Starting to kick in?

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YoYoFat said:
Medical doctors will also tell you that food noise is mental chatter, it’s not a physical sensation the way hunger/appetite are.

Ozempic Quiets Food Noise in the Brain—But How? Blockbuster weight-loss drugs are revealing how appetite, pleasure and addiction work in the brain

Food Noise Versus Normal Hunger: What’s The Difference?

NIH on Food Noise
I always find it interesting when someone tries to tell other people how they feel. Doctors gaslighting their patients is very real.

My SIL was in labor but was turned away from the hospital because they are told that she wasn't really in labor. She was born on a couch. The hospital tried to charge her for the delivery anyway.

My husband was told that Lipitor couldn't possibly cause a heart attack or trigger his diabetes. Pfft.

My niece was told her son just had an ear infection that she shouldn't worry about it only for it to be a brain tumor. (incidentally this is the same niece that was born on a couch) Thankfully, my niece took her son to the ER anyway.

A whole lot of doctors are completely full of shit.
 
No idea what "food noise" means to each person, but I'll share the following observation:

(This is all pre-GLP1):

To me the most common sensation that I might call traditional hunger is when you're on a mixed-macro diet, that would usually come on if I hadn't eaten in a certain number of hours (maybe 4 or 5) and it was getting close to time for the next meal. This could intensify into "hangry."

With low-carb, the volume went way down for traditional hunger, but I'd still feel a non-hunger compulsion to eat (like my subconscious was nudging me towards doing so).

When I got into multi-day fasting, yet another sort of nudge would occur. It wasn't like the nudge I just described, but I'd all of a sudden get interested in binging different steak preparation techniques (as an example) on Youtube, as if my subconscious was trying a last ditch effort and screaming "hey, think about food and go eat something, you dummy!"

I think the most interesting takeaway there is that different sorts of sensations come in at different points and "hungry" really fails to appreciate the full range and how the different ones hit you differently.

To me a more interesting question was usually what it meant to be stuffed vs full vs satiated and what food combinations might trigger those different things and what it might all mean. Can't say I really answered that, but I kind of feel like "food noise" better fits in there, since it's a state where you're not hungry, but at the same time you're not satisfied either.

If you were a horse that was sodium deficient, you might feel compelled to start licking a salt lick (assuming one is nearby), whereas if you'd recently topped off on sodium, you might find that salt lick less interesting. I wouldn't be surprised if as food is more heavily engineered and delivered in combinations very different from what's traditionally available in nature, if that doesn't throw a wrench into things. For example, if I'm eating vegetables grown in magnesium-depleted soil (which is probably most farms), it wouldn't be surprising if my body realized it was low in magnesium, but not really sure what exactly to nudge me towards putting in my mouth to correct that. Same logic would apply to tons of other nutrients. I find myself wondering if food noise is sometimes downstream from an effect like that.
 
Week three now. Pinned on Monday. Still noticing that I'm filling up faster but now when I get hungry, I get HUNGRY! Strange for me. Also had a shit night sleep again last night. So pretty sure it's the Reta now. No weight loss yet.
 
Week four now. Pinned on Monday. Acid reflux woke me up that night. Shit sleep after. Got maybe 3 hours of sleep last night. Been belching for two days. Definitely stocking up on PPI's and antacids.

How long before your body acclimated to Reta?
 
Vash_ said:
Week four now. Pinned on Monday. Acid reflux woke me up that night. Shit sleep after. Got maybe 3 hours of sleep last night. Been belching for two days. Definitely stocking up on PPI's and antacids.

How long before your body acclimated to Reta?

You can get generic Voquezna from India. Works like a miracle compared to Protonix, etc.

All Day Chemist

doesn't require a prescription (even if it seems like it). They shipped to me from Europe and Asia rather than India, despite selling meds from India. Took maybe 10-14 days to arrive.

Vash_ said:
How long before your body acclimated to Reta?

I have been on various GLPs since March, including reta. Far less often now, but I still get GLP-induced heartburn now-and-then, like when changing things around or raising the dose.
 
I'm just planning on getting something from Walgreens. Pepcid or the like. The acid reflux is just the first night. The insomnia though.. sucks.

Thinking of splitting my dose next week. 2mg wasn't too bad. 3 has me out of whack.
 
You may want to check your heart rate. Some people quit reta because of the stimulation (insomnia and/or elevated heart rate). On the more extreme end, a resting heart rate above 100 would definitely be a good reason to quit.

As you say, splitting the dose may help. Some other advice is to stay hydrated and consider electrolytes, which can help the nerves and heart. Magnesium glycinate is the best form of magnesium for sleep (and lowering heart rate):

Tirzepatide seems to be worsening my problem with insomnia:

Started on tirzepatide at 2.5 mg one dose per week back in August and have gradually worked my way up to 5.0 mg in one injection weekly. I am an old fart and have to get up to pee 2 to 3 times nightly. (I've had a TURP.) In the past, most nights I would go right back to sieep. Some nights I...

glp1forum.com

A sleep expert on TV once recommended just 1 mg of melatonin a few hours before bed. Haven't tried it myself. Marijuana gummies always work for me for problems sleeping.

By the way, if the heartburn or heartburn-related insomnia comes back, I have slept in a recliner. Sleeping on my left side also helps.
 
MsGizmo said:
Well, you know the old saying .. opinions are like assholes .. everyone has one.

Psychologists say its a mental issue to their customers.

Surgeons tell you they can solve obesity by cutting up your stomach and intestines.

Fitness trainers say you just have to exercise more.
and everyone thinks that their opinion/asshole is the one that don't stink...
 
skeptick said:
and everyone thinks that their opinion/asshole is the one that don't stink...
I'm not the one telling other people what to think and feel.
 
Vash_ said:
Week four now. Pinned on Monday. Acid reflux woke me up that night. Shit sleep after. Got maybe 3 hours of sleep last night. Been belching for two days. Definitely stocking up on PPI's and antacids.

How long before your body acclimated to Reta?
Might be worth reading up on GLP1s and PPIs. Not saying you shouldn't take them together, just that a low acid environment combined with slowed gastric emptying can potentially lead to issues and it's worth reading up on those issues to avoid surprises and know if there's anything worth being aware of.
 
Vash_ said:
Week four now. Pinned on Monday. Acid reflux woke me up that night. Shit sleep after. Got maybe 3 hours of sleep last night. Been belching for two days. Definitely stocking up on PPI's and antacids.

How long before your body acclimated to Reta?

Famotidine has faster onset for gastric acid reduction if you’re not taking something daily. Omeprazole takes several days of dosing to reach steady state. There is also some association between omeprazole and depression, so that’s a consideration with the anhedonia s/e some GLP1s cause.

Also, I’d consider trialing some simethicone too if you’re bloated? Avoiding fodmap foods might also help with gas if gastroparesis slows gastric transit allowing food to ferment…
 
Calm Logic said:
You may want to check your heart rate. Some people quit reta because of the stimulation (insomnia and/or elevated heart rate). On the more extreme end, a resting heart rate above 100 would definitely be a good reason to quit.

As you say, splitting the dose may help. Some other advice is to stay hydrated and consider electrolytes, which can help the nerves and heart. Magnesium glycinate is the best form of magnesium for sleep (and lowering heart rate):

Tirzepatide seems to be worsening my problem with insomnia:

Started on tirzepatide at 2.5 mg one dose per week back in August and have gradually worked my way up to 5.0 mg in one injection weekly. I am an old fart and have to get up to pee 2 to 3 times nightly. (I've had a TURP.) In the past, most nights I would go right back to sieep. Some nights I...

glp1forum.com

A sleep expert on TV once recommended just 1 mg of melatonin a few hours before bed. Haven't tried it myself. Marijuana gummies always work for me for problems sleeping.

By the way, if the heartburn or heartburn-related insomnia comes back, I have slept in a recliner. Sleeping on my left side also helps.
I forgot about that. I've had a few days where my heart rate was over 100 all day. The first day coincided with my father-in-law's passing so, I attributed it to stress. But, I've had it a couple times since. My normal resting heart rate is 61. Which is high for me but, I've been slacking on my cardio.

I've been adding a pillow the first and second night to help with the reflux. I actually have a history with reflux. When I was a kid, I had to put bricks under the headboard to keep me elevated.

I think I'll split the dose this coming week and see how it goes. At the moment though, I don't think my mom would be able to handle these side effects. Especially without any positive results. Might need to have her start on an ultra low dose, like .5mg. Maybe add .5mg every four weeks. Might just not be for her though.

edit: After reading through my log and my posts, I think I probably just escalated my dose too quickly. Probably should've stayed at 2mg for longer.
 
Similarly, from the Meso forum, regarding tirz vs reta:

"More sleep issues associated with Reta. It raises base metabolic rate, particular through heart stimulation. Newer is not always better, depending on needs."

Tirz is my first love, haha. But it's shocking to see love for tirz at Meso.
 
Calm Logic said:
From the Meso forum, regarding tirz vs reta: "Newer is not always better, depending on needs."

Tirz is my first love, haha.
True Story. I've never tried Sema or Tirz because I didn't want appetite suppression. And, mom felt like shit on Sema. I hoped Reta would be a possible alternative.
 
GLP1Pharmacist said:
Eating too much and too late will cause problems at night too. Several months in had zero issues.

Almost 24/7 heartburn was a big motivation for me losing weight (and getting on GLPs to lose weight). Once it gets really bad, just drinking a little bit of water is enough to trigger it.

For almost 24/7 heartburn like mine was, I am all for healing the lining with Voqueza (or its Indian generic vonoprazan) for a couple weeks, despite the risk of bacterial overgrowth while on GLPs.

Even after losing 50 pounds and no longer being obese (still overweight), taking too much GLP can bring the heartburn back for me along with other GI sides, but nothing like it was before.
 
GLP1Pharmacist said:
Eating too much and too late will cause problems at night too. Several months in had zero issues.
I typically have dinner at 4pm and track my calories.
 
I have been drinking coffee again lately but it's over again for coffee too. Too triggering for me for heartburn. And all the cool kids are still drinking energy drinks, haha.
 
Calm Logic said:
I have been drinking coffee again lately but it's over again for coffee too. Too triggering for me for heartburn. And all the cool kids are still drinking energy drinks, haha.
I've noticed some very minor heartburn too.

Interesting heartburn anecdote:

Suffered for years from waking up with GERD during the night, treating with Tums at first before figuring out PPIs, which totally resolved it. As I ran into health problems, it was surprisingly treating sleep apnea with CPAP that completely eliminated my GERD (where I no longer took PPIs for it) and it was gone 100%. About 9 months later I finally fixed my diet and lost a bunch of weight, which had other benefits, but it was CPAP that resolved my GERD.

Reta heartburn seems different, closer to the round the clock kind you're describing. But it's only been 2 or 3 days where it's been at all noticeable at a lower level. Wouldn't be surprised if it's diet and dosage (current blood level) related in some way, but haven't nailed that down yet.
 
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