Reta OD

[ghreid]

https://www.acpjournals.org/doi/10.7326/aimcc.2025.1218.

First reported case on reta overdose. Patient got from online med clinic and had starting dose of 10mg weekly. this was increased to 20mg. Patient forgot that he had taken his dose already and administered a second dose. within 4 hours developed intractable diarrhea (total 40mg reta). He took otc anti-diarrhea meds without response. On 7th day was admitted to hospital due to severe dehydration and early kidney failure. These were reversed with hydration and K+ replacement. Discharged after 3 days. I even get diarrhea from the 10mg dose!

 

[SeaGypsy]

20mg? I thought max dose was 15mg. I couldn't pull up the article, it said not found

 

[toologic]

20mg? I thought max dose was 15mg. I couldn't pull up the article, it said not found

take the period off the end of the link

 

[retarequired]

20mg? I thought max dose was 15mg. I couldn't pull up the article, it said not found

https://www.acpjournals.org/doi/10.7326/aimcc.2025.1218

It's the dot in OP's link lol

 

[SeaGypsy]

https://www.acpjournals.org/doi/10.7326/aimcc.2025.1218

It's the dot in OP's link lol

Got it, thanks

 

[5byfive]

Just missed the Darwin Award.

 

[V6R3W]

I'm curious whether he intended to take 10mg/20mg, or made a mistake reconstituting.

 

[ambot88]

I mean... they seem way too oblivious to be self administering meds.

 

[Chili777]

You don't need to read a medical journal. Reddit is filled with them. Some guy took 20 mg just this week. They always Reddit, "Should I go the the hospital?".

 

[V6R3W]

20mg? I thought max dose was 15mg. I couldn't pull up the article, it said not found

Highest dose tested in phase 2 and completed-thus-far phase 3 trials has been 12mg

 

[CandyCap]

This is why we can't have nice things.

 

[NIGLP89user]

From reading the article, it sounds like he actually started at 10mg. Decided to bump it up to 20 and then took another 20 by accident.

Reddit is full of people who do 0 research yet somehow manage to navigate their way around ordering and receiving peps.

 

[CJsMom]

https://www.acpjournals.org/doi/10.7326/aimcc.2025.1218.

First reported case on reta overdose. Patient got from online med clinic and had starting dose of 10mg weekly. this was increased to 20mg. Patient forgot that he had taken his dose already and administered a second dose. within 4 hours developed intractable diarrhea (total 40mg reta). He took otc anti-diarrhea meds without response. On 7th day was admitted to hospital due to severe dehydration and early kidney failure. These were reversed with hydration and K+ replacement. Discharged after 3 days. I even get diarrhea from the 10mg dose!

Good article - thanks!

 

[toologic]

I've heard of doctors mixing up sema and tirz. Started a patient using sema at 2.5 instead of .25 and the pharmacy didn't catch it . Mistakes happen but we only hear about them blasted all over the news if its grey when this can happen with any drug. Drinking too much water can harm you too.

 

[JoonyO]

SMH.

 

[ghreid]

I've heard of doctors mixing up sema and tirz. Started a patient using sema at 2.5 instead of .25 and the pharmacy didn't catch it . Mistakes happen but we only hear about them blasted all over the news if its grey when this can happen with any drug. Drinking too much water can harm you too.

being a MD myself I know this is true. Was on call for another physician who had rx'd an antihistamine for a patient, the npatient called an said it wasn't helping his allergy so the doc told him to take 2. again said he felt worse so was told to take an additional dose in the afternoon. when I saw him he looked awful and was having a hard time getting a BP on him. He had brought his meds with him, I noticed that the pills were not antihistamines. the pharmacy had switch it to a strong blood pressure pill. I posted this to remind people to be vigilant of their doses. luckily the diarrhea was the only major side effect noted at supra-physiologic doses of the Reta. I myself have had times where I couldn't remember if I had pinned Reta that day along with my other peptides so skipped it just in case.

 

[Nopenada]

I had a bad day on 1.5mg. Highest I was able to comfortably get was 1mg twice a week. I have a friend I just started on Reta a couple of weeks ago and she’s getting a good amount of apatite suppression on 1mg twice a week so doesn’t need to go up either. Nobody should be starting at double digits with this stuff.

I read Lilly is admitting to incidents of super-responders but called it “very rare”. I call BS on that.

 

[ThatNextGril]

[EDIT] re: people not confirming their meds or doses.

JFC, people really need to take their own agency when it comes to their own (and only!) body. Sheesh. The amount of times I see/read about people mindlessly doing things - or taking things, in particular - without confirming they know what it is, is really beyond my ken. Like, sure, I can make a case for the very elderly or very young - ideally they should be having someone advocate for them and be their eyes and ears - but when the person is of independent age and is in charge of their own health, c'mon. SMH.

 

[mainefungi]

https://www.acpjournals.org/doi/10.7326/aimcc.2025.1218.

First reported case on reta overdose. Patient got from online med clinic and had starting dose of 10mg weekly. this was increased to 20mg. Patient forgot that he had taken his dose already and administered a second dose. within 4 hours developed intractable diarrhea (total 40mg reta). He took otc anti-diarrhea meds without response. On 7th day was admitted to hospital due to severe dehydration and early kidney failure. These were reversed with hydration and K+ replacement. Discharged after 3 days. I even get diarrhea from the 10mg dose!

Did you read it? It says “He started on a self-determined dose of 10 mg subcutaneously weekly for several weeks and had only just increased the dose to 20 mg”

Self determined… he didn’t get it from a clinic. A clinic would have given dosing instructions. Sounds to me like he decided a vial was a dose.

 

[ThatNextGril]

Did you read it? It says “He started on a self-determined dose of 10 mg subcutaneously weekly for several weeks and had only just increased the dose to 20 mg”

Self determined… he didn’t get it from a clinic. A clinic would have given dosing instructions. Sounds to me like he decided a vial was a dose.

Oh I know, I wasn't specifically noting that post. More the follow up anecdotal ones.