Reta X Cagrilintide

[cgall88]

If I was mixing a 5mg vial of Cagri. What would be the approx split of BAC/AA in volume if I wanted total to be 1ml liquid which would take 10 units a week ie 10 weeks worth. Is it like 75/25 etc. appreciate its trial and error and starting with BAC may need to use my math brain as may not end up with exactly 1ml as I gradually add and test the PH levels. Just curious if it’s around 50/50, 75/25, or 90/10. Appreciate it needs done and tested as I go along but a benchmark would be appreciated please.

2 further questions

would I be better using a 2ml add for a 5mg vial?

Is it a gamble having 1 vial to last 10 weeks or should I just bin half after 5 weeks?

Sorry for war and peace all

 

[gulangaloid]

I would try stacking with sema. Heck, I don't even see a reason why they couldn't even be combined into the same vial so you only have the one injection a week. Admittedly, I have not done that ... I take my sema on Sunday and have the reta on Wednesday. Mixing the two together is a little tempting ... but I like being able to adjust the dosage of them independently.

i (and i think most) would strongly recommend against mixing glps with anything in a vial or syringe

 

[cgall88]

Amateur hour here. I have PH strips and AA ordered and have BAC and just need clarification on what others do please.

Is it the reconstructed final vial that is tested and adjusted to get to the 4ish pH level or is it the mixture of AA/BAC that needs to be at a decent level BEFORE adding to Cagri peptide.

Thanks

 

[MsGizmo]

i (and i think most) would strongly recommend against mixing glps with anything in a vial or syringe

Not that I intend to do this I am curious for your reasoning on that?

 

[Habibibi]

So many chasing appetite suppression when what matters is weight loss. These are not definitely the same thing.

 

[zpped]

Not that I intend to do this I am curious for your reasoning on that?

Incretin Mimetics (what most people refer to as glp1s) are highly reactive with other peptides and cause gelling/aggregation when mixed in solution. This renders them ineffective at best and possibly triggering immunogenic responses.

 

[HughJazz]

I have been thinking about the same thing. I am not quite where you are at though. Reta still gives me appetite suppression. I am also at 6mg weekly, pinning 3mg Sunday and 3mg Wednesday. Wife is at same dose but she regains appetite much quicker after a dose escalation, especially when she is on her period. I was also considering picking up some Cag. I figure a little goes a long way and it acts on different receptor pathways than the Reta. My reasoning is that I can still get the usual beneficial metabolic affects of the triple agonist at current dose and a little appetite suppression as icing on the cake. Well why not just escalate Reta? I am in this for the long haul and once you reach maximum Reta dose, you are done escalating. I figure stacking some Cag can delay dose escalations. Seems like it would be relatively cheaper in the long run, too. Especially because there are two researchers in our household.

 

[narrow11]

Is food suppression similar to Tirz when using Cag? What are the starting protocols for Cag? I usually start slow on all GLPs and increase gradually, so I’m curious to know what others started with and what their experiences have been so far on Cag.

 

[dndgeek]

I take been taking both cag and reta so I have some appetite suppression. I am now on my second week of 4mg of reta (I started at 1mg) and I have just stuck to the 600mcg starting dose of cag but I may up it to 1.2 tomorrow when my shot is due. I would say the 600mcg adds a great deal of self restraint to my eating habits. I think when I take reta up to 6mg a week I will try to discontinue the cagri to see what the base reta is like.

 

[Waclive]

So is there a distinction between the reta not working and just not providing the appetite suppression?

With better eating habits and strength training, could reta still have the benefits of the 2 other agonist even if the appetite suppression isn't an issue?

 

[zpped]

So is there a distinction between the reta not working and just not providing the appetite suppression?

With better eating habits and strength training, could reta still have the benefits of the 2 other agonist even if the appetite suppression isn't an issue?

Yes there is a distinction. Appetite and Satiety are separate functions. I get hungry and then I get full.

 

[Waclive]

Yes there is a distinction. Appetite and Satiety are separate functions. I get hungry and then I get full.

I understand they're two separate functions in the body.

I'm asking if the people saying it doesn't work is saying that based solely on the presence of food noise or if it's actually working by causing insulin sensitivity and losing body fat but not suppressing food noise.

 

[cygnus]

So is there a distinction between the reta not working and just not providing the appetite suppression?

With better eating habits and strength training, could reta still have the benefits of the 2 other agonist even if the appetite suppression isn't an issue?

Improved insulin sensitivity, nutrient partitioning, and signal for hepatic fat burn would still happen absent the "hunger" signal associated primarily with GLP-1 and thus still be working.

Cagri hitting on Amylin does make me think that Eli, Novo, or Pfizer will probably end up making a quad agonist that covers GLP-1/GIP/Glucagon/Amylin as it seems like a no-brainer given CagriSema is going to fare well and some of the vendors starting to mix reta and cagri.

CN vendors, figure out an oral MK677/orforglipron combo.

 

[Waclive]

Improved insulin sensitivity, nutrient partitioning, and signal for hepatic fat burn would still happen absent the "hunger" signal associated primarily with GLP-1 and thus still be working.

Cagri hitting on Amylin does make me think that Eli, Novo, or Pfizer will probably end up making a quad agonist that covers GLP-1/GIP/Glucagon/Amylin as it seems like a no-brainer given CagriSema is going to fare well and some of the vendors starting to mix reta and cagri.

CN vendors, figure out an oral MK677/orforglipron combo.

Thank you. That is exactly what I was looking for!

 

[Nextlevel 23099]

I'll spout my typical "be careful of the pH level of cagri" schpeil. Don't just mix it with BAC and get the pH down to 4 ideally, or within 3.5-4.5.

How do you test the PH levels and get it higher or lower as needed? I have been losing weight with Reta 3mg (started at 1mg, then 2mg and now 3mg as I am slow rolling it) but I've heard a little cagri with reta goes a long way.

 

[CNCCurrency]

How do you test the PH levels and get it higher or lower as needed? I have been losing weight with Reta 3mg (started at 1mg, then 2mg and now 3mg as I am slow rolling it) but I've heard a little cagri with reta goes a long way.

At pH 7.4 (closer to physiological pH), cagrilintide degrades much faster, with one study showing nearly 45% degradation in 10 days compared to minimal degradation for a newer analog.

Improved Analogs: Researchers are developing next-generation amylin analogs, like the related Compound C, which show superior stability at pH 7.4, allowing for potential co-formulation with GLP-1 drugs.

 

[thatkatmat]

Amateur hour here. I have PH strips and AA ordered and have BAC and just need clarification on what others do please.

Is it the reconstructed final vial that is tested and adjusted to get to the 4ish pH level or is it the mixture of AA/BAC that needs to be at a decent level BEFORE adding to Cagri peptide.

Thanks

I think it's the Bac/AA mixture...Anyone care to chime in?

 

[RadicalCrimson]

I think it's the Bac/AA mixture...Anyone care to chime in?

Some people have reported a 4pH reconstituted Cagri with just BAC water (pre-buffered), so IMO you should definitely test that first before adding anything.

 

[StraightCancer]

You will hear different things from different people. This is my experience I have been

experimenting with tirezepatide for almost 15 months and up to 12.5 mgs. I switched to

Reta and started at 5 mgs and had almost no appetite suppression for over a month. I moved up to 7 mgs and had a little suppression so I added .5mgs of cagri and wow

what a difference. Be careful with cagri it’s a very strong suppressant. If you over do it

you aren’t gonna like the feeling. All in all I have lost 108 pounds since I started. This

is my experience take from it what you will. I also know people that are using Reta and

tirz together .

Thank you for this.

Just an update for everyone, I hit a weight plateau after losing 70lbs in 3 months so I decided to take a break from Reta and get my metabolism back to normal.

I have only rebounded about 7lbs in the last 3-4 weeks since I have been off Reta which is healthy if anything.

That being said, I do plan on buying 10mg cagri to add to a stack or use on its own for purely appetite suppression in the future.

 

[Wallydog]

I'll spout my typical "be careful of the pH level of cagri" schpeil. Don't just mix it with BAC and get the pH down to 4 ideally, or within 3.5-4.5.

I know this is an old thread and post but can you expand on the pH issue with Cagri? I've used it before to jump start stalled weight loss when using 15mg tirz and didn't notice anything unusual with the solubility or the injection. Actually helped move some pounds off. Thanks.