Tirz experience = Reta experience?

[spanky2026]

Just curious about something I keep reading that I assume is anecdotal, have no idea how real it is among users:

I often see people saying I had zero side effects on (insert Tirz or Reta) and when I added in or changed to (the other) I also had zero side effects. Yes, of course, we're all different etc, but I'm curious if zero ill effects on one is at least a semi-reliable indicator of how you may react to the other?

 

[woundcarping]

I have low/no sides on Tirz/Reta.... but Sema hits different.

I'd think you're peachy on Reta, going to Tirz should be drama free. The other way around can be a bumpy ride, depending on how you respond and how you handle the bridge.

 

[spanky2026]

I have low/no sides on Tirz/Reta.... but Sema hits different.

I'd think you're peachy on Reta, going to Tirz should be drama free. The other way around can be a bumpy ride, depending on how you respond and how you handle the bridge.

Sema definitely has a more serious side effect profile, it's why so many don't even consider it.

 

[woundcarping]

Sema definitely has a more serious side effect profile, it's why so many don't even consider it.

Being on 18-20mg of Reta, I didn't expect .25mg of Sema to be so profound. I still "like it" but since I have "plenty of everything" I may switch to Tirz or an Amylin agonist after I adjust my Reta dosage a bit between my first goal weight and second. Going to see if I get easier sleep quantity and let my RHR calm down a bit.

SW 282lb, GW1 200lb, GW2 ~180lb, current weight 200lb, 34 weeks in. I still want to drop this last 20lb with purpose, going to see if I can let off the gas a bit and cruise while roughly maintaining my 1% w/w loss rate.

 

[Speedy 24430]

Only been on brand name, Tirz and Reta. Different side effects from Reta and Tirz. Tirz sides obviously same as brand name M.

Could not tolerate Reta. Low bp normally now and Reta drove it down even further making me feel like crap.

Anyhoo. Looking for the supposedly hilarious ghk-cu topic if anyone wants to shoot me a link.

Also since I lurk trying to see if after a few years I graduated from being a newbie here.

—still a newbie

 

[Oldguy]

Go ahead crack open that Reta that you have been hiding in the freezer.

 

[spanky2026]

Go ahead crack open that Reta that you have been hiding in the freezer.

Oh, I will eventually, in no hurry, in the meantime been reading and it's all over the place, some moving smoothly from one to the other, others getting laid out by the change, so I really am interested in people here's experiences, but hardly anyone has chimed in. Back to more reading.

 

[Oldguy]

It’s a much different crowd here than it was 6 months ago

 

[lessthanhalf]

From both my experience and reading a lot about how they interact with the different receptors, reta and tirz are quite similar in terms of side effects, the main difference being reta increases sympathetic nervous system activity more causing increased heart rate, and sometimes insomnia or other effects. Reta also has weaker GIP agonism than tirz, so has worse gastrointestinal side effects than tirz, as GIP counteracts the negative side effects from GLP-1 agonism, but not a huge difference. Reta also seems to cause more dysasthesia/ skin sensory side effects than either sema or tirz, never seen any good explanation for why this happens more with reta than the others.

Sema has significantly higher rates of gastrointestinal side effects than reta or tirz, due to the lack of GIP agonism. Also more likely to cause food aversion and malaise, though not as common, can cause skin sensory issues but weirdly only at very high doses.

I had horrible nausea, malaise and food aversion from quite low doses ( 0.8mg/w ) of doctor prescribed sema, for a year, before I discovered grey peptides, but almost none from 15mg of tirz and hardly any from 5mg of reta added to that. This was a much much bigger difference than I was expecting.

In general they are acting on receptors in similar ways, the GI effects are from glp-1, gip seems to be mostly positive reducing glp-1 side effects, and glucagon agonism causes the increased heart rate, so it is possible to get a good idea of how you will respond to tirz from taking reta and vice versa, but some reactions to glp drugs are idiosyncratic and individual, so there are no guarantees.

Overall tirz has the lowest side effects followed not that far off by reta, with sema coming last by a fair margin.

 

[Builderman]

I took 2.5MG trizepatide for a month about a year ago. This was before I had done any real research and truthfully was still eating horribly, not drinking enough water, and just not really knowing what I was doing. It gave me the most insane heartburn I have ever had, nothing made it go away and it even lasted a couple more weeks once I stopped taking the tirz. I’m nearly certain that was from the poor diet and not being hydrated enough while taking it.

Fast forward to this year and I started taking Reta, I had no bad effects until I got impatient and titrated up way too fast to 7mg. I got pretty unpleasant dysesthsia that lasted for a few weeks. I’m still at the 7mg and 3 weeks ago added 2.5 mg of tirz to help with some appetite suppression, which has worked great.

Aside from the dysesthesia, which is gone now, I’ve had no real negative effects from the Reta or tirz this time around. I’ve even lost 45 pounds which I’m ecstatic about.

 

[Flash-BCR]

I was at 5mg x2 times a week on tirz Friday and Monday...I pinned 2mg of reta (1mg Friday night -1mg Saturday morning after I woke up not dead ) and after not experiencing a lot of symptoms from the reta decided to be cute and pinned 6mg of the tirz on Monday....hell, you would have thought I pinned 10mg the way the GI symptoms came on...I was worried about the reta, and the tirz is what bit me....But I will inch up on the reta to 4mg as soon as possible, but always being wary that reta has a fiercer bite than tirz...

 

[unclebuff702]

I have low/no sides on Tirz/Reta.... but Sema hits different.

I'd think you're peachy on Reta, going to Tirz should be drama free. The other way around can be a bumpy ride, depending on how you respond and how you handle the bridge.

Same.

I thought I was going to die on Sema. Turns out, the doctor (actual MD, not a health spa lol) I got the RX from started me at 2.4mg. Two years later when I started researching other options I found out that apparently the doctor a) wanted me to die, b) was super ignorant or negligent, or 3) thought I was fat enough to warrant going straight to the end zone lol.

So, I could be biased thinking sema hit different, but I've had almost zero sides on Tirz or Reta, and I'd rather stick a fork in an electric socket than feel the way I felt on my very first dose Sema.

 

[AngieHolmes 53745]

Only been on brand name, Tirz and Reta. Different side effects from Reta and Tirz. Tirz sides obviously same as brand name M.

Could not tolerate Reta. Low bp normally now and Reta drove it down even further making me feel like crap.

Anyhoo. Looking for the supposedly hilarious ghk-cu topic if anyone wants to shoot me a link.

Also since I lurk trying to see if after a few years I graduated from being a newbie here.

—still a newbie

There is no "brand name" Reta yet . . .

 

[woundcarping]

Same.

I thought I was going to die on Sema. Turns out, the doctor (actual MD, not a health spa lol) I got the RX from started me at 2.4mg. Two years later when I started researching other options I found out that apparently the doctor a) wanted me to die, b) was super ignorant or negligent, or 3) thought I was fat enough to warrant going straight to the end zone lol.

So, I could be biased thinking sema hit different, but I've had almost zero sides on Tirz or Reta, and I'd rather stick a fork in an electric socket than feel the way I felt on my very first dose Sema.

Wow, I feel like our experiences were wildly different!

I had the “worst sides” when starting Sema relative to my very minimal sides with Reta or Tirz. Malaise, stomach uneasiness, overly suppressed appetite. Going from .25mg first dose to .125mg subsequent split doses mostly fixed that.

2,4mg starting out must have been a wild ride. What happened to your weight during that experience?

 

[spanky2026]

Same.

I thought I was going to die on Sema. Turns out, the doctor (actual MD, not a health spa lol) I got the RX from started me at 2.4mg. Two years later when I started researching other options I found out that apparently the doctor a) wanted me to die, b) was super ignorant or negligent, or 3) thought I was fat enough to warrant going straight to the end zone lol.

So, I could be biased thinking sema hit different, but I've had almost zero sides on Tirz or Reta, and I'd rather stick a fork in an electric socket than feel the way I felt on my very first dose Sema.

Please tell me you got a new doc?

 

[reta-stacker]

It’s a much different crowd here than it was 6 months ago

In a good or a bad way?

 

[chewonmysac]

In a good or a bad way?

Short-term bad but good long-term. After the constant threat of compounding GLP becoming extinct, Reddit users started to flood the site looking for alternatives. Human nature, including myself, in the fall of 2025. Noobs started creating new posts in the 1st week they joined, asking the same ridiculous questions they were asking on Reddit. Eventually, I expect people to adapt to this type of forum or just go back to Reddit and join back into the general population on the same level as incarceration. I can always tell when a new poster is getting ready to nuke themselves. Sometimes it is better not to respond, keep your eyes forward, soak up as much data as possible, and run an aggregate.

 

[woundcarping]

…soak up as much data as possible, and run an aggregate.

That moved something in me.

 

[deleted.user.25]

Just curious about something I keep reading that I assume is anecdotal, have no idea how real it is among users:

I often see people saying I had zero side effects on (insert Tirz or Reta) and when I added in or changed to (the other) I also had zero side effects. Yes, of course, we're all different etc, but I'm curious if zero ill effects on one is at least a semi-reliable indicator of how you may react to the other?

I found that on Tirz i had Zero side effect, on Reta which i added to the mix on Friday I felt a bit drained yesterday and today I am feeling Great. I know it's still early but with my body I'm a sure thing. If it didn't hit harder today the worst is over. I will be doing my mix for these last 27lbs to hit my goal of 145lbs with two days on two days off of each.

 

[deleted.user.25]

I took 2.5MG trizepatide for a month about a year ago. This was before I had done any real research and truthfully was still eating horribly, not drinking enough water, and just not really knowing what I was doing. It gave me the most insane heartburn I have ever had, nothing made it go away and it even lasted a couple more weeks once I stopped taking the tirz. I’m nearly certain that was from the poor diet and not being hydrated enough while taking it.

Fast forward to this year and I started taking Reta, I had no bad effects until I got impatient and titrated up way too fast to 7mg. I got pretty unpleasant dysesthsia that lasted for a few weeks. I’m still at the 7mg and 3 weeks ago added 2.5 mg of tirz to help with some appetite suppression, which has worked great.

Aside from the dysesthesia, which is gone now, I’ve had no real negative effects from the Reta or tirz this time around. I’ve even lost 45 pounds which I’m ecstatic about.

Congrats that's a Win,. Good for you