests for sterility with freeze/thaw/refrigerate.
My assessment, for my own use, is that I'm not worried about that...each of us has to gauge comfort level with risks independently.
I've read that sterility would be the one thing you would worry about when freezing once and so perhaps try to use the thawed aliquot within 14-21 days, but, YMMV
That doesn't make any sense.thatkatmat said:
I've talked about this before, but when I first started in September of 2024 I purchased from a medispa/compounding pharmacy that sent me a vial of reconstituted Tirz that I was specifically instructed to "keep frozen", thaw on my counter once a week for drawing a dose, and then put it back in the freezer. It was a three month supply (side note, paid $3000 for it) and it worked so well that I knew I had to come up with a way to afford this medication forever and the rest is history.
I meant to say stability, not sterility. Post thaw stability could decrease slightly.zpped said:
What does stability mean in this context?thatkatmat said:
If = degradation, that's been tested for tirz and the decrease in mass is negligible, even after two (three?) freeze/thaw cycles.
I was in fact referring to degradation, as I understand it , it's not because it suddenly “goes bad.” but rather, the freeze thaw cycle could introduce a tiny structural stress event
That possible stress reduces confidence slightly to where you might want to use conservative buffers. Maybe try to use it in 3 weeks rather than the standard 4... But I did also say "YMMV". I mean, some people use refrigerated peptides for months.
That possible stress reduces confidence slightly to where you might want to use conservative buffers. Maybe try to use it in 3 weeks rather than the standard 4... But I did also say "YMMV". I mean, some people use refrigerated peptides for months.
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