瑞他曲肽引起的疲劳/嗜睡

[byefatlicia]

Could you please tell me more about the Tirz/Survo stack? I'm willing to try anything because I hear so much good about Reta.

Look in the forums under Survodutide for allot of great discussions. Especially the stacking ones. From what i gather, when stacked with Tirz, it is essentially like Reta minus some Reta sides? I will do my own research and see for myself

Investigational/Trial Medications

Survodutide

 

[iamiPAC]

Look in the forums under Survodutide for allot of great discussions. Especially the stacking ones. From what i gather, when stacked with Tirz, it is essentially like Reta minus some Reta sides? I will do my own research and see for myself

Investigational/Trial Medications

Survodutide

Thank you! I’m still a new researcher so I’ve never even heard of Survodutide. AWESOME SAUSE! Tell me how your research goes..

 

[feijao]

Thanks for the detailed feedback. it helps!

If you don't mind me asking, and only if you don't mind, are you Male or Female? I'm curious because you mentioned estrogen levels and it would have different implications based on that. male here.

Male here. Dang, I knew that would be important to add, thought I went back and edited that info, guess not. Typically my estrogen comes back at 37 to 40, the time I felt so bad on Reta it came back at 11.4.

I guess theoretically reta could lower estrogen by reducing fat-mediated conversion of T to E, but I never lost enough weight for that to take place. I will try reta again in the future and get bloods taken again regardless of how I feel.

 

[Riddi]

Insomnia is hell. I’ve suffered for years and the only thing that helps me is Tizanidine. Helps me fall asleep, but not necessarily sleep long.

The thing that helped me most for sleep for some years was Boozeadine but I'm trying to get away from that now for other good reasons. =D

 

[Riddi]

GREAT QUESTION…

I’d love to share my experience with you. A couple of years ago, I started with Semaglutide (GLP-1) after hearing about it from a friend. Unfortunately, it didn’t work for me and even made me feel a bit nauseous. During the six months I was on it, I didn't notice any significant decrease in hunger or cravings. By the time I reached my seventh month, I felt it was pretty useless, so I decided to stop. Interestingly, I even ended up gaining weight during that time.

Fast forward to April of 2025, I tried an online virtual care doctor and got a prescription for a peptide called Tirzepatide (GLP-2), and it was a total game changer! I lost 30 pounds in three months by following a low-carb, no-sugar diet and working out five days a week. It really opened my eyes to the fascinating world of peptides. Now, I’m exploring some exciting options that BIG PHARMA might not want us to know about!

Currently, I’ve been on Retatrutide (retatrutide (because there is no such thing as "GLP-3")) for two weeks after transitioning from Tirzepatide . Recently, I experienced horrible fatigue and tiredness, which got me curious about whether my peptides were playing a role in that. To my surprise, I found out that Retatrutide could be the culprit. It was eye-opening since I had only heard about the amazing benefits of this peptide!

If you're curious, I recommend starting with Tirzepatide and seeing how it works for you. You can always upgrade to Retatrutide later if you’d like!

SORRY FOR THE LONG REPLY! Keep me posted on what you decide to do friend. BLESSINGS..

Thanks for that. Any length appreciated! in fact, you inadvertently answered one of the questions i had about all this in my Que. I've been very low sugar, and carb conscious, most of my adult life. cycling from low carb to no carb on and off. Part of the reason is that being in full on ketosis makes me feel great. I've been wondering if i can do as much of that with these or if i need to be more careful to not go too low in carbs as i may usually do.

My first hand research gave some clues. seems to me if you are running on ketones low blood sugar is less of an issue (but carbs may still be useful at certain points?) I'll be exploring the question further as i'm eager to know others exp in this also.

Saw you in Cali. I lived in Norcal a few years. wild experience. you too man, blessings back!

 

[Riddi]

The reason people feel sluggish on these drugs is because you aren’t eating. Other peps might give you a boost but it’s artificial. We really need to focus on what we are consuming and that we have a balanced diet. We are starving ourselves on purpose here to lose weight. The GLPs just make us not think about it.

This is an important point. I have been mostly no sugar - low carb to full ketosis for years and wondering how i need to address that regarding GLPs. Even with that approach, I think it may be optimal to have some carbs sometimes. If to reload Glycogen stores in liver or goose the metabolism a bit or any reasons i don't know.

When i was doing some small initial research with a glp i had been fairly low food and in ketosis i had 2 interesting experiences.

One was i had been low food with no hunger so one day i figured, "i havent eaten, why not not go to sleep and make this a one day fast." it had been a while since i've done that and the glp makes it easy.. that went well so still fasted to next night i thought "why not make it a 2 day fast?" went to bed slept a bit then got up in night, restless, i wasnt hungry so went back to bed but still restless, wierd dreams, wake back up.. I knew i needed to eat if i would like to sleep so i made one of my go too: soft taco, low carb tortilla, meat, some cheese, letuce, and onions. slept like a baby.

I already know from reading in these places that you have to eat with these but i was only like 2 weeks in. (my thinking is it gets more important further down the road.)

Other experience was about a week later.. i had been rolling with the ketosis mostly in those weeks and was planning to have some carbs to reload. was thinking last 2 days i would go with normal spaghetti with lowcarb meatballs and low sugar sauce. i rarely eat pasta but i am half Italian and grew up with an Italian Grandmother so i do find italian food wonderful even if i don't eat it much for other reasons.. I did the deed. it was great. normally a meal like that would put me in a carb coma if i dared eat it. I had even done it at a day i knew i could sleep a few hors afterwards if needed. funny thing was, i felt supercharged, had no lul afterwards and ended up washing dishes and cleaning the kitchen (a lot as my wife and son were out of town visiting inlaws for those weeks but their return was iminent)

 

[FlowerFairy]

I found this interesting. Sub-Q? I don't want to assume it because based on your background you may have access to IV infusion. Would be nice to confirm if sub-Q works with Glutathione as IV would be outside of my reach. Any personal theory for the boost? Increased liver function?

I take my Glutathione SQ. I take everything SQ , I think. And I think infusion is the only area I haven’t even floated to. I’m guessing I feel better because I’m older- 62. It declines in your system as you age.

 

[Riddi]

I take my Glutathione SQ. I take everything SQ , I think. And I think infusion is the only area I haven’t even floated to. I’m guessing I feel better because I’m older- 62. It declines in your system as you age.

nice. thanks for the info.

 

[iamiPAC]

This is an important point. I have been mostly no sugar - low carb to full ketosis for years and wondering how i need to address that regarding GLPs. Even with that approach, I think it may be optimal to have some carbs sometimes. If to reload Glycogen stores in liver or goose the metabolism a bit or any reasons i don't know.

When i was doing some small initial research with a glp i had been fairly low food and in ketosis i had 2 interesting experiences.

One was i had been low food with no hunger so one day i figured, "i havent eaten, why not not go to sleep and make this a one day fast." it had been a while since i've done that and the glp makes it easy.. that went well so still fasted to next night i thought "why not make it a 2 day fast?" went to bed slept a bit then got up in night, restless, i wasnt hungry so went back to bed but still restless, wierd dreams, wake back up.. I knew i needed to eat if i would like to sleep so i made one of my go too: soft taco, low carb tortilla, meat, some cheese, letuce, and onions. slept like a baby.

I already know from reading in these places that you have to eat with these but i was only like 2 weeks in. (my thinking is it gets more important further down the road.)

Other experience was about a week later.. i had been rolling with the ketosis mostly in those weeks and was planning to have some carbs to reload. was thinking last 2 days i would go with normal spaghetti with lowcarb meatballs and low sugar sauce. i rarely eat pasta but i am half Italian and grew up with an Italian Grandmother so i do find italian food wonderful even if i don't eat it much for other reasons.. I did the deed. it was great. normally a meal like that would put me in a carb coma if i dared eat it. I had even done it at a day i knew i could sleep a few hors afterwards if needed. funny thing was, i felt supercharged, had no lul afterwards and ended up washing dishes and cleaning the kitchen (a lot as my wife and son were out of town visiting inlaws for those weeks but their return was iminent)

I’ve been Keto for years and Carnivore for the last couple of years and love eating this way. I did notice I don’t feel the best doing Carnivore while on Tirzepatide/Retatrutide so I now allow for some carbs, but most meals eat no carbs.

Love that I’ve met another Keto/Carnivore brother on here. BLESSINGS..

 

[Foggy-Hollow]

I've seen this in some threads and will be curious to see what people chime in with. Especially if some may weigh in with comparison regarding this subject and sema vs triz vs reta. Did you get the fatigue with triz?

我的样本量是1，所以这并非卡路里不足。我尝试过三种药物（S、T、R）的微剂量服用——每周一次，每次不到半剂量。服用这三种药物后，我都出现了“需要多睡一天”的疲劳感，而且食欲几乎没有受到抑制。这种情况通常

发生在第二天，而且我每天的饮食都一样，所以肯定不是卡路里的问题。服用Sema时，这种疲劳感甚至持续到了第三天。我坚持了三周，但感觉非常糟糕，于是就停用了。接下来我尝试了Reta，想着它或许能帮助提升精力，结果疲劳感只持续了一天，虽然还是会犯困。

我做了更多研究，决定补充电解质。无论疲劳的原因是什么，我知道我的体内电解质含量偏低，而补充电解质可能有助于缓解GLP-1受体激动剂引起的疲劳。在

服用半剂量Tirz的第一天，我早晚各输注一次液体电解质；第二天和第三天早上也输注一次，现在我的疲劳感明显减轻了。比如：周五下午服用，周六像往常一样躺下小睡，结果并不需要睡觉。

我对此非常兴奋，这说明这些肽类药物对我来说是可行的。

要找出疲劳的多种原因。可能并非是卡路里摄入量的问题。卡路里摄入时间和电解质补充都是需要考虑的因素，注意疲劳出现和消失的时间，从中寻找线索。

 

[Foggy-Hollow]

我是男的。哎，我就知道补充这一点很重要，我以为我已经编辑过那条信息了，看来并没有。通常我的雌激素水平在37到40之间，上次服用Reta后感觉特别糟糕，结果只有11.4。

我猜想Reta理论上可以通过减少脂肪介导的睾酮转化为雌激素来降低雌激素水平，但我体重下降的幅度不足以达到这个效果。以后我会再尝试服用Reta，无论感觉如何，我都会再去验血。

查看附件7950

这很有意思。

我刚加入了一个女性激素替代疗法（HRT）+ GLP-1 的小组（我48岁，正在接受HRT治疗——雌激素、孕激素、睾酮），小组里的女性都说她们服用GLP-1后雌激素水平也下降了。有一两个女性说她们的睾酮水平飙升（并非所有女性HRT都包含睾酮）。我一时想不起来具体是哪种GLP-1了。

我的医生是根据症状治疗，但会监测血液中激素比例。

你的睾酮水平是否高于预期？

 

[desinr-gal]

（见附件 7946） 今天早上，

我在 YouTube 直播中向“肽语者”亨特·威廉姆斯和他的妻子泰勒咨询了 这个 问题 ，他们建议我添加 NAD+ 和 MOTS-C 。因为我已经在服用 NAD+ 了，所以我会把 MOTS-C 加入我的研究范围。希望我的精力能恢复正常。如果不行，我可能就得重新服用替拉帕肽了。

各位朋友有什么想法吗？

Mots-C 和 Nad+ 对你来说效果如何？

 

[iamiPAC]

Mots-C 和 Nad+ 对你来说效果如何？

我还没试过MOTS-C，我正在用NAD+，但感觉还是摆脱不了疲劳的困扰。哈哈……你试过吗？

 

[desinr-gal]

我还没试过MOTS-C，我正在用NAD+，但感觉还是摆脱不了疲劳的困扰。哈哈……你试过吗？

不，我本来打算先做 SS-31，因为我年纪大了，而且肯定有线粒体损伤……但它被安排在 SS-31 之后。

 

[Mygfmademe]

The reason people feel sluggish on these drugs is because you aren’t eating. Other peps might give you a boost but it’s artificial. We really need to focus on what we are consuming and that we have a balanced diet. We are starving ourselves on purpose here to lose weight. The GLPs just make us not think about it.

Forgive me for fangirling, but I just gotta say thank you. I snuck over here a couple of months ago (TikTok of course) and I started watching your comments on here. Gave me great direction. I don’t talk on here or come here much more at all. But I gotta say you’re so helpful! I figured it was a sign since I love pandas or something lol so uh, I guess I gotta thank you because my body is much happier two months in lol

 

[AndyPanda]

Forgive me for fangirling, but I just gotta say thank you. I snuck over here a couple of months ago (TikTok of course) and I started watching your comments on here. Gave me great direction. I don’t talk on here or come here much more at all. But I gotta say you’re so helpful! I figured it was a sign since I love pandas or something lol so uh, I guess I gotta thank you because my body is much happier two months in lol

That’s very flattering. This community helps all of us. You are doing the work, and that’s why you feel better! Keep it up!

 

[dont_wanna_be_fat]

3 weeks into Reta, at 2mg/ 7 days right now. My experience so fas is that I need to be hypervigilant on what I eat and when. 30-45 mins before gym, whey protein shake (with almond milk) with a banana and a shot of espresso -- good energy for my workout. After gym, electrolyte drink, I use Propel fitness water packs. Next meal will have a min of 40g protein, low fat, moderate carb, trying to keep it around 450-500cal. Last meal will have 50g protein, lotsa veggies, and leave me with 200ish cals to spend on a greek yogurt/ frozen fruit smoothie. I work to be under 1800 cals/ day TDEE for me is 3,000.

So far I do notice a mild fatigue later in the day, worse if I am stuck at the desk working (I am a remote worker) and don't eat right, but not debilitating. I also acknowledge that I am new, and my dose is 2mg.

 

[BooneDonk]

Same with the late afternoon fatigue. My job isn’t physically demanding either. Going to add in some more research soon to see if that assists with it.

 

[Riddi]

My n=1, it is not lack of calories. I have microdosed all three (s, t, r)- less than half dose once/wk. I experienced “need to sleep an extra day” fatigue without much if any appetite suppression with all three.

I happens on day 2, and with eating the same each day, it’s something other than calories. It spilled into day 3 with sema. I lasted three weeks and had enough dark thoughts I stopped. I went to Reta next thinking it would help bolster energy levels, and it was down to one day of falling-asleep-upright fatigue but firmly there.

I did more reading/research and decided to take more electrolytes. Whatever the cause of loss, I know my system runs lean of them and that they might help with glp-1 fatigue.

I took liquid IV morning and evening of day one, morning of days two and three on a half dose of tirz and I am having FAR less fatigue. As in: Dosed on Friday PM, laid down for my usual Saturday nap and didn’t really need to sleep.

I’m VERY excited for this, it makes these peptides viable for me.

Pursue multiple causes of the fatigue. It may not be calorie count. Calorie timing and electrolytes are options, pay attention to when the fatigue comes and goes for clues.

Thanks for the feedback on this. I will be sure to watch electrolytes carefully. Now days that there are several options for electrolyte capsules, it has been a game changer for me. I can handle much more intake than i normally would.

 

[Riddi]

I’ve been Keto for years and Carnivore for the last couple of years and love eating this way. I did notice I don’t feel the best doing Carnivore while on Tirzepatide/Retatrutide so I now allow for some carbs, but most meals eat no carbs.

Love that I’ve met another Keto/Carnivore brother on here. BLESSINGS..

Great stuff! Regards friend.