Specific ? about IBS difference from Tirz to Reta

[spanky2026]

Curious question: I had IBS for over 4 decades, eating in the morning and having to rush to the bathroom within an hour was an every day part of my life. Day One on Tirz and that disappeared. Totally. A return to perfectly normal bowel movements. I know that with Tirz the delayed emptying likely explains this, but I'm curious about Reta, and if I switched to Reta from Tirz would the IBS return, because the mechanisms by with Reta does it's thing are different? Can anyone speak to this? TIA

 

[wheymaster1]

The mechanisms aren’t different, it’s just that Reta activates the glucagon receptor on top of the GLP and the GIP like tirz. Theoretically it shouldn’t but you may need to stay the two first while tapering up reta and tapering down and eventually getting off of Reta in a 2-4 week interval. Choose a period when you’ll be less busy in case IBS returns..

 

[spanky2026]

The mechanisms aren’t different, it’s just that Reta activates the glucagon receptor on top of the GLP and the GIP like tirz. Theoretically it shouldn’t but you may need to stay the two first while tapering up reta and tapering down and eventually getting off of Reta in a 2-4 week interval. Choose a period when you’ll be less busy in case IBS returns..

I'm retired, lol, I'm always less busy! But yes, good advice, thanks. Haven't pulled the trigger on any reta just yet, hanging back on that, waiting for....I don't know!

 

[woundcarping]

Curious question: I had IBS for over 4 decades, eating in the morning and having to rush to the bathroom within an hour was an every day part of my life. Day One on Tirz and that disappeared. Totally. A return to perfectly normal bowel movements. I know that with Tirz the delayed emptying likely explains this, but I'm curious about Reta, and if I switched to Reta from Tirz would the IBS return, because the mechanisms by with Reta does it's thing are different? Can anyone speak to this? TIA

I had more enjoyable gastric slowing bathroom experiences with Tirz than with Reta, but Reta on the average is better than the baseline. Recency bias from dose escalation is probably causing an understatement of "better than the baseline."

Why are you wanting to switch to Reta?

 

[spanky2026]

I had more enjoyable gastric slowing bathroom experiences with Tirz than with Reta, but Reta on the average is better than the baseline. Recency bias from dose escalation is probably causing an understatement of "better than the baseline."

Why are you wanting to switch to Reta?

I do not know that I am, I'm really just trying to learn about Reta, how the experience is any different. I'm doing well with Tirz down 30 pounds in a bit over 3 months, but still a ways to go. I guess Reta is on my radar in case I end up "topping out" on Tirz dosing and/or it stops working for me, but either of those possibilities is still a way off. I mostly asked the question because after 40 years of IBS I dont want to even THINK about it returning, wondered if anybody had the experience of it returning after Tirz.

 

[woundcarping]

I do not know that I am, I'm really just trying to learn about Reta, how the experience is any different. I'm doing well with Tirz down 30 pounds in a bit over 3 months, but still a ways to go. I guess Reta is on my radar in case I end up "topping out" on Tirz dosing and/or it stops working for me, but either of those possibilities is still a way off. I mostly asked the question because after 40 years of IBS I dont want to even THINK about it returning, wondered if anybody had the experience of it returning after Tirz.

How much is a ways? I'm down 53lb since December when I started Tirz, 43lb since Jan when I started Reta, still have ~40lb to go.

I switched to Reta and worked up to an aggressive dose to get the odds in my favor that I'll be a high end responder relative to the trials, 24% losing 30% or more at 12mg. My target is somewhere in the 32-35% range.

 

[lessthanhalf]

I have ulcerative colitis with ongoing symptoms in "remission" or IBS-D or both.

What made the biggest difference was massive diet changes and losing 70kg. Just eating less calories overall helped, as well as less calories per meal, and reducing fodmap intake.

Starting ozempic helped as well, and this persisted when I swapped to tirzpatide 15mg/w , and did not change when I added reta 5mg/w, but I stayed on tirz as I had few side effects and my gut was stable and did not want to risk messing it up. Symptoms not gone but are much improved