Tesa + Tirz combo

[70707]

Been on 5mg Tirz since December '25 and looking to introduce a weekly 5mg tesa dose to preserve muscle and attack visceral fat. Trying to keep number of peps at a minimum, reduce unnecessary pinning and risk of side effects whilst sticking to the lowest effective dose.

Currently not training due to a fracture but hoping to hit the gym once I recover.

Anyone try this and how did that work out for you?

 

[derekd419]

Been on 5mg Tirz since December '25 and looking to introduce a weekly 5mg tesa dose to preserve muscle and attack visceral fat. Trying to keep number of peps at a minimum, reduce unnecessary pinning and risk of side effects whilst sticking to the lowest effective dose.

Currently not training due to a fracture but hoping to hit the gym once I recover.

Anyone try this and how did that work out for you?

I just started mine 1 week ago exactly, my blood sugar levels have been high since starting tesa, with it being the main culprit as none of my other peptides cause insulin resistance. Havent lost a single pound last week & I'm not sure why. My carb/calorie intake is extremely low & I go to the gym. Hoping things speed up by next week

 

[Pupsikas]

Tesamorelin has decent data for reducing visceral fat, but I wouldn’t treat it as a proven muscle-preservation aid, especially while not training. I’d stick to the basics, avoid a big deficit, keep protein high, recover, then restart lifting when cleared. Regaining lost muscle is faster than building it the first time.

 

[chewonmysac]

I just started mine 1 week ago exactly, my blood sugar levels have been high since starting tesa, with it being the main culprit as none of my other peptides cause insulin resistance. Havent lost a single pound last week & I'm not sure why. My carb/calorie intake is extremely low & I go to the gym. Hoping things speed up by next week

When starting Tesa, whether you cycle it or not, you can have slight water retention. Mine was about 3 lbs. Yes, it does create a temporary stall. That actually means it's working lol. As soon as you cycle off within days, you should get a decent flush of the water retention. I did. On my second cycle now, not for weight loss but for the reconfiguration of my stomach from the inside out. My goal was to reduce visceral fat surrounding my organs. I can feel the Big Macs melting away from my liver

 

[DustAndDignity]

Been on 5mg Tirz since December '25 and looking to introduce a weekly 5mg tesa dose to preserve muscle and attack visceral fat. Trying to keep number of peps at a minimum, reduce unnecessary pinning and risk of side effects whilst sticking to the lowest effective dose.

Currently not training due to a fracture but hoping to hit the gym once I recover.

Anyone try this and how did that work out for you?

Just to clarify are you saying 5mg once a week? Or spread out over a week?

I run both Tirz and Tesa and have found that Tesa slowed my weight loss significantly once I started. I actually put on weight which is commin do to water retention. I love Tesa tho, I sleep like a champ and my strength training has improved even with a small reduction in frequencies of lifts.

Is encourage you to hold tight on starting it until you’re back in the gym to reap what I believe through my personal experience to be the full benefits.

 

[70707]

I just started mine 1 week ago exactly, my blood sugar levels have been high since starting tesa, with it being the main culprit as none of my other peptides cause insulin resistance. Havent lost a single pound last week & I'm not sure why. My carb/calorie intake is extremely low & I go to the gym. Hoping things speed up by next week

I am probably holding off for the time being. I still have some weight to go and it would make sense to introduce tesa at a later stage.

 

[70707]

Tesamorelin has decent data for reducing visceral fat, but I wouldn’t treat it as a proven muscle-preservation aid, especially while not training. I’d stick to the basics, avoid a big deficit, keep protein high, recover, then restart lifting when cleared. Regaining lost muscle is faster than building it the first time.

The more I research the less likely I am to go for tesa (at least for the time being.) Mots-c might be a valid option though, starting from now and continuing once I'm back to working out.