Retatrutide 1 mg/week – When Did It Start Working for you?

[randompersonrandom]

Getting allodynia at the starting dose seems odd. I'd suggest not titrating up until those affects pass.

That was a weird feeling. I could rub a spot and be fine, but a T-shirt sliding across my skin and it felt like needles coming through from under the skin. I titrated up to 12mg eventually and never got the effects again.

Now my problem is food noise. Or I'm just burnt out on chicken and rice.

I had allodynia from my very first dose of tirz (2.2 mg). Woke up the next day, and my skin hurt just a little when I pushed on it. So I didn't push on it and forgot about it. I feel it on my legs when my pants move. It's been six months, and it's never lessened or worsened at any dose (currently at 8 mg).

I just stopped noticing it. The little mermaid got legs in exchange for pain when she walked, giving up being royalty, and throwing herself at some douche without being able to talk so that even if he DID love her, it was probably for f-'d up reasons. I got way more for way less.

 

[brettbierjunkie]

Started at 2mg and felt tge hunger suppression within a few hours. Didnt really hit that loss sweet spot until 4mg. Went all the way to 10mg and dropped back to 8mg as the allydonia was getting weird.

Currently down to 4mg as I'm training for some athletic stuff.

I started back in August and lost ~22 lbs. Don't have loads of weight to lose.

 

[RoadRash]

Getting allodynia at the starting dose seems odd. I'd suggest not titrating up until those affects pass.

That was a weird feeling. I could rub a spot and be fine, but a T-shirt sliding across my skin and it felt like needles coming through from under the skin. I titrated up to 12mg eventually and never got the effects again.

Now my problem is food noise. Or I'm just burnt out on chicken and rice.

I also got allodynia at 2 MG. It's annoying but everything else about Reta is so good I'm hoping that it eventually subsides.

 

[octopusthorpe]

I’m currently on retatrutide 1 mg per week, split into 0.5 mg twice weekly.

For those using the same or similar dosing:

After how long did you start noticing appetite suppression?

When did weight loss become evident?

What side effects did you experience, if any?

Sharing timelines and concrete experiences would be very helpful.

I'm on week 4 of the same protocol, pinning 0.5mg every Tuesday morning and Friday late afternoon. Noticed effects pretty much right away. Minimal impacts to RHR, HRV and sleep.

Some things to note: I originally lost 160lb 9 years ago via low carb, powerlifting and hiking, and have never been on any GLP-1 prior. I'm trying reta to combat the effects of perimenopause-related fat gain.

I noticed effects straight away - I'm eating the same foods I was eating before reta (high protein, moderate fat, low carb, only processed food is protein shakes), I'm just eating smaller amounts. Somehow managed to drop 11lb in 3 weeks so far. It's blowing my mind, honestly.

 

[DragonOfTheSea]

Having experienced the suppression of both Tirz and Reta, I find them very different. With Tirz it just quiets everything flat, very impressive, chose when to eat, and probably cut my per meal volume by 50% before feeling full.. IMO this was true “suppression”.

With Reta, if I ignore any feeling of hunger for too long I find it turns into feeling ravenously hungry, it comes on fast and hard and super intense like I haven't eaten in 2 days, but I’m totally stuffed after 5 bites of food and good for hours. Pretty wild ride sometimes. I’ve experienced this at 2mg, 4mg, 6mg..

 

[Pin&Play]

Having experienced the suppression of both Tirz and Reta, I find them very different. With Tirz it just quiets everything flat, very impressive, chose when to eat, and probably cut my per meal volume by 50% before feeling full.. IMO this was true “suppression”.

With Reta, if I ignore any feeling of hunger for too long I find it turns into feeling ravenously hungry, it comes on fast and hard and super intense like I haven't eaten in 2 days, but I’m totally stuffed after 5 bites of food and good for hours. Pretty wild ride sometimes. I’ve experienced this at 2mg, 4mg,

My experience with Tirz and Reta was similar in some aspects and difference in others. Even though I can't really compare since by the time I tried Reta I had built some GLP tolerance.

I spread 5 doses of 2.5mg tirz in 2 months. Food suppression was strong, and strongest 2-4 days after injection, I rarely felt hungry AND I was full super quick. I had to be cautious the first weeks. Main side effect was constipation, I had to learn to eat veggies lol. And lack of strength during workouts.

I tried Reta for the first time 4 days ago, 0.75mg. Food noise vanished after 24 hours. BUT once I start eating, I struggle to stop. Constipation is behind the corner if I don't pay attention to diet. Unfortunately is giving me very bad insomnia even at this dosage, so I'm probably gonna stop it

 

[itsmenotyou]

I have had my 3rd dose at 1mg and think it’s working I have some days I struggle to eat anything and have to force myself to eat.. but some other days like last night I ate too much chocolate.

I’m down 1.2kgs but feel super bloated all the time. Hoping that goes away soon

Going to stay on 1mg another few weeks at least then try 1.5mg see how that goes

Sometimes it’s hard ro know if I’m just not hungry or is the reta

 

[RicFlair]

For me personally i immediately felt the side effects and reduction of appetite the day after. Specifically feeling fatigue, slow gastric emptying of the stomach, tired very often, and sulfur burps. Weight of the scale has only gone down about 2 lbs so far after about a week and a half but i am very optimistic it will really adjust with my body and ill see great results after about a month

 

[deleted.user.19]

I had the suppressive effect in the second week with 1 mg.

In the first week i took 0.5 mg and felt nothing, but i knew that the body has to adapt slow on Reta.

Personally i don't wanna take more then 3 mg per week. Eating food should not be a fight. I could easily fast for days.

 

[Mugshotwock]

I’m currently on retatrutide 1 mg per week, split into 0.5 mg twice weekly.

For those using the same or similar dosing:

After how long did you start noticing appetite suppression?

When did weight loss become evident?

What side effects did you experience, if any?

Sharing timelines and concrete experiences would be very helpful.

I started on 4/10/26 at 1mg/wk (1mg per shot) and felt it within the next few hours.

I took my shot at 3:00 and I'm usually peckish for a snack by 8:00. That day I had no desire. I took before and after photos (evening and first thing in the morning) and all inflammation in midsection was gone. I'm now a week and a half in and down 4.5lbs. (Gym 5-6 days a week, PPL/UL split with 15 min jump rope at the end)

As far as side effects go: my heart rate was up for the first week. Into the second week, things seem to have calmed down. The fatigue is crazy when I don't get enough carbs. I've started drinking warm prune juice in the evening to make sure my movements are regular (they are thank goodness) and despite my appetite being in the dirt the first week, second week I'm able to finish the meals I make for myself and even get proper hunger cues.

I also used to smoke tree very consistently. I've smoked since I've started but the desire to do so has dropped significantly. I have a very addictive personality and the things that used to trigger me just...don't anymore. I can focus on work, school, my training, and proper eating more effectively.

Best of luck to you!

 

[Shutterdrive]

I have had my 3rd dose at 1mg and think it’s working I have some days I struggle to eat anything and have to force myself to eat.. but some other days like last night I ate too much chocolate.

I’m down 1.2kgs but feel super bloated all the time. Hoping that goes away soon

Going to stay on 1mg another few weeks at least then try 1.5mg see how that goes

Sometimes it’s hard ro know if I’m just not hungry or is the reta

I’m on 1mg and its working for me. Suppression is there but i could still eat.

 

[308fan]

I am 4 months into it and still at one mg. I don't really want to eat and the cravings are mostly gone. It's hard to get 1500 calories a day because I feel full. Only 20 pounds gone but it's working.

 

[ultima thule]

Yesterday was my 3rd shot of 1mg. I started to feel it basicaly immediately. The day after the first shot I had much less cravings. Actually to reach the proper protein intake is a struggle currently. But on the other hand for the last 3.5 years I'm on the low carb diet, intermittent fasting and eat consistently only 2 meals per day...in a week 1 I've lost around 2kg/4.4lbs...today my wife told me, my face looks different - skinnier. Also my clothes are much less tight fitting, and the belt needs to be fasten tightly...Friday is a weight scale day, so gonna see what's the progress on my weight, if any...