Retatrutide 旅程前后

[zpped]

Little behind on my updates. Apologize in advance that I’m going to catch up

I did end up testing the BAC that I purchased on Amazon. Results in the photo. I also ordered from a more reputable source (I believe listed in a previous post).

Yeah, that's definitely on the Acidic side.

 

[Incognitodoberman]

Yeah, that's definitely on the Acidic side.

I’m glad I tested it. I ended up tossing it. It wasn’t expensive and I’d rather not use it.

 

[Incognitodoberman]

Well folks... this thread has likely come to an end.

Being narrow minded made me miss what could be a better opportunity...for me.

Why did I start with Reta before trying other GLPs? For me, as I started my research, Reta was highly sought after. The best thing out there! So why not just get the best if you can afford it. I zoned in and only read about Retatrutide. Learned all I could before purchasing it. Man, it felt like heaven when I got my first vial!

I'm in my 6th week and only dosing 1.5mg. Down 12 pounds. Hardly any side effects. It's perfect! Bought a kit or two... or three and the comfort of having this on hand was just that... comforting!

Until I started to read more and more about issues some people have when starting out on Reta and then maxing out and not having an option for another GLP that could continue to help.

So, for now, my stock of Reta will sit patiently in my freezer. I will be starting all over and with Tirzepetide. Maybe it won't work for me way down the road and I'll eventually need it. Maybe it'll become stranded. Who knows!

This is why it's so important to be open minded while you research. I wasn't and now I will start all over.

So many on Tirz, so I likely won't post updates anymore.

I hope this post is useful to someone that hasn't decided which pep to try first.

 

[peptidepower77]

"Until I started to read more and more about issues some people have when starting out on Reta and then maxing out and not having an option for another GLP that could continue to help."

Why would you quit reta if you're only on 1.5mg per week? The trial went up to 12mg per week, you have a ton of headspace to keep going up. With respect, I think you're worrying about a problem that doesn't exist at this point in time, and likely, given your response, won't exist in the future.

 

[Incognitodoberman]

"Until I started to read more and more about issues some people have when starting out on Reta and then maxing out and not having an option for another GLP that could continue to help."

Why would you quit reta if you're only on 1.5mg per week? The trial went up to 12mg per week, you have a ton of headspace to keep going up. With respect, I think you're worrying about a problem that doesn't exist at this point in time, and likely, given your response, won't exist in the future.

It may not ever happen, you're 100% right.

I've just started, and I can't determine if and when I'll ever get to 12mg. I just don't want that in the back of my mind. I don't consider myself young anymore, but I'm young enough that I could need GLP assistance for the next 25 years. It's more comforting knowing that it will be there as a backup. Maybe Tirz won't work well for me, who knows. Maybe there will be something better than Reta later, who knows. I'm willing to wait it out and see how things go.

 

[zpped]

Yeah, seems like your fearing a problem that doesn't exist. There is no reason to believe you have the potential to loose more weight by starting on a worse drug. That's just not how they work.

 

[PackmanJohnny]

Theres also no reason to think Reta will stop working, as the body doesnt seem to deal with as much receptor desensitization.

Something I commonly see with GLPs is the idea that you need to be on them forever.

I know people have results they never dreamed of on them - but thats not right. your body not being able to lose weight is either caused by you eating like an asshole and having no self control(which is fixable) OR its because something is wrong with your body and theres a 90% chance there is medication that can fix your body so you dont need the GLP forever.

hormonal issues or metabolic ones have adverse effects on your body besides making weight loss difficult, its better to figure out some of those issues with a doctor so you dont have long term complications OR get tied to being on a GLP forever.

 

[Incognitodoberman]

Theres also no reason to think Reta will stop working, as the body doesnt seem to deal with as much receptor desensitization.

Something I commonly see with GLPs is the idea that you need to be on them forever.

I know people have results they never dreamed of on them - but thats not right. your body not being able to lose weight is either caused by you eating like an asshole and having no self control(which is fixable) OR its because something is wrong with your body and theres a 90% chance there is medication that can fix your body so you dont need the GLP forever.

hormonal issues or metabolic ones have adverse effects on your body besides making weight loss difficult, its better to figure out some of those issues with a doctor so you dont have long term complications OR get tied to being on a GLP forever.

I hear what you're saying, however I think everyone's bodies handle things differently, based on several factors.

For someone like me, I guess I would fall into that category of eating like an 'asshole'. I have an addiction to food and great desires to binge eat. There is a genetic component to food addiction. I watched my mother struggle with this her entire life. I have worked with my doctor and therapist for quite some time, trying to find ways that may help suppress that constant 'food noise'. So far, a glp is the only thing that has helped.

From what I’ve been reading, as well as speaking with someone who has gone through this personally, it is possible that if you start with the most powerful option (triple agonist) and later a dual or single agonist, your body may adapt to all three pathways , so moving down to a dual or single agonist may be less effective.

Unfortunately, there are no trials that have directly tested going backwards (triple → dual → single). Most research goes the other way (single → dual → triple) when someone may plateau. Mechanistically, if you’ve lost response to Reta, you’re unlikely to get more from a weaker drug. However, you might maintain partial benefit (blood sugar, appetite control), but not the same degree of weight loss.

To each their own, and to me this feels right.

 

[zpped]

From what I’ve been reading, as well as speaking with someone who has gone through this personally, it is possible that if you start with the most powerful option (triple agonist) and later a dual or single agonist, your body may adapt to all three pathways , so moving down to a dual or single agonist may be less effective.

Please point to what you've been reading that says this. Every expert I've spoken too all agree that this is just uneducated speculation by people that don't know what they are talking about.

 

[MsGizmo]

your body not being able to lose weight is either caused by you eating like an asshole and having no self control(which is fixable) OR its because something is wrong with your body and theres a 90% chance there is medication that can fix your body so you dont need the GLP forever.

这与那些毕生致力于研究此问题的医生的说法截然相反。我前几天刚读到，至少有14种不同的基因标记与肥胖有关。虽然我不清楚究竟有多少种不同的疾病会导致肥胖，但这里仅列举几种：甲状腺功能减退症、库欣综合征、多囊卵巢综合征（PCOS）、普拉德-威利综合征以及某些下丘脑疾病。用于治疗其他疾病的药物，例如某些抗抑郁药、类固醇、抗精神病药和激素类避孕药，也可能导致体重增加和肥胖。你一方面提到“药物”可以“修复我们的身体”，另一方面又说我们终生不需要GLP-1类药物，这让我觉得很奇怪……那么，你到底说的是什么？我们到底需要药物还是不需要？

 

[desinr-gal]

也没有理由认为瑞达会失效，因为身体似乎不会出现那么多受体脱敏的情况。

我经常看到有人认为服用GLP类药物就必须终身服用。

我知道有些人服用后取得了他们从未想过的效果——但这并不正确。你的身体无法减肥，要么是因为你饮食不节食、缺乏自制力（这种情况是可以纠正的），要么是因为你的身体出现了问题，而有90%的可能性可以通过药物来修复你的身体，让你不再需要终身服用GLP类药物。

激素或代谢问题除了会使减肥困难之外，还会对你的身体产生不良影响，最好与医生一起找出这些问题，以免出现长期并发症，或者让你终身依赖GLP类药物。

嗯……女性晚年激素问题并不容易解决。没错，有激素替代疗法（HRT），但很少有医生愿意处理这类问题，因为激素水平会随着一天、一周等时间变化，所以很难确定具体情况。激素种类繁多，需要监测的指标也很多，而且整个身体都处于复杂的变化状态。你的观点既盲目又轻蔑，更不用说还带有侮辱性了。

 

[Incognitodoberman]

请指出你所读到的哪些内容支持这种说法。我咨询过的所有专家都一致认为，这纯粹是不懂行的人的无端猜测。

I spent way too much time trying to find the article I read last night about the potential effects of going backwards from a triple agonist to a dual or single — and I still can't find it, but I know I read it. Along the way, I ran into a few AI-generated summaries, but I don’t really consider those solid sources. That said, I did end up reading quite a few other articles and studies during the search.

The article that I read last night didn’t claim this happens to everyone , but it did say that switching from a high dose of something like Reta to a dual or single could possibly affect how much stimulation a person receives. It was framed more as a potential effect than a guaranteed outcome. I also talked to someone who went through this kind of transition himself, and his experience lined up with what the article suggested — so to me, that reinforces the idea that it’s at least possible.

If I’m remembering right, I also saw something about Phase 2 trial results where subjects were monitored to see if they'd plateau at high doses, and after 48 weeks, they did not. That's reassuring. Since Reta is now in its final trial phase, I’m really curious to see what kind of data comes out from the trial as it started back in 2023.

 

[zpped]

What would be the purpose of switching off of reta though? Reaching a plateau on reta, you're not going to lose more on tirz because you've already lost more than tirz is capable of giving you.

 

[Incognitodoberman]

What would be the purpose of switching off of reta though? Reaching a plateau on reta, you're not going to lose more on tirz because you've already lost more than tirz is capable of giving you.

I don’t know that I can answer that 100%, but I do feel I can trust in the information I’ve received. It made me second guess myself in that I’m going about things the wrong way (beginning with Reta). I can say this information came from a credible source, not something wonky like Reddit.

My challenge is that I can spend months researching and learning and still end up with conflicting opinions. Feels like a game of tug-of-war and trying to decide which team to stand with, even though both sides provide valid arguments. I guess that’s where personal experiences can add a layer of clarity that the data alone doesn’t always provide.

At this point, I’m still not entirely sure which direction to go. Since I don’t have Tirzepatide in hand yet, I do have some time to keep researching and figuring things out. Oddly enough, I had a dream last night that some friends wanted vials of Tirzepatide, and I ended up selling them all for $100 each. Maybe that’s a sign, but either way, I’m still giving myself time to decide.

 

[spyke65]

From what I’ve been reading, as well as speaking with someone who has gone through this personally, it is possible that if you start with the most powerful option (triple agonist) and later a dual or single agonist, your body may adapt to all three pathways , so moving down to a dual or single agonist may be less effective.

Theoretically Retatrutide is “the most powerful” option, but not necessarily. Your needs today could be vastly different than your needs months or years down the road when Retatrutide stops working for you. Your body may need the glucagon agonist the most right now but as you near your goal weight and maintenance, you may only need the GLP-1 agonist. Or you may need to add an amylin agonist to the mix.

Also, some food for thought, Retatrutide isn’t on the market yet and there are quadruple incretin agonists coming through the research pipeline right behind it. In particular, NA-931 (bioglutide) seems to have a lot of promise.

My personal justification for going from Semaglutide to Retatrutide is the same as why if I’m buying a new computer, I go for the best model I can afford. New technology will follow over time so I’ll take the benefits of the new technology until it no longer works then pick the next better that comes along.

 

[Incognitodoberman]

Theoretically Retatrutide is “the most powerful” option, but not necessarily. Your needs today could be vastly different than your needs months or years down the road when Retatrutide stops working for you. Your body may need the glucagon agonist the most right now but as you near your goal weight and maintenance, you may only need the GLP-1 agonist. Or you may need to add an amylin agonist to the mix.

Also, some food for thought, Retatrutide isn’t on the market yet and there are quadruple incretin agonists coming through the research pipeline right behind it. In particular, NA-931 (bioglutide) seems to have a lot of promise.

My personal justification for going from Semaglutide to Retatrutide is the same as why if I’m buying a new computer, I go for the best model I can afford. New technology will follow over time so I’ll take the benefits of the new technology until it no longer works then pick the next better that comes along.

I really appreciate this feedback; it’s very helpful. I’ve started to see some early information on the quadruple, though I haven’t explored it in depth yet, I imagine it will become the next highly sought-after GLP. The science behind these developments is incredible on so many levels. While working alongside researchers, in an entirely different field, I find it fascinating to follow the evolution of their work and see how consistently life-changing it continues to be.

 

[PackmanJohnny]

That is contrary to what actual doctors who have spent their lives studying the issue are saying. I read just the other day that there are at least 14 different genetic markers that contribute to obesity. While I don't know exactly how many different medical conditions contribute to obesity here are just a few of them: hypothyroidism, Cushing's syndrome, Polycystic Ovarian Syndrome (PCOS), Prader-Willi syndrome, and certain hypothalamic issues. Medications used to treat other conditions, such as certain antidepressants, steroids, antipsychotics, and hormonal birth control, can also lead to weight gain and obesity. I find it strange that you mention "medications" that can "fix our bodies" in the same sentence as you saying we won't need GLP-1 drugs for life .. so which is it? Do we need medicine or not?

The main difference is that the condition CAUSING the obesity is not being treated by the GLP-1. You also have to factor in what other damage that condition is causing your body that you are no longer attempting to treat because the most noticeable part (obesity) is no longer bothering you. Hypothyroidism, for example(which I am diagnosed with) can lead to Peripheral neuropathy, Cognitive issues, as well as endocrinal and reproductive disorders that are unrelated to the likely obesity-related issues like hypertension. When you take the GLP and lose the weight, you still have hypothyroidism and still carry the risk for the other negatives regarding that condition, where if you properly work out the needed medicinal treatment for your thyroid, you would more than likely not need the GLP and be able to lose weight with diet and exercise, and maintain that weight loss with good habits.

The GLP might be great at helping you relieve one issue in your body, but you may be doing yourself a disservice in the long run by not caring for the root cause.

BUT - ALLLLL of that applies to a rather small part of the population. The majority of overweight and obese people in America and other places are not obese because of a medical problem, theyre obese because they do not care for their bodies or have good habits, and being on a GLP for life because youre incapable of not eating cake is weak sauce. not ascribing that to anyone here, thats just my opinion of the general masses.

 

[PackmanJohnny]

Ahem.. problems with women's hormones later in life are not easily resolved. Yes there's HRT but very few docs want to deal with it, it changes throughout the day, week etc. so not easily determined there are many kinds to track and the whole body is in a changing situation with many complexities. Your exprssed viewpoint is blind and dismissive, not to mention insulting.

If your doctor 'doesnt want to deal with' your health, thats a shit doctor. I know healthcare is expensive and finding a good doctor can be hard, but that is not a good reason to dismiss HRT. My mother happens to be about 6 months into it now and she is having some fantastic benefits, both on the scale and in her energy levels, hair thickness, etc.

I'm really not sure whats insulting about urging people to be actually aware of their health. with the body as complex as you're saying, shouldn't we do as much as we can to be as healthy as possible? GLPs are wonderful tools, but they arent magical. If Im blind and dismissive for urging people to monitor their health and try treating actual conditions vs blindly relying on experimental drugs, so be it I guess lol.

 

[zpped]

and being on a GLP for life because youre incapable of not eating cake is weak sauce

Why do you care what other people do that has no effect on you? That's pretty insecure thinking.

 

[MsGizmo]

BUT - ALLLLL of that applies to a rather small part of the population. The majority of overweight and obese people in America and other places are not obese because of a medical problem, theyre obese because they do not care for their bodies or have good habits, and being on a GLP for life because youre incapable of not eating cake is weak sauce. not ascribing that to anyone here, thats just my opinion of the general masses.

You have zero idea of what percentage of obesity is caused by medical conditions. Doctors who study the issue can't even answer that. Obesity is a complex problem that is connected to genetic problems, hormonal problems and yes, mental problems. (For the record GLP-1 drugs ARE hormones)

If Im blind and dismissive for urging people to monitor their health and try treating actual conditions vs blindly relying on experimental drugs, so be it I guess lol.

Frankly, who the hell are you to judge complete strangers and make UNFOUNDED accusations that they are not monitoring their health to the best of their abilities?