Room Temperature Storage

[Int96]

I'm trying to make a list of the acceptable amount of time that peptides can be stored at room temp (59°F to 86°F) in a dark place either in a vial or pen once reconstituted.

Here is what I've found sofar:

Semaglutide - 56 days

Tirzepatide - 30 days

I'm trying to find any info about these:

Retatrutide - ???

GLOW (GHK-cu, TBC-157, TB500) - ???

NAD+ - "several weeks" ???

Does anyone have any info on this?

Thanks!

[edit]

Sources:

FAQs | Ozempic® (semaglutide) injection & pill

Find answers to frequently asked questions about Ozempic® (semaglutide) injection and pill, including prescribing and patient resources. Read Important Safety and Prescribing Information, including Boxed Warning.

www.novomedlink.com

How should the Mounjaro® (tirzepatide) KwikPen® be stored?

Information about how to store unused and used Mounjaro® (tirzepatide) KwikPens®, for UK registered HCPs in response to your question

medical.lilly.com

 

[zpped]

You've listed these days for sema and tirz but what criteria are you using to define "acceptable"?

 

[Chizikitide-1977]

No info on this, but an interesting topic. Just wondering, where did you get the numbers for sema and tirz?

 

[Int96]

This page for Sema:

https://www.novomedlink.com/diabete...ozempic/about/frequently-asked-questions.html

"After first use (up to 56 days): Ozempic® should be stored at room temperature 59°F to 86°F (15°C to 30°C) or refrigerated at 36°F to 46°F (2°C to 8°C)."

This page for Tirz:

https://medical.lilly.com/uk/produc...mounjaro-tirzepatide-kwikpen-be-stored-217607

"After first use, patients may store their pen at room temperature up to 30 °C and dispose of it after 30 days."

 

[zpped]

This page for Sema:

https://www.novomedlink.com/diabete...ozempic/about/frequently-asked-questions.html

"After first use (up to 56 days): Ozempic® should be stored at room temperature 59°F to 86°F (15°C to 30°C) or refrigerated at 36°F to 46°F (2°C to 8°C)."

This page for Tirz:

https://medical.lilly.com/uk/produc...mounjaro-tirzepatide-kwikpen-be-stored-217607

"After first use, patients may store their pen at room temperature up to 30 °C and dispose of it after 30 days."

Cool, but those are completely different formulations and criteria. It's useful to know, but you can't really apply it to what we have.

You need to run degradation tests at regular intervals multiple times and across multiple vendors. In order to build a dataset of average degradation over time. Some of that is being done but its slow and expensive.

I can say, we have data for tirz at 60days with about 2%, mots at ~0.5% over 2 weeks.

 

[GimmeABreak]

I'm trying to make a list of the acceptable amount of time that peptides can be stored at room temp (59°F to 86°F) in a dark place either in a vial or pen once reconstituted.

Here is what I've found sofar:

Semaglutide - 56 days

Tirzepatide - 30 days

I'm trying to find any info about these:

Retatrutide - ???

GLOW (GHK-cu, TBC-157, TB500) - ???

NAD+ - "several weeks" ???

Does anyone have any info on this?

Thanks!

[edit]

Sources:

FAQs | Ozempic® (semaglutide) injection & pill

Find answers to frequently asked questions about Ozempic® (semaglutide) injection and pill, including prescribing and patient resources. Read Important Safety and Prescribing Information, including Boxed Warning.

www.novomedlink.com

How should the Mounjaro® (tirzepatide) KwikPen® be stored?

Information about how to store unused and used Mounjaro® (tirzepatide) KwikPens®, for UK registered HCPs in response to your question

medical.lilly.com

I don't think you can make the assumption that lyophilized, reconstituted gray Tirz or Sema would be the same as branded.

With that being stated I have seen actual test results for reconstituted Tirz and it did not start degrading (primarily in purity) until >30 days. However, starting at day 31 it rapidly degraded to be sub 99% in just a few days and sub 98% at about three-weeks past the 30 day point. This was one test of one vial. It could vary from one supplier to the next. Bottom line is store it in the fridge or use it quickly.

 

[GimmeABreak]

Cool, but those are completely different formulations and criteria. It's useful to know, but you can't really apply it to what we have.

You need to run degradation tests at regular intervals multiple times and across multiple vendors. In order to build a dataset of average degradation over time. Some of that is being done but its slow and expensive.

I can say, we have data for tirz at 60days with

 

[zpped]

I think we are looking at the same test. I believe your response is referring to mass degradation and mine is referring to purity.

I edited to the number to the correct 2%

 

[GimmeABreak]

I edited to the number to the correct 2%

Gotcha.

 

[keangkong]

This page for Sema:

https://www.novomedlink.com/diabete...ozempic/about/frequently-asked-questions.html

"After first use (up to 56 days): Ozempic® should be stored at room temperature 59°F to 86°F (15°C to 30°C) or refrigerated at 36°F to 46°F (2°C to 8°C)."

This page for Tirz:

https://medical.lilly.com/uk/produc...mounjaro-tirzepatide-kwikpen-be-stored-217607

"After first use, patients may store their pen at room temperature up to 30 °C and dispose of it after 30 days."

I question whether the same information would apply to our research grade drugs which are stored in different solutions.