Looks very promising…. Have the vendors started vending Mazdutide?
There has been additional data released on the stage 2 trail of Mazdutide.
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Yes, I’ve seen it offered occasionally.KYRivianMan said:
Just did a quick look to see and currently 2 out of the 3 suppliers I have ordered from in the past has it for sale....AC Peptides and QSC
Currently AmoPure is not showing it on their website...
Not making any recommedations just thought I would have a quick look...so definitly available for research
Currently AmoPure is not showing it on their website...
Not making any recommedations just thought I would have a quick look...so definitly available for research
lol no kidding. What is this post??Dee X said:
Would love to see the info you are referring to!
There was a news release in late July where Innovent, who is the company conducting trials, announced the 2nd phase three trial of Maz in patients with type 2 diabetes and their plans to apply for a new drug application in China. The results seem pretty promising.
Just found this re: Mazdutide:
A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity - Nature Communications
Mazdutide is a once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. Here, the authors show mazdutide was well tolerated over 24 weeks and demonstrated significant and clinically meaningful body weight loss, compared with placebo, in Chinese overweight adults or adults...
www.nature.com
There’s tons of info starting to flow regarding this peptide.
Of course Eli Lilly is in bed with China on this one…so expect trouble down the road from two directions.
A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity - Nature Communications
Mazdutide is a once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. Here, the authors show mazdutide was well tolerated over 24 weeks and demonstrated significant and clinically meaningful body weight loss, compared with placebo, in Chinese overweight adults or adults...
www.nature.com
There’s tons of info starting to flow regarding this peptide.
Of course Eli Lilly is in bed with China on this one…so expect trouble down the road from two directions.
Drug looks interesting. Dual agonist but glucagon/glp instead of gip/glp
Mazdutide is an analog of oxyntomodulin (OXM),which is a natural hormone found in the human body, and modified to have a much longer half-life. From this paper:
Oxyntomodulin (OXM) is an endogenous dual agonist of the GCGR and GLP-1R, which increases energy expenditure and reduces food intake, leading to weight loss.[24] Moreover, administration of OXM in diet-induced insulin-resistant mice improved glucose tolerance, and this effect was also observed in T2DM patients.[25], [26] The clinical use of OXM was mainly limited by its extremely short half-life (∼10 min). Thus, several long-acting GLP-1R/GCGR dual agonists were developed, and some of them are currently tested in clinical, such as cotadutide, BI456906 and mazdutide (IBI362)
If you want the real information, look at what drug companies are telling their investors, not their customers.
https://img.innoventbio.com/Innovent_Clinical_Data_Update_of_Mazdutide_IBI362_2024_ADA_20240624_vf.pdf
Oxyntomodulin (OXM) is an endogenous dual agonist of the GCGR and GLP-1R, which increases energy expenditure and reduces food intake, leading to weight loss.[24] Moreover, administration of OXM in diet-induced insulin-resistant mice improved glucose tolerance, and this effect was also observed in T2DM patients.[25], [26] The clinical use of OXM was mainly limited by its extremely short half-life (∼10 min). Thus, several long-acting GLP-1R/GCGR dual agonists were developed, and some of them are currently tested in clinical, such as cotadutide, BI456906 and mazdutide (IBI362)
If you want the real information, look at what drug companies are telling their investors, not their customers.
https://img.innoventbio.com/Innovent_Clinical_Data_Update_of_Mazdutide_IBI362_2024_ADA_20240624_vf.pdf
The effects on liver fat, combined with comparable weight loss to Tirzepatide AND lower serious adverse effects than Tirz is impressive. I'd like to see how it compares to Retapeptideusername said:
Link isn't working, here it is:peptideusername said:
Mazdutide study
Very interesting. I'd like to know how it acts without the GIP agonism compared to Reta.
i've taken a couple vials of this. it jacked up my heart pretty good. i'm going to let it lie for a while. sema is working pretty good right now and I feel relaxed not jacked up.
That would be the glucagon action at play obviously. Reta does not do this to me, but I also take magnesium glycinate (500mg 2 at night), which helps my heart work much better- I no longer need to take blood pressure meds. I also have benign PVCs and I haven't had one heart flutter while on Reta.
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