Retatrutide平台期/对Retatrutide的适应或耐药性
- Thread starter bluefootedboobie
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Anecdotally, cagri poops out sooner than later compared to GLPs. In any case, there is some reason it isn't more popular for stacking.lessthanhalf said:
I do have more GI sides than most/many, but the differences between the GLPs seem minimal to me. And I have tried all of them, including lira and orfo, except for maz. I never get nausea, fortunately, but I can get GI sides with any GLP (diarrhea, heartburn, gas, burping, bloating).lessthanhalf said:
By the time I got to 10 mg of tirz, some sides like diarrhea and bloating were so memorable that I can tell you where I was and the time of day, for even over a half a year ago.
At least at 1 mg or so of sema, I tolerated sema as well as the other GLPs. Only had one vial, so haven't tried it much. But I can't do more than 6 mg of tirz a week. I don't get any problematic heart or insomnia effects with survo or reta, so they seem just as good so far.
I did a Sema/Reta stack, but only because I was nervous about giving up the Sema. For first time in my life the food noise was gone, but I wanted to explore the additional benefits of Reta, so I added it. I have slowly titrated the Reta up while continuing 2.5 mgs of Sema per week. Around 8mg of Reta, I started having what I can only describe as "morning sickness" so I stopped the Sema. It's been more than a month. The "Morning Sickness" is resolved and my food noise is still well controlled, though I imagine there is still some Sema in my system.dndgeek said:
came to a stand still on Reta so tried increasing dose from 8mg to 10mg butt the GI side effects were brutal ( diarrhea instead of the constipation everyone talks about). Added a tiny amount of sema to my routine and the cycle broke and started loosing again without the side effects. Of interest, I just saw the unpublish data from Lilly on their reta and had a large drop out rate (12-18%) due to loosing too much weight! At top dose they lost 28.7% of their body weight.
Figured I'd post an update (a positive one).
I began taking cagrilintide last week, starting at the very low dose of 0.125 mg.
I felt
no bad side effects at all,
like my desire to eat had lessened a bit, and
my gastric emptying had slowed a little bit as well
...so a few days later I took another 0.125 mg, bringing me up to what many consider the standard "quite low" per week starting dose.
Bingo! At that 0.250 mg dose, I am unequivocally 100% feeling again like I did in my early days of reta. I'm not even quite two weeks in, but it's a certainty that the plateau is broken. I remain at the max recommended reta dosage of 12 mg per week.
Caveat #1: This is working for me, but obviously that doesn't mean it will for everyone else. Anecdotally, from looking around, although LOTS of peptides work on some folks and don't work on others, it appears to me that cagrilintide for some reason has an even greater variation on who it does and doesn't work on.
Caveat #2: I've felt two sides .. one, I've been cold, and two, I've felt very mildly sick or nauseous on and off. The latter has been extremely mild and for all I know could even be a coincidence.
I began taking cagrilintide last week, starting at the very low dose of 0.125 mg.
I felt
no bad side effects at all,
like my desire to eat had lessened a bit, and
my gastric emptying had slowed a little bit as well
...so a few days later I took another 0.125 mg, bringing me up to what many consider the standard "quite low" per week starting dose.
Bingo! At that 0.250 mg dose, I am unequivocally 100% feeling again like I did in my early days of reta. I'm not even quite two weeks in, but it's a certainty that the plateau is broken. I remain at the max recommended reta dosage of 12 mg per week.
Caveat #1: This is working for me, but obviously that doesn't mean it will for everyone else. Anecdotally, from looking around, although LOTS of peptides work on some folks and don't work on others, it appears to me that cagrilintide for some reason has an even greater variation on who it does and doesn't work on.
Caveat #2: I've felt two sides .. one, I've been cold, and two, I've felt very mildly sick or nauseous on and off. The latter has been extremely mild and for all I know could even be a coincidence.
I feel like I’m in a plateau myself 20 pounds down and I just went up from 2 mg a week to 3 hoping to break it. I’m not gaining so I’m happy about that but I’ve been stuck at the same weight for the past 3 weeks and it’s driving me bananas.
I do not really understand why people think super low doses should work . I do not know what weight you were starting from or how much you want to lose, or how long it took, but 20 pounds has to be between 5 to 10% weight loss which sounds about right for such a low dose.Uptoearly said:
Unless there are side effects that are a problem there is no even remotely logical reason not to increase doses when weight loss stops. And if obesity is severe and especially if there are obesity related health problems, increasing doses to the standard maximum dose of 12mg is what you should be aiming for, to reduce long term health consequences of obesity. ( not really proven for reta yet, but is for sema and tirz and very likely to be the case for reta )
I started at 188 pounds I want to get to 125/130 which is a healthy weight. I’m 47 female and I’m 5’2”. The increase seems to be working on apatitte ( I can’t spell and auto correct is being shit lol) suppression again. I’ve increased activity and I’m hoping to break this plateau
This is the same issue I’m feeling. Did you notice anything at 3 mg? I started on 2mg for the last 4 weeks and am going to bump up to 3mg on Monday. Hope it worksUptoearly said:
如果增加剂量对食欲有影响，那么你应该会在某个时候看到体重秤上的数字有所变化。假设你的初始BMI是35，初始体重是188磅，已经减掉了20磅，目标是减掉33%的体重，达到125磅。当然，你可以慢慢增加剂量，但除非你的反应远超平均水平，否则你可能需要服用全剂量才能减掉这么多体重。目前关于瑞他莫昔芬的最佳研究表明，服用12毫克剂量一年左右Uptoearly said:
，体重减轻了29%。所以，如果你的反应和平均水平一样好，那么服用12毫克瑞他莫昔芬应该可以达到130磅的目标体重。但除非最终增加剂量，否则这种情况发生的可能性很小。以你目前的年龄和体重来看，你可能患有代谢综合征。我不知道你的血压、血糖或血脂情况，但很可能它们都不太理想。如果你不确定，应该去做检查。在这个年龄段，你的心血管风险可能很高，虽然你需要这些指标才能确定。服用足量Reta很可能降低患糖尿病、心脏病、中风以及其他一系列健康问题的风险，而低剂量可能不如高剂量有效。我假设Reta也适用这一假设，因为Sema和Tirz已经证实了这一点，但Reta尚未完全证实，因为他们的研究尚未完成。
我真希望自己能在十年前，也就是你这个年纪的时候就开始接受降低心血管风险的治疗，在造成损害之前，而不是之后。
同上……没有“足够快”这一说。lessthanhalf said:
其中一种（GHRP-2）确实可以增加食欲，但像tesa这样更受欢迎的药物则没有这种效果：Tibial said:
Gemini said:
我在这里放了一张表格：
有没有人跟我一样，喝 Tesa 和 IPA 的时候总是感觉饿？
我看到这是一种“不太常见”的副作用，所以很好奇它的普遍程度如何。
glp1forum.com
If anything, I have been able to eat less on hex and HGH, just from being motivated to fast around them. I was stuck at 200 pounds for months (since I avoid higher doses of GLPs due to sides), but now the weight is going down again. Years ago without GLPs, intermittent fasting (even for just 12 hours, as now) is one way I would lose weight (before gaining it back).
Unless you're a super responder, I thought they were dose dependent, meaning higher does equal greater weight loss? Why not follow the drug company protocol and double your dose every 4 weeks? The studies show proven results.Quatroskin said:
I started by following the studies at 2mg and truthfully it hit me like a ton of bricks. No appetite, sleep was awful, constipation. But the last week and a half I feel the food noise coming back so I’m just going to bump it up 1 mg in hope it works without the same level of side effects I had when I first started.CNCCurrency said:
I think this is exactly the situation where following the trial dosing protocol is a bad idea and going up very slowly is a good idea. If you have side effects at low doses , and you want to increase doses after the side effects fade a bit, then going up a tiny bit at a time like 1mg is exactly the right approach. Or split dosing if the side effects are only an issue for a day or 2 after each dose. If you don't have side effects I do not think going super low or slow is needed.Quatroskin said:
There’s two types of secretagogues.Tibial said:
You have growth hormone releasing hormone (GHRH aka GRF) receptor agonists like tesamorelin, sermorelin, and CJC-1295. These can have a modest effect on appetite (because growth hormone has a modest effect on appetite) but they tend to be weight neutral (ignoring water retention) as growth hormone also increases energy expenditure.
And then you have the ghrelin receptor agonists (GHRP aka GHS) like MK-677, GHRP-2, GHRP-6, and ipamorelin. These are all targeting the ghrelin receptor which has profound effects on appetite (ghrelin is known as the hunger hormone after all). Sometimes people will that ipamorelin doesn’t do this, that it’s a selective ghrelin agonist that doesn’t cause the primary effect of the ghrelin receptor, but you’ll hear this from people microdosing 1/20th of the clinical trial dose. They simply don’t notice much of an effect on appetite because they’re taking too small of a dose for that to happen. If you start taking several milligrams a day like they did in clinical trials your appetite will definitely respond.
我每天服用9毫克Reta和2毫克Cagri，外加1毫克AOD，成功突破了平台期。体重从260磅降到198磅，目标是185磅，之后就需要一些数学知识来维持体重了。
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