Swap Reta for Tirz for Inflammation / Mast Cells

[drswole]

I certainly could see that there are a lot more Tirz users - in this case I've seen a few testimonials from mast cell patients who switched from Reta. I do think that the Glucagon activation's impact on heart rate is a negative for most of us that already have Dysautonomia or POTS of some type. I also have ADHD, so the anhedonia side-effect may be another part of the balancing act.

I was already having side effects at 2 mg Reta to where I tapered back, and I escalated rather slowly over time. The oddity is I had definitely impacts on appetite even from low doses, but suspected maybe inflammation was holding the weight from dropping. I wanted to see if I could reach 2.5 mg, but it wasn't to be. I dropped for a few weeks to 1.5 mg, and then to 1 mg. I felt better as I went along, both mood and other sensory issues seemed to fade out.

So, yesterday I had my first dose of Tirz at 1 mg. I definitely felt something different, and so far I am going to say that I can understand what people were talking about. My respiratory function seems a bit less labored. My pain level is better, despite not getting to sleep until 4 AM, and I had two new lots of IVIg today for my infusion and I had almost no side effects, which is rather unusual.

My food noise is about the same, but it has been only a day, and I probably am still spinning down from the 1.5 mg doses of the past. Food tolerance is still fine, and if anything GI system is more quiet. Time will tell how this experiment goes - I wanted to see the difference before I suggested one way or another to other friends in the chronic illness group.

sounds like you have found what works for you though, so tirz is your answer! you can always experiment with other compounds to minimise inflammation as well if you think thats whats holding you back

 

[CuttingEdgeScience]

Not sure how your MCAS presents, mine is mostly itchiness if not managed with antihistamines.

Don't get your heart set on tirz or reta making everything better. They'll help you lose weight, which will make everything better, and maybe they lower some inflammatory biomarkers and potentially treat arthritis.

But for what you're after it sounds like you'd be better off adding BPC (specific applications for MCAS) and KPV.

Well, honestly with a Tryptase in the 30's and multifaceted disease - POTS/Dysautonomia, Small Fiber Neuropathy, Autoimmune Autonomic Neuropathy, Fibromyalgia, ADHD, IBS, ME/CFS, MCAS, Suspected Mastocytosis, Chronic Insomnia, history of Chronic Migraine... I've got a lot of symptoms. I get world-class medical treatment, but it still falls short and I am perturbed by those with POTS/MCAS regaling how GLP-1 cured everything, and wondering what is different about me.

What really sets me off about all this - I have not lost weight (at least on Reta) which makes me curious if the systemic inflammation is to blame. It is curious, BPC does seem to have specificity for the gut barrier, and calming immune activation. It touches mTOR and NF-kB both, so that checks out too. KPV seems to have similar mechanisms of suppressing activated inflammatory pathways. Maybe the controls aren't being tweaked enough to suppress the inflammation. If I have a clonal process, yet undetected, it would be keeping these pathways locked on via Tryptase signaling... all about throwing the right levers to reinstate some type of homeostasis.

 

[CuttingEdgeScience]

I was on a prescription anti-inflammatory for years, after a couple months on Tirz I came off it entirely with doctors approval, the Tirz is such a magnificent anti inflammatory for me, the old rx was just unnecessary

Good to know! I will definitely keep at it with Tirz and see how things play out. I suspect I may tolerate it, and higher doses better than Reta where I had side effects at pre-clinical doses.

 

[CuttingEdgeScience]

I have lupus and chronic pain issues. I kept hearing how good reta was so a few weeks ago I significantly lowered my tirz and added reta. Worst mistake I ever made! All my pain and inflammation came back with a vengeance and sent me into a lupus flare. I went off and upped my dosage of tirz again. I now use a little cag as needed.

I feel encouraged by your report - This week has been better than any in recent memory, and the Reta had positive effects that have persisted with improvement on Tirz. Very curious to see how that looks in the coming weeks and potentially with a dose increase. Currently at 1 mg. Case reports in MCAS showed even accidental increased doses were mostly positive.

 

[Pixel-pocket]

Tirz definitely reduced inflammation to almost non-existent, was on it 2+ years, but then stopped responding to it. Started Reta 6 weeks ago, finally getting some appetite suppression but does nothing for inflammation.. yet anyway.

Is Reta supposed to reduce inflammation?

 

[5byfive]

What really sets me off about all this - I have not lost weight (at least on Reta) which makes me curious if the systemic inflammation is to blame.

Are you tracking calories? How is your sleep? Have you started any type of exercise? Those are the most likely culprits (and also causes of inflammation).

 

[IronCircuit]

I'm going to be switching from Reta to Tirz, as I keep seeing testimonials from others that tout superiority for inflammation. As someone with POTS, MCAS/MC, et al. I have been floored at how I've been able to eat practically all the foods I lost in the past, but suspect I may see more profound changes to the root of inflammation on Tirz.

Can anyone comment on if dosages differ between the two? I had settled out on 1.5 mg Reta after I was getting side effects when I titrated higher. I have had greatly reduced food noise from Reta, but not significant change in weight (I am just above the "normal" range, but used to be lower before I fell ill.)

Any thoughts, commentary is appreciated!

I never did any other GLP before Reta.

What would you be “losing out on”, by not staying with Reta? Does Reta have better fat burning advantages mechanism where Tirz has better appetite suppression? What advantages (other than inflammation management) does Tirz have over Reta?

 

[CheesyPotato]

Is Reta supposed to reduce inflammation?

Not sure if it's supposed to, but the unexpected benefit from Tirz of reducing inflammation, I thought maybe Reta would have similar effects. Many posts I've read on various forums, researchers have stated inflammation was reduced. But also have read where it wasn't as effective either or actually made their joints ache, everyone is different but I had hopes it would help

Per EL themselves: Lilly is currently studying retatrutide in Phase 3 clinical trials for obesity, type 2 diabetes, knee osteoarthritis pain , moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatotic liver disease.

Phase 3 is complete, currently in TRIUMPH-4-in adults with obesity or overweight and knee osteoarthritis , and without diabetes, as an adjunct to healthy diet and physical activity.

It'll be interesting to see the outcome of this trial.

 

[JimGainz]

I really started to feel the Tin Man symptoms of total body stiffness and soreness in my early 50s and just figured I'm getting old. I loosen up when I get going (exercise or yard work) but then stiffen up when I go idle. My wife was on Sema and Tirz for two years with great success and she needs to restock. I am going to order T60 for the both of us to share and see if it helps ease the total body sore/stiffness

 

[Pixel-pocket]

I really started to feel the Tin Man symptoms of total body stiffness and soreness in my early 50s and just figured I'm getting old. I loosen up when I get going (exercise or yard work) but then stiffen up when I go idle. My wife was on Sema and Tirz for two years with great success and she needs to restock. I am going to order T60 for the both of us to share and see if it helps ease the total body sore/stiffness

Look forward on your updates as I live with chronic pain.

 

[Pixel-pocket]

I'm going to be switching from Reta to Tirz, as I keep seeing testimonials from others that tout superiority for inflammation. As someone with POTS, MCAS/MC, et al. I have been floored at how I've been able to eat practically all the foods I lost in the past, but suspect I may see more profound changes to the root of inflammation on Tirz.

Can anyone comment on if dosages differ between the two? I had settled out on 1.5 mg Reta after I was getting side effects when I titrated higher. I have had greatly reduced food noise from Reta, but not significant change in weight (I am just above the "normal" range, but used to be lower before I fell ill.)

Any thoughts, commentary is appreciated!

I wonder if we will see less weight measurements but higher body measurements as Reta targets fat rather than muscle?

 

[CuttingEdgeScience]

Are you tracking calories? How is your sleep? Have you started any type of exercise? Those are the most likely culprits (and also causes of inflammation).

Tracking, somewhat - I'm definitely eating less than before, and I wasn't consuming tons of calories to begin with. I rarely even snack anymore. Exercise has been increased as of late, especially since on the Tirz, I have found I can walk longer distances and have been out a lot more often. I also am just slightly overweight - so I don't know how that pans out vs how these drugs work in obesity, diabetes, etc.

 

[CuttingEdgeScience]

I never did any other GLP before Reta.

What would you be “losing out on”, by not staying with Reta? Does Reta have better fat burning advantages mechanism where Tirz has better appetite suppression? What advantages (other than inflammation management) does Tirz have over Reta?

Reta's activity at the glucagon receptor gives it greater fat burning potential as it amps up the metabolic rate and gets the body to burn more fat. However, it is also responsible for tachycardia and other side effects too. Tirz has, in my specific conditions, had a lot more testimonials for inflammation control.

I wish I could get more data on the interaction of these drugs at various receptors, it may explain some of the why - but I haven't found any studies yet.