Reta Question: how old is too old?

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HistLady

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I have a vial of reta 30 that was reconstituted 10 weeks ago and has sat in the refrigerator undisturbed for all that time. It is crystal clear--no floaters, etc. Would you still use it?
 
HistLady said:
I have a vial of reta 30 that was reconstituted 10 weeks ago and has sat in the refrigerator undisturbed for all that time. It is crystal clear--no floaters, etc. Would you still use it?
Yes
 
No one can tell you how much active Reta remains after 10 weeks. Based on the results of some experiments, it is more likely between 40% and 60%. The problem is not so much the loss of activity, but rather that no one knows what the degradation products consist of, what their biological effects are, or whether they are capable of triggering an immune response.

It is unlikely that bacterial contamination significant enough to form a biofilm has occurred. This depends on whether you followed proper aseptic techniques during reconstitution.

Keep in mind that none of this will be visible to the naked eye.

A quick and simple test is to check the pH by placing one or two drops on a test strip. If the pH is below 5 or above 8, you can discard it. Around 5.5 - 6, it’s worth a try.

If I were to try it, I’d start with a small dose of a few units (less than 0.05 ml, or 5 u) to check for any reaction at the injection site within 24 hours. If that’s okay, gradually increase to a higher dose. Keep a phone nearby to call emergency services, or better yet, someone with an EpiPen.

But since I pay between $15 and $30 for my vials depending on the quantity, I wouldn’t risk my life for so little.
 
It probably looks fine, but like mentioned above you dont know the true degradation without testing. I'm more on the careful side of things and probably wouldn't without doing something similar to what eidos mentioned above.
 
eidos said:
No one can tell you how much active Reta remains after 10 weeks. Based on the results of some experiments, it is more likely between 40% and 60%. The problem is not so much the loss of activity, but rather that no one knows what the degradation products consist of, what their biological effects are, or whether they are capable of triggering an immune response.

It is unlikely that bacterial contamination significant enough to form a biofilm has occurred. This depends on whether you followed proper aseptic techniques during reconstitution.

Keep in mind that none of this will be visible to the naked eye.

A quick and simple test is to check the pH by placing one or two drops on a test strip. If the pH is below 5 or above 8, you can discard it. Around 5.5 - 6, it’s worth a try.

If I were to try it, I’d start with a small dose of a few units (less than 0.05 ml, or 5 u) to check for any reaction at the injection site within 24 hours. If that’s okay, gradually increase to a higher dose. Keep a phone nearby to call emergency services, or better yet, someone with an EpiPen.

But since I pay between $15 and $30 for my vials depending on the quantity, I wouldn’t risk my life for so little.
I really appreciate the detailed reply. My instinct is to get rid of it and you just confirmed it.
 
Yeah, I totally read the thread title as a question about us Geezers.🤣 I was prepared to defend the no age limit for glp line!
 
spanky2026 said:
Yeah, I totally read the thread title as a question about us Geezers.🤣 I was prepared to defend the no age limit for glp line!
As a geezer-in-training, I would never!
 
spanky2026 said:
Yeah, I totally read the thread title as a question about us Geezers.🤣 I was prepared to defend the no age limit for glp line!
haha, me too!

Honestly, I'd prob still give it a try at 10 weeks.
 
I had some that was 11 weeks old in my possession. Not sure how long it was reconstituted before I received it. I started to doubt that it was working like it should. I reconstituted a new vial and could immediately tell that the new one was working as it should. I started questioning whether or not it was working around week nine.
 
HistLady said:
I have a vial of reta 30 that was reconstituted 10 weeks ago and has sat in the refrigerator undisturbed for all that time. It is crystal clear--no floaters, etc. Would you still use it?
Yes though probably degraded about 10 to 15 percent. Just adjust dose for the degradation.
 
BNLFL said:
10 weeks is generally my limit. Had I reconstituted it, I likely use it. It also depends how big the vial is.
It was given to me reconstituted so I doubt it was filtered or anything. I keep looking at it but will probably get rid of it.
 
HistLady said:
It was given to me reconstituted so I doubt it was filtered or anything. I keep looking at it but will probably get rid of it.
By someone you know?
 
If it was reconstituted with Bac, filtered and refrigerated it's worst case scenario is around 10% degradation.

I'm following some testing that shows 0 sterility issues out past 90 days under these conditions.
 
I know it's not Reta, but this reconstituted Tirz testing was done last month.
 
It is most likely fine because I think these peptides are more durable than they seem or appear to be. Again, this is all like experimental things that everyone is doing, but based on the anecdotal evidence I've read on Reddit and these forums and videos, peptides aren't as fragile as we think they are. As long as it looks good, it most likely is.
 
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