SURMOUNT-4: Weight regain despite continuing lifestyle and diet modifications

[Habibibi]

I spend very little time thinking about whether I'll stay on a GLP1 for life. Of course, I will. Same for statins. The time I save not thinking about this is spent buying.

 

[Brouette]

I've already made peace with the fact that I'll be on a GLP1 for my forever. Not just for weight control, but because of all the ancillary benefits. I like the person I am now. I actually have control over food and my habits, not the other way around, and I'm not going to give that up. I've spent half my life trying to fight a losing battle. Been there, done that. I'm older, so it wasn't a hard decision.

This is the bess post ever!!! GLP1 help us to let " mental space" free of food noise, diet, training plan, meal prep, buying clothes who fit, etc. Its will be an eternal preoccupation, but we now have help to achieve goals. Thank you for that!

 

[skeptick]

I have tried every diet there is and always gained the weight back. So, it's not a surprise to me. On the other hand, here is what my weight loss and maintenance looks like 75 weeks in. I think I'll stick with the medicine for the rest of my life, thank you very much. View attachment 12478

Another peptide GOD in my book...

 

[randompersonrandom]

I'm not even mad that I'm gonna be on a glp-1 for life. My previous options were "be fat for life" and "be obsessing about how much I want food for life, and also probably be fat." The fact that I have the OPTION of "take an inexpensive shot weekly for life" is a miracle.

 

[Calm Logic]

Do you have the same " fear" as me that one day, the medication will stop to work on our body and we will have to look for something else for help?

Not really. We don't worry about exogenous testosterone not working anymore.

 

[anhydrous]

Do you have the same " fear" as me that one day, the medication will stop to work on our body and we will have to look for something else for help?

Fear not friend. There is endless money to be made and so the search for something else that works even better will never end. We'll all probably be on these for some period of time until something even better comes along. That is why I have a hard time stockpiling beyond 5-10 years worth.

 

[LabRatts]

Clearly, "remaining on the lifestyle interventions" was a lie. If someone could explain to me how someone could gain weight in a 500-calorie deficit and 150+ minutes a week of cardio, I would appreciate it.

THIS

 

[Calm Logic]

A potential advantage of cagri over GLPs for maintaining weight after stopping (or going on a lower maintenance dose):

Some researchers hypothesize that amylin analogues may be better at "resetting" the body’s adipostatic set point.

In obesity, the body becomes "leptin resistant"—it ignores the hormone that says "we have enough fat, stop eating." Most GLP-1s do not fix this; they simply bypass it.

The Amylin Fix: Preclinical and early Phase 3 data (REDEFINE program) show that amylin analogues sensitize the brain to leptin. By restoring this natural feedback loop, CagriSema may help the body maintain its own weight more effectively after the "chemical brake" of the medication is removed.

It could be Novo's best hope for their CagriSema having a competitive advantage over EL's tirz and reta, at least until EL's eloralintide gets to market.

OTOH, cagri slows the GI tract more than anything (that I can tell), so not ideal for me except at a low dose for a fiber-rich, plant-based diet.

 

[Cannonball72]

I have tried every diet there is and always gained the weight back. So, it's not a surprise to me. On the other hand, here is what my weight loss and maintenance looks like 75 weeks in. I think I'll stick with the medicine for the rest of my life, thank you very much. View attachment 12478

Preach.

I have had long successful periods of success, but that required unhealthy obsession disguised as discipline .

I love that I know how to manage my nutrition.

And I know how much easier it is to apply that information while on Reta.

Hit goal and microdose to maintain.