Switching from Reta to Tirz?

[Gohengrin]

Hello everone!

Many of you switchedbfrom Tirz to Reta after a while.

But has anyone done it from Reta to Tirz?

I consider it, because of the injection site irritations like big Red Spot, itchy and flaring up old injections....especially mots c injection sites that were weeks ago.. No antihistamin helped so far and it takes about 5 days to go away. Tested everything from Bac water, only sterile injection water, different needles, spots and vendors. Always the same.

I heard Tirz could be a better fit if I have this Problem.

So, did someone switch from Reta to Tirz and what was the experience?

 

[woundcarping]

What was your current dose on Reta? How long have you been on it (steady state)?

One plan/theory I have is long term maintenance on Tirz after getting where I want on Reta. That plan involves coming down on Reta, when food noise/hunger presents to a level worth addressing, add Tirz to keep those levels to an appropriate level (hunger isn't bad), reducing the doses as symptoms allow. Pretty much the opposite of my Tirz to Reta bridge.

 

[Gohengrin]

I am on 10mg for a few weeks now. It started with 4mg.

Do reta for 18 weeks now. Pin every 6 days.

 

[woundcarping]

I don't figure there's a standardized procedure for Reta to Tirz bridging. I assume you're still working on losing weight.

I've been very mild to no adverse side effects on Tirz or Reta. Going from Reta to Tirz will lose GCGR signaling. If I was in that position I'd still follow my potential plan of coming off Reta and adding Tirz to control appetite.

Are you wanting to cold turkey reta or taper off?

 

[Gohengrin]

I plan to taper off.

 

[woundcarping]

I'd think tapering makes it easier to manage symptoms.

I was only at ~5.5mg Tirz peak and not steady state. I started taking small doses of Reta frequently to test for sides. Since starting the transition I've taken two Tirz injections peaking at 4.5mg and 3.5mg respectively, each a week apart from the previous but that timing was responding to hunger or food noise, the timing was incidental. Wednesday will be another week since my last Tirz injection. If Reta's GLP signaling is strong enough, I won't get undue appetite/hunger or food noise beyond reasonable levels. If I do, I'll take another dose, probably targeting for a calculated peak around 2.5mg (another 1mg stair step down).

 

[DunningKruger]

I'm wondering a few things before the switch.

I'm curious why you started Reta at double the standard starting dose?

How many mg is your vial? And how many ml are you pinning for your current dose?

I ask because I'm wondering if it's a case of too much too soon, and if it's also a case of too much volume being injected into the tissue.

I'm sorry that I can't help re: the switch and the potential taper, just curious about the reactions. Has it always been like this?

 

[woundcarping]

“It started at 4mg”

I took that to mean the ISR started at 4mg/weekly.

It seems possible and I hadn’t considered volume being an issue, but 5 days seems like a long time for a BAC bolus to stay red.

 

[lessthanhalf]

Local allergic reactions to any of the GLP medications are fairly common. They will usually not go away. Cross reactions are rare, so it is unlikely if you switched to tirzepatide you would be allergic as well, which is most likely what you will need to do.

 

[Gohengrin]

“It started at 4mg”

I took that to mean the ISR started at 4mg/weekly.

It seems possible and I hadn’t considered volume being an issue, but 5 days seems like a long time for a BAC bolus to stay red.

Started with 2mg weekly for 4 weeks. BAC Was and is not the issues. Other peptides do not htrigger the reaction with the same BAC. I also tested only sterile water and it was the same.