I just swapped about 6 weeks ago from 10mg Tirz to titrating up Reta. Weight loss stalled out during the swap, but is picking up again.
The appetite changes are kinda a mixed bag. I honestly kinda miss the rarely-hungry feeling of the Tirz, and being able to eat a small breakfast and then go for a 10 mile hike without having to carry food.
BUT...I have so much more energy on the Reta. Lifting and cardio both feel a lot stronger and more endurance.
So I may land on about 4mg/wk of reta and weave in a small amount of tirz to keep appetite down.