替泽帕肽的可能性？？？？？

[therealdlg]

Well gosh, if we're posting charts, mine had Tirz for the first ~month before switching to Reta since I thought it better fit my goals.

I've averaged .35lb/day lost according to this linear regression.

View attachment 26322

W/W%

View attachment 26323

What were the differences between Tirz and reta for you?

 

[woundcarping]

What were the differences between Tirz and reta for you?

I was on Tirz for less than a month, and it was my first month… I don’t reckon I have any useful anecdotes from that.

 

[Gr33dyOctopus]

F68. Started GLP1s on June 6, 2025. So in one year: starting weight 393 pounds. Today, weight is 323 pounds. So for me: female, hormone issues, 68 years old, AFib, Gout, CKD, Venous Insufficiency, degenerative spine, losing 70 pounds in one year on mostly Tirzepatide without a single bit of calorie-counting or increased exercise is a miracle. So, a 17.8% Loss for me in one year . And trust me, the loss was the furthest thing from linear. (see image)

For YOU, as a man without these issues, I would expect you to lose at least 100 pounds over a year.

View attachment 26321

Yes, I lost 115 from august25 to may26, gained a little back have had to go off and on for surgery, dr stuff but thats a huge % of bodyweight for me in... 9 months?

 

[Sasquatch]

What were the differences between Tirz and reta for you?

Brother Grogu sum'd it up as well if not better than I could.

But here we go, reta was not working for me, personally. Did I try it for long enough? Did I try different vendors in case of potency issues? This is why the decision is your's personally.

 

[lessthanhalf]

Such inspiring stories! I guess my worry is the difference in appetite suppression between Tirzepatide and Reta...Ive heard its not that powerful with reta..Is that true?

I find this question interesting and I see it all the time, that so many people on this forum say reta suppresses appetite or reduces food noise less than tirz, but all the studies show it causes more weight loss. I do not think the difference in appetite reduction in practice is really that huge.

Assuming the glucagon agonism boosts metabolic rate or energy expenditure 100kcal/day more than tirz, so is about 36500 kcal over a year, divided by 7700 kcal/kg of fat lost is about 5 kilos a year ( simplified a bit ) . weight loss from reta is about exactly that much more in a year , 29% vs 24/25%, assuming you are 100kg to start and 30% or more overweight. So in theory if they suppress appetite the same amount then it works out perfectly, but it is possible reta causes 200 kcal/day more energy expenditure , so it could still cause more weight loss, with less appetite reduction and higher calorie intake, but only if it increases calories used per day by more than 100 kcal.

 

[NagChamp]

Lay off SOS. SOS= Salt, oil and sugar.

Don't eat the holy trinity of deliciousness?!

 

[reta-stacker]

Good luck on your quest.

I only started GLPs after losing most of the weight from 145kg to 75kg, but have found they make keeping the weight off much easier, and of course every previous weight loss attempt had ended with me regaining the weight but 3 1/2 years later this time still normal BMI.

I think this is where GLP drugs shine, maintenance, as making a mammoth effort with diet and exercise to lose weight is hard but not as hard as keeping it off it. But losing it with GLP drugs and then staying on them basically keeps the weight off long term, not even surgery is that good in terms of long term maintenance, although it can cause even larger weight losses. The fact that keeping the weight of long term is actually realistic is a good motivator, especially if you have previously lost weight and regained it.

There really is a lot of individual variation in responses to GLP drugs, a small percentage maybe 5-10% do not lose much weight, and some lose lots even on tiny doses, and some get intolerable side effects. You really just have to start and slowly build up doses to find out how well they work for you, and hope for the best. For the vast majority these drugs are a game changer for obesity.

On average tirz causes 25ish% weight loss in a year or so and reta 29%, so reta is a bit more effective, but probably has slightly higher rates of side effects. Given you want to lose a lot of weight, reta might be the better choice, but tirz is fairly close behind in effectiveness.

I can relate to the exercise issue. Intense exercise can be profoundly aversive to someone who is unfit, basically making you feel so horrible it becomes very difficult to force yourself to keep doing it. The most effective way to start and keep going is to make it easy not hard. When I was still overweight and profoundly unfit, I just decided I had to go for a 5 minute walk every day, basically making it so easy there was no reason to avoid doing it, and almost no chance of it making me feel exhausted or ill afterwards, and I gradually built up the time over several months and turned it into a habit and eventually got to 3 hours or so a day after several months and quite a few kilos lighter which helped a lot, without the kind of aversive post exercise fatigue that I had typically had when attempting exercise. It does not matter what exercise it is , but the general concept is to lower the barrier to doing it so low that it is super easy to do and you are less likely to avoid it and have a decent chance of turning it into a long term habit. But you have to do that minimal bit every day or a certain number of times per week. I did not even try to start walking until I got to 115kg as even then my feet hurt like hell just from walking 5 minutes, sometimes it is reasonable to wait before starting up exercise if severely obese.

Eating a good diet on GLP drugs is a good idea, but they work anyway even if you don't just by making you less hungry so you eat less, they probably work better if they are not fighting against a high fat high sugar diet, but they tend to encourage you to improve diet quality anyway. Eating at least 1.5grams per kilogram of body weight of protein is a good idea to minimise loss of muscle mass while losing weight. And high protein intake is more filling per calorie than any other food which helps with hunger and weight loss.

Good post. This is a great recipe for anyone who struggles with lifestyle changes involving exerices and dietary change. Make it easy so you don't hate it, and actually allow yourself to accomplish a daily, or at least regular, goals. And on the food side, avoid sugary, fatty and highly processed foods. GLPs generally make that much less of a challenge. For me, reta made that easy.

 

[reta-stacker]

I can't comment comparatively bcuz I've never taken tirz, but in my own experience with reta, food noise virtually disappeared at even entry level doses. I've only been doing reta for three months, but I've lost 30 lbs - and that's at a low dosage of 2 to 2.5 mg every 3 or 4 days. It takes virtually no discipline to avoid my once-beloved Reese's Peanut Butter Cups and similar bars from the gods. I can walk through the snack bar aisles of grocery aisles with ease and without pause. I was already in the habit of resistance training three times a week so I didn't need to add an exercise regimen to my life, but I do find my workouts are better, perhaps less to do with the peptide and more to do with increased energy from my weight loss. I also believe that bcuz reta's weight loss comes from fat, muscle and bone, resistance training to protect muscle mass is important. Anyway... best of luck on your journey to a new you.

 

[Stace_wow]

Soooo....For some background info: I am a 42 y/o Male, 6'2" and weigh 370 pounds. Over the span of 1 year on tirzepatide, what is a realistic estimate of how much weight I could lose? Currently I am pretty sedentary with a desk job, but I actually love to work out, so that wont be a problem. And I am in the middle of planning a realistic diet i can stick with. My big problem in the past has been going hard core with the workouts and cardio to the point where it is just not sustainable and then I give up. Help please

我发现最实际的饮食方案是增加食物摄入，而不是减少食物摄入。也就是说，用蛋白质、蔬菜或水果代替我平时吃的薯片之类的零食。在每日卡路里摄入范围内，我可以随意选择想吃的食物，并且我会记录下来。我会保持热量缺口，同时也会计划一些我喜欢的、可以重复食用的餐食（因为我也是上班族），这样可以尽可能地简化我的饮食。

此外，我的运动目标是在不增加饥饿感的情况下提高每日总能量消耗（TDEE），所以我主要增加了一些低强度有氧运动（LISS），比如增加步行。我每天午休时间都会散步，并且会设定一些切实可行的目标，比如午饭后步行10分钟，并且每天都会完成这个目标。

我使用Tirz的目标是健康……当然，这包括减肥，但这并不是我唯一想要改善的指标。由于家族有心脏病史，我对自己的心血管系统功能非常关注……自从开始Tirze训练以来，我的整体健康状况有了显著改善。但我今年3月27日开始时体脂率高达43%，属于病态肥胖，目前只减掉了大约20磅（约9公斤）。每个月我都在不断调整，非常期待自己能坚持到什么程度。

你一定可以的，有了像这样的社群的支持，你一定会做得非常好。祝你好运！

 

[Hawk_recon]

我发现最实际的饮食方案是增加食物摄入，而不是减少食物摄入。也就是说，用蛋白质、蔬菜或水果代替我平时吃的薯片之类的零食。在每日卡路里摄入范围内，我可以随意选择想吃的食物，并且我会记录下来。我会保持热量缺口，同时也会计划一些我喜欢的、可以重复食用的餐食（因为我也是上班族），这样可以尽可能地简化我的饮食。

此外，我的运动目标是在不增加饥饿感的情况下提高每日总能量消耗（TDEE），所以我主要增加了一些低强度有氧运动（LISS），比如增加步行。我每天午休时间都会散步，并且会设定一些切实可行的目标，比如午饭后步行10分钟，并且每天都会完成这个目标。

我使用Tirz的目标是健康……当然，这包括减肥，但这并不是我唯一想要改善的指标。由于家族有心脏病史，我对自己的心血管系统功能非常关注……自从开始Tirze训练以来，我的整体健康状况有了显著改善。但我今年3月27日开始时体脂率高达43%，属于病态肥胖，目前只减掉了大约20磅（约9公斤）。每个月我都在不断调整，非常期待自己能坚持到什么程度。

你一定可以的，有了像这样的社群的支持，你一定会做得非常好。祝你好运！

嘿，你“只减了20磅”依然很棒！继续加油

 

[Stace_wow]

嘿，你“只减了20磅”依然很棒！继续加油

谢谢你！

 

[Skidude]

使用TIRZ减肥法，我每周大约减掉2磅。我原本打算达到185磅的目标体重，但后来决定以163磅的正常BMI为目标。

我看到一些关于RETA减肥法的担忧，比如可能存在心率问题，所以如果你选择RETA，需要注意心率。不过，RETA在试验中总体减重百分比方面表现更好。TIRZ减肥法

对我来说效果很好，7个月内体重变化幅度控制在正负25%以内。

 

[FLglpguy]

我年纪比你大很多，而且一开始比你重一些，但到目前为止，Tirz 对我来说效果非常棒！我身高6英尺2英寸（约1.88米），55岁，体重386磅（约173公斤）。我从5月7日开始服用Triz，剂量从0.25毫克/毫升增加到0.5毫克/毫升。短短5周，我就减掉了26磅（约12公斤）。

我一次都没锻炼过，整天在家办公，坐在办公桌前。我彻底改变了饮食习惯，而且非常容易做到。我现在不再想吃油炸食品，家里也没有任何零食或不健康的食物。

我只吃沙拉、生蔬菜、番茄罗勒汤、蘑菇骨汤、豌豆汤、用杏仁奶做的鲜果冰沙或新鲜水果，几乎不吃肉。有几个星期天，我吃了一小块肉——2-3个小火鸡肉丸和几条去皮鸡胸肉。除此之外，我只吃上面提到的食物，以及无盐坚果和高蛋白/高纤维能量棒。

我还补充了维生素B12 。 早上服用2000微克镁，晚上服用225毫克苹果酸镁以改善睡眠，午餐服用20克胶原蛋白以保护关节和皮肤，傍晚服用酪蛋白以便在休息和睡眠时缓慢释放蛋白质。开始锻炼后，我会添加乳清蛋白作为锻炼前补充剂。我很快就会开始力量训练，这样减重后就不会出现大量皮肤松弛。目标体重是215磅。

 

[Hawk_recon]

我年纪比你大很多，而且一开始比你重一些，但到目前为止，Tirz 对我来说效果非常棒！我身高6英尺2英寸（约1.88米），55岁，体重386磅（约173公斤）。我从5月7日开始服用Triz，剂量从0.25毫克/毫升增加到0.5毫克/毫升。短短5周，我就减掉了26磅（约12公斤）。

我一次都没锻炼过，整天在家办公，坐在办公桌前。我彻底改变了饮食习惯，而且非常容易做到。我现在不再想吃油炸食品，家里也没有任何零食或不健康的食物。

我只吃沙拉、生蔬菜、番茄罗勒汤、蘑菇骨汤、豌豆汤、用杏仁奶做的鲜果冰沙或新鲜水果，几乎不吃肉。有几个星期天，我吃了一小块肉——2-3个小火鸡肉丸和几条去皮鸡胸肉。除此之外，我只吃上面提到的食物，以及无盐坚果和高蛋白/高纤维能量棒。

我还补充了维生素B12 。 早上服用2000微克镁，晚上服用225毫克苹果酸镁以改善睡眠，午餐服用20克胶原蛋白以保护关节和皮肤，傍晚服用酪蛋白以便在休息和睡眠时缓慢释放蛋白质。开始锻炼后，我会添加乳清蛋白作为锻炼前补充剂。我很快就会开始力量训练，这样减重后就不会出现大量皮肤松弛。目标体重是215磅。

既然你提到了蛋白质作为锻炼前补充剂，我就补充一点：一天中摄入蛋白质的时间其实并不重要，重要的是总量。最近的研究已经证实了这一点。如果你需要蛋白质来避免锻炼时感到饥饿，那另当别论，但就对肌肉的影响等方面而言，摄入时间并不重要。