The Holy Grail of weight loss?
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professorpeppy
GLP-1 Apprentice
seen some buzz about this on tiktok. sounds awesome and would make weight loss so much more accessible for folks who cant use needles etc
professorpeppy said:
If it ever comes to market, I’m thinking it will likely not be covered by insurance and will be cost prohibitive. Pills will probably be the best option for folks who don’t like needles. And probably part of a step therapy regime.
DrPEPr
GLP-1 Enthusiast
Seems promising.
I believe gene editing is the future, but it does sound a little scary.
I also see the trial kicks off in the Netherlands.
Too bad I don't qualify for participation
I believe gene editing is the future, but it does sound a little scary.
I also see the trial kicks off in the Netherlands.
Too bad I don't qualify for participation
lessthanhalf
GLP-1 Specialist
The idea of a permanent fix sounds good. I am not sure how it is going to work, I wonder if they have tried it in an animal model already?
Apart from the method of getting the gene therapy into the pancreas which has to have a few percent chance of causing pancreatitis, as pancreases get inflamed if you look at them let alone infuse anything into them.
And it has to be the real GLP-1, or something very similar , which has a very short half life, and to have effects anything like the drugs it would have to make a lot of it, as glp-1 agonists tend to be given at levels orders of magnitude higher than endogenous GLP-1, and you would not want to get too many copies of the gene working or you would get side effects that never go away.
And then there is the cost, the few gene therapies that are actually used cost millions.
Apart from the method of getting the gene therapy into the pancreas which has to have a few percent chance of causing pancreatitis, as pancreases get inflamed if you look at them let alone infuse anything into them.
And it has to be the real GLP-1, or something very similar , which has a very short half life, and to have effects anything like the drugs it would have to make a lot of it, as glp-1 agonists tend to be given at levels orders of magnitude higher than endogenous GLP-1, and you would not want to get too many copies of the gene working or you would get side effects that never go away.
And then there is the cost, the few gene therapies that are actually used cost millions.
Smiter
New member
I'm glad that somebody is trying gene therapy for GLp-1. For a long time, we have been dreaming about gene therapy countering myostatin. Just to whip some bullies... Bully whippet syndrome
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