Technically Possible To Combine Reta/Tirz w/ Eloralintide?
- Thread starter Spork
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I did. Fresh vial. Felt great today. Food noise is pretty quiet as well. Tuesday and Wednesday are my typical higher-calorie days, but not this week. I have had to remind myself to eat. Moderate dry mouth throughout the day. A bit thirstier, but other than that, smooth sailing so far. Still pretty early.Thanks for checking in.Grogu said:@chewonmysac
How you feeling? Did you pin your tirzepatide today?
Just want to make sure you're still alive and kickin'.
Regimen. $40 a year.Masil said:
Day 6 update. So far so good. Down 2lbs this week. This seems to do exactly what is intended. I will take it again this week and keep it at 1mg. The half-life is a key component. 14 days, so I fully anticipate a rise in med levels every 7 days with higher saturation.
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Dry mouth. Thirst uptick. Probably needed anyway tbh. So far, that is the extent. Pretty damn clean.Gohengrin said:
Peptidase said:
Peter hinted in an interview that he's tested another sample of eloralintide from another manufacturer, but didn't disclose the name. Hopefully we'll figure out who soon.
Changsa has it in productionPeptidase said:
Oh, cool! I have NOT seen reta/cagri yet - that's my fave! The search is ON!CNCCurrency said:
It is 14 days. My app actually had it preloaded. Kinda wild. Regimen.yeddie said:
First, I wanted to say thanks for all the prayers from my fellow Freaks!
Update week 2. Took 2nd dose yesterday. 1 mg again. As you can see with the 14-day 1/2 life, the medicine has increased. The level of saturation will only increase. The half-life is twice the weekly dosage. No other GLP has this long a half-life. I have tried to time this 2 days prior to my normal weekly Tirz (15mg) shot. Again this week, those days the food suppression, which normally fades, has been suppressed. I am eating because I have to hit my Calories. Yesterday, I noticed an 8-point uptake in RHR. That has subsided. The thirst and dry mouth remain but have reduced. All is good. If stacking low and slow is the move. Down 3 lbs in the last 10 days. At this stage (13 months), that number is well above average, as my weight loss has come to a crawl.
Update week 2. Took 2nd dose yesterday. 1 mg again. As you can see with the 14-day 1/2 life, the medicine has increased. The level of saturation will only increase. The half-life is twice the weekly dosage. No other GLP has this long a half-life. I have tried to time this 2 days prior to my normal weekly Tirz (15mg) shot. Again this week, those days the food suppression, which normally fades, has been suppressed. I am eating because I have to hit my Calories. Yesterday, I noticed an 8-point uptake in RHR. That has subsided. The thirst and dry mouth remain but have reduced. All is good. If stacking low and slow is the move. Down 3 lbs in the last 10 days. At this stage (13 months), that number is well above average, as my weight loss has come to a crawl.
I had a look at the eloralintide papers yesterday, and found the half life info confusing. At all doses tested from 0.1mg to 12mg the half life was about 2 weeks but at doses of 1-4.5mg the half life was about a week. This does not really make a lot of sense, it is not impossible for drugs to have complex pharmacokinetics with different rates of decay at different doses, but I could not make sense of what the practical real world half life was, except probably a week at least at lower doses. Hopefully some bigger studies will clear this up, or I am misreading something. Obviously the people doing that app think it is 2 weeks.
Also found the weight loss did not look like it was anywhere near plateau at 48 weeks, so max weight loss for elora is likely to be better than the numbers seen so far, and in rats at least it had better lean mass preservation than cagrilintide, especially at lower doses. ( high doses tended to make them eat nothing for a week which might explain this effect being different at high doses.)
Also found the weight loss did not look like it was anywhere near plateau at 48 weeks, so max weight loss for elora is likely to be better than the numbers seen so far, and in rats at least it had better lean mass preservation than cagrilintide, especially at lower doses. ( high doses tended to make them eat nothing for a week which might explain this effect being different at high doses.)
lessthanhalf said:
Eloralintide, a selective, long‐acting amylin receptor agonist for treatment of obesity: Phase 1 proof of concept - PMC
Eloralintide (LY3841136) is a potent, long‐acting selective amylin receptor agonist currently under development for the treatment of obesity with once‐weekly subcutaneous dosing. This 12‐week Phase 1, randomised, placebo‐controlled, participant‐ and ...
pmc.ncbi.nlm.nih.gov
The half-life is 12-14 days, per the studies, not just a random number from the app. I was surprised the app was correct.
You are right I did misread it, and mixed it up with the cagrilintide half life.
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