randompersonrandom said:
If you want to use up the tirz and not screw with what's working but the fatigue/dullness is getting you, a lot of people do a VERY light stack of Survodutide against their tirz. You might read up on it. I'm talking 0.3 mg a week for the first month, 0.6 after that, and not much higher than that. I don't know the science on why it seems to help, but I feel like it does for me.
I stacked when switching to Reta, then did Reta alone, now I’m stacking again. I switched because on just Tirz I have severe fatigue, severe issues with no food tasting good (so I drank unflavored protein in my coffee because I at least was getting my protein in), and severe constipation. If you do stack, start low. People who have elevated heart rates generally start too high or titrate up too quickly. I started w/1 mg Reta and 8 of Tirz. My sweet spot (best weight loss/least side effects) was 4 mg/4mg weekly.
Calm Logic said:
I can feel just as shitty on reta too. In the studies, fatigue is about the same with tirz and reta.
Reta may be overrated but not for the liver. So if you have a fatty liver, reta would be better/quicker for liver health. Reta is also better on paper for lowering LDL.
The studies do show faster weight loss with reta, but you have to get the dose up. Some people temporarily gain weight switching to reta.
Reta is definitely overrated when it comes to preventing muscle loss. Some studies even show a greater percentage of muscle loss with reta than tirz.
(Anyone with heart issues should not even try reta until it is FDA approved.)
Anyone with common sense can use Reta. I have AFib and have had no issues. Start low, wait a full month between increases and you should be fine. Any GLP has the potential to increase resting HR.
I’m sorry you felt bad on Reta- it was such a relief to have energy again. It definitely seems to not suppress appetite as well as Tirz for many, but fortunately I haven’t had that problem. My issue is I’ve lost weight more slowly on Reta.. but I’ve also changed to eating more real food instead of living on protein shakes. I have no idea about muscle loss, I have put some muscle on according to my “smart” scale, but I’ve also gotten more active since the fatigue is improved.
All in all, it’s a good option. Here is what I would do if I were you:
-If no aggravating side effects, max out on weight loss using your Tirz first- get to max dose while still losing weight and switch then.
-if you want to switch for fatty liver or faster losses and don’t want to wait, stack them. Don’t waste your Tirz.
-if you have side effects you can’t stand anymore, stack- you’ll still get relief from the sides as the Reta is titrated. And I titrated down on Tirz while increasing Reta. You might find that you like stacking- as you’ve read here, many do.
Whatever you decide, just be cautious. And good luck!
