Reta Question: how old is too old?

[HistLady]

By someone you know?

Not directly. A friend of a friend.

 

[SVT810E]

I know it's not Reta, but this reconstituted Tirz testing was done last month.

I would probably not put too much stock into testing conducted by AFI. Thankfully other testing done by more reputable labs in the past actually shows much better results than this for tirz.

The problem is that reta is very much not tirz and degrades much more rapidly. The real concern is not a loss of potency. If that was all you could run a vial until it wasn’t hitting right, heck you could bump your dose up at that point. The issue is that the degraded peptide can piss off your immune system. It’s a bad idea to train your immune system to get aggro against a drug a lot of you are hoping to take for years. There are a lot of ways that could go sideways for you.

You might see hypersensitivity reactions like ISRs or even full blown drug allergies. That already happens with the normal peptide, the impurities just increase your risk of it an unknown amount. You might develop anti-drug antibodies that attack the drug (or even similar drugs). That would manifest as “the drug doesn’t work anymore”. Not fun.

A lot of people in this thread seem to think the issue is a loss of potency, and that’s not it at all. From a harm reduction perspective this “I did it and nothing bad has happened yet” bravado is terrible. I’d be surprised if reckless practices like these don’t end badly for some members of our community. In fairness you’ll probably get lucky and save $3/month without any consequences. Really worth the gamble?

 

[RetCurious]

I would probably not put too much stock into testing conducted by AFI.

or Peptide Critic. He had a couple of good educational videos and then fell off into chasing clicks undermining any good he had accomplished.

 

[nitetrak]

Before gray I bought from compounding pharmacies. I'd normally get a 90 day supply and each vial had an expiration date of 90 days from compounding. I don't understand why some people say 28 days. One time I got a six month supply (of either sema or tirz, I don't remember.) Yes, I know reta has been tested to degrade faster, but that's it, degrade.

So I used a vial reconstuted 6 months before (by a compounding pharmacy.) It was clear so I used it.

Compounding pharmacies are way more sterile than what us gray people do, so there is that.

If it's still sterile, I'd say no problem going as long as it takes, maybe just add a bit more.

I've seen the results of culture testing and I wonder what kind of sterile conditions the vial was in.

So, I'm on the side of "if it's still clear, it possibly may still be good" (but I'm cheap and don't want to waste it.)

 

[Blueeyedme]

Before gray I bought from compounding pharmacies. I'd normally get a 90 day supply and each vial had an expiration date of 90 days from compounding. I don't understand why some people say 28 days. One time I got a six month supply (of either sema or tirz, I don't remember.) Yes, I know reta has been tested to degrade faster, but that's it, degrade.

So I used a vial reconstuted 6 months before (by a compounding pharmacy.) It was clear so I used it.

Compounding pharmacies are way more sterile than what us gray people do, so there is that.

If it's still sterile, I'd say no problem going as long as it takes, maybe just add a bit more.

I've seen the results of culture testing and I wonder what kind of sterile conditions the vial was in.

So, I'm on the side of "if it's still clear, it possibly may still be good" (but I'm cheap and don't want to waste it.)

The 503A/B compounders are a whole different thing with 503B having tested stability (I assume with some sort of preservative) out to one year - hence their long BUD date...but again, we're not talking Reta. Regarding the 28 day rule once those sealed vials have been pierced...that's all about sterility of introducing air and whatnot every time you draw from the vial. Many are comfortable going well beyond the 28 days with 503A/B as long as it's crystal clear. For self-reconstituted grey, 28 days is 5 draws...maybe stretch out a couple of weeks to 7 draws...but that's about as far as I personally want to take it.

 

[jsc1980]

Regarding the 28 day rule once those sealed vials have been pierced...that's all about sterility of introducing air and whatnot every time you draw from the vial.

What are people's thoughts on filtering into a pen cartridge and priming to remove air in terms of longer stability? Curious if a study has been done (or a study using a reconned vial under vacuum). If the puncturing and introducing air is one of the issues that causes degradation and/or lowering of sterility, in theory, if you minimize those factors you minimize the loss as well. If I vacuum seal food, it says good longer; would the same apply to a peptide?

 

[Elgordoboy]

I’m using a 30mg bottle I started on at the end of January. I just moved up to 2mg (if it was full strength) and when I finish this one I have some 15’s to start in on. I’ll start off at 1mg with those and see how it goes for the day and pin more the following day if needed. I need to have a reason to throw something out and so far I haven’t been given one in my actual use

 

[SVT810E]

The 503A/B compounders are a whole different thing with 503B having tested stability (I assume with some sort of preservative) out to one year - hence their long BUD date...but again, we're not talking Reta. Regarding the 28 day rule once those sealed vials have been pierced...that's all about sterility of introducing air and whatnot every time you draw from the vial. Many are comfortable going well beyond the 28 days with 503A/B as long as it's crystal clear. For self-reconstituted grey, 28 days is 5 draws...maybe stretch out a couple of weeks to 7 draws...but that's about as far as I personally want to take it.

The compounding pharmacies are also selling tirzepatide which holds up very well for months with negligible degradation in tests of both their products and gray market tirz.

Reta is different than tirz. Do you see any 503b pharmacies saying that their reta is good for months?

 

[JA$$E]

5-6 weeks max using a insulin pen for delivery. Then toss it.

 

[Habibibi]

Using a pen cartridge that was reconstituted back in january, and stored in the refrigerator. By some miracle, I'm still losing weight. These peptides are sturdier than people think.

 

[Blueeyedme]

The compounding pharmacies are also selling tirzepatide which holds up very well for months with negligible degradation in tests of both their products and gray market tirz.

Reta is different than tirz. Do you see any 503b pharmacies saying that their reta is good for months?

1. I guess you missed the part where I said we’re NOT talking Reta. 2. Of course there are no 503A/B pharmacies compounding Reta…is that a serious question? 3. Degradation data on both Tirz and Rita is out there from Jano and another source which I’ve seen on this forum.

 

[TooBigtoFail]

Based on janoshik testing, degradation is barely 1% a month. I use it up to 60 days if the bac was fresh. When in doubt, filter it. GLP1 peps are quite resistant. I am more concerned about bacterial growth after 90 days.

 

[CNCCurrency]

Using a pen cartridge that was reconstituted back in january, and stored in the refrigerator. By some miracle, I'm still losing weight. These peptides are sturdier than people think.

Especially tirz

 

[CNCCurrency]

Based on janoshik testing, degradation is barely 1% a month. I use it up to 60 days if the bac was fresh. When in doubt, filter it. GLP1 peps are quite resistant. I am more concerned about bacterial growth after 90 days.

Tirz gets stronger after 90 days