瑞塔，这些副作用是暂时的，你的副作用持续了多久才消失？

[bgddy32]

我先说说我的情况。我原以为腹胀和便秘是必然的，但到了第三周，我发现情况有所好转。所以我想问问大家，其他人之前有没有出现过哪些副作用，后来身体适应后就消失了？

睡眠方面也有所改善，不知道是不是也能有所好转。

 

[smallbrainchud]

没有腹胀，但口干持续了好几周。皮肤敏感持续了两个月，还没消失。心率大约一个月后就恢复正常了。睡眠一直没问题，不过我服用褪黑素好几年了，所以也不知道为什么。除了偶尔皮肤敏感带来的不适感之外，没有任何其他疼痛或肠胃问题。两个月过去了，我晚上睡觉时仍然感觉很冷，但白天开空调却没问题，这很奇怪。

不经常排便这件事真的需要好好适应一下，哈哈。

 

[BNLFL]

睡眠方面也有所改善，所以我想这或许也是我可以期待的事情之一。

不确定你现在服用的剂量是多少。至少对我来说，剂量增加后症状会加重。我一开始是6毫克，后来增加到8毫克。另一个症状是烧心，我只有在注射当天晚上睡觉前偶尔会烧心。刚开始服用的时候，我每晚都会烧心。

 

[bgddy32]

不确定你现在服用的剂量是多少。至少对我来说，剂量增加后症状会加重。我一开始是6毫克，后来增加到8毫克。另一个症状是烧心，我只有在注射当天晚上睡觉前偶尔会烧心。刚开始服用的时候，我每晚都会烧心。

每周分两次服用2毫克，一个月后所有副作用都消失了，这让我非常惊讶……肠道功能也恢复正常了，昨晚睡了7个小时，一个月以来第一次。

我很好奇副作用的减少是否伴随着利妥昔单抗疗效的降低，比如食欲抑制（更容易饱腹）和进食时发出的声音消失了。我真的很想知道这一点，因为我不想超过4毫克，想尽可能长时间地保持2毫克的剂量。

 

[SoCalGirl]

头晕。持续不断的头晕。而且我的血压也太低了。我得在所有食物里都加很多盐，还要每天喝电解质饮料。如果当天的热量摄入不足，砰的一声，头晕就毫无征兆地袭来。希望这种情况在一两个月后能消失……

 

[Pete369]

GI issues settled after the first couple of weeks. Was a lot of ‘bowel clenching’ as if I had to have a BM but not much to work with and was only at 1mg split into two doses.

Titrating up to 4mg split in the second month I dealt with a lot of fatigue, likely from the reduced caloric intake but still keeping up my gym schedule.

Anhedonia settled in at 6mg and again, very noticeable back half of month two and through month 3. This was also where I noticed skin sensitivity.

Up to 8mg a week now in month 4. Energy has stabilized and the anhedonia is a fraction of what it was, skin sensitivity has increased. It’s not painful really but it is irritating, especially around waist where pants sit and my shirt ‘rubs’ my back.

 

[bgddy32]

GI issues settled after the first couple of weeks. Was a lot of ‘bowel clenching’ as if I had to have a BM but not much to work with and was only at 1mg split into two doses.

Titrating up to 4mg split in the second month I dealt with a lot of fatigue, likely from the reduced caloric intake but still keeping up my gym schedule.

Anhedonia settled in at 6mg and again, very noticeable back half of month two and through month 3. This was also where I noticed skin sensitivity.

Up to 8mg a week now in month 4. Energy has stabilized and the anhedonia is a fraction of what it was, skin sensitivity has increased. It’s not painful really but it is irritating, especially around waist where pants sit and my shirt ‘rubs’ my back.

So you noticed symptoms settling before titrating but did you titrate because the symptoms stopped and the effects from reta were slowing down?

 

[BNLFL]

2mg split dosed weekly, I'm really shocked at exactly one month in all my side effects have stopped... bowels back to normal , last night got 7 hours for first time in a month..

I really wonder if reduction in side effects is accompanied by reduced effectiveness of the reta as in you dont feel the appetite suppression (fuller earlier) feeling and food noise thing. I really want to know this as I dont want to go past 4mg and want to stay at 2mg as long as possible

Then you're flipping lucky. We were on 4mg for 6 weeks, and that feeling just went flat. 6mg for 6 weeks, not much action towards the end of 6mg. Now 8mg is another story, I still feel totally full all the time. Appetite sucks, sleep sucks, but the heartburn has basically stopped. On 8 for 4 weeks and plan to stay here till I hit goal, about 10lbs more. Then I'll figure a maintenance dose.

 

[Pete369]

So you noticed symptoms settling before titrating but did you titrate because the symptoms stopped and the effects from reta were slowing down?

Both, the GI distress stopped and the next week the evening food noise came back pretty loud. I also went from 1mg, 2mg, 3mg, 4mg, 5mg, 6mg, 7mg, 8mg weekly with split dosing, didn’t just double like standard protocol. The above thresholds were just where I noticed the main side effects sitting in or dissipating. Only increased when I found myself craving food late at night despite a protein shake or something light.

 

[bgddy32]

Both, the GI distress stopped and the next week the evening food noise came back pretty loud. I also went from 1mg, 2mg, 3mg, 4mg, 5mg, 6mg, 7mg, 8mg weekly with split dosing, didn’t just double like standard protocol. The above thresholds were just where I noticed the main side effects sitting in or dissipating. Only increased when I found myself craving food late at night despite a protein shake or something light.

Ah okay seems like this is standard then 4 week cycles before your body adjusts before you slam it with more... damn i was looking forward to how i feel now lol

 

[Pete369]

Ah okay seems like this is standard then 4 week cycles before your body adjusts before you slam it with more... damn i was looking forward to how i feel now lol

I’ve read plenty of anecdotal experiences where people don’t feel the need to move past 2-4mg. I was already down from 295 to 235 though when I started and have been bouncing between 215 and 235 between summer and winter for the last two years. Already cut out most processed foods, wife has celiac and corn allergy so we eat mainly protein and veg, don’t snack on sweets much, have been consistent in the gym for 5 years and carry a good amount of muscle. I’m sure there’s a lot of factors at play on individual response and how much you’re restricting vs body’s energy demands.

 

[Mochizuki0124]

Bloating was bad for like a week or 2. I also learned real quick that my lactose intolerance is like 3x worst.

 

[bgddy32]

Bloating was bad for like a week or 2. I also learned real quick that my lactose intolerance is like 3x worst.

I feel that mine lasted 3 weeks lol