我服用瑞达（Reta）大约两个月了，效果立竿见影。当时我每天服用4毫克，食欲和对食物的渴望都消失了，而且饱腹感持续时间更长。但最近两周，我发现吃得多了才觉得饱，体重也停滞不前了。我服用的瑞达是60毫克一瓶，用3毫升巴氏杀菌液溶解。我已经把剂量增加到5.5毫克，但最近两周感觉没有任何变化。会不会是我的瑞达药效降低了？
Reta耐受性或退化？
- Thread starter RamCummins6.7
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我之前用6毫克的时候也出现过这种情况，后来加到7毫克，就没事了。上周五刚用了8毫克，又有了之前那种Reta的感觉，体重也减轻了。新买了一瓶R50。之前用6-7毫克的剂量用了6周。如果你把3毫升苯扎氯铵混入60毫克的R50里，而你的剂量是5.5毫克，那你是不是相当于注射了28单位/2.8毫克？
是的，我用PeptideCalc肽计算器来确保我抽取的剂量正确。强迫症让我很焦虑。这8毫克是从同一瓶里抽出来的，还是你从新瓶里抽出来的？BNLFL said:
这样我就放心多了，看来可能不只是我一个人这样。
两瓶新的MLB R50。混合了3毫升BAC，用4.2毫升针头注射，得到8毫克的剂量。我们用完了所有的R40。我每次用两瓶，最多用到R60。我妻子也在用。RamCummins6.7 said:
Yeah I very quickly adjusted or something and reta lost effectiveness pretty quickly for me, even at 8-10 mg doses. Pretty strange, since in the beginning it was super effective even at low doses. But it was like once my body decided to not respond, dosage didn't matter much anymore.RamCummins6.7 said:
This is exactly what happened with me too. It was very crazy, everything was working EXTREMELY well for three months and then it was like a light switch flipped off. After that switch, even bumping up to 12 mg weekly didn't help.Hawk_recon said:
I'm taking a 6 week break from reta (it's been 21 days so far) to see if that "resets" things for me, and plan to report back here.
Yeah it's so weird! Please do report back because I'd be curious to hear if that does in fact reset things for you.bluefootedboobie said:
We know that Tirzepatide is very stable reconstituted and refrigerated to about 60 days and starts dropping after that. We also think that Retatrutide likely to be less stable. I would not be shocked to starting seeing degradation around the 6o day mark. Might be worth trying a fresh vial to see if there is a difference. I'm sure everyone would be interested in the results.
It's a good point. I tried new vials and even ones from different vendors just in case. For me the result was the same - seemingly little to no effect5byfive said:
Got it. I'm going to recon the fresh vialBNLFL said:
Of r60 and pin that and see. My wife is just going to start reta, switching from sema. i want to start her on a fresh vial too.
yea, very weird. I only have one brand to compare to. I have a 10mg kit coming tomorrow that I may just recon and use right away and sheep if that’s the issue or just meHawk_recon said:
How much are you going to start her on, and what size vial are you going to mix?RamCummins6.7 said:
10mg vial with 2ml BAC and .5mg-1mg. She was on sema and is still on tesa. I don’t want to start her too high and is crushes her but at the same time I’m reading since she’s already on a glp1 she may not initially get anything out of that low of a dose.
BNLFL said:
Same exact problem. Bumped up to 6mg last 2 weeks ago? Had some weird sides so i dropped back to 4. Been raising calories and lowering them and if anything been gaining weight every day. Usually see a 2 to 4 pound raise from morning to night. Now im swinging like 5 to 6. Drink a gallon of water a day. Under 2500c in deficit too regularly. Over 150g minimum of protein. Gym of heavy weight training 5 days a week.Nothing. no budge. At lowest 269 then keep bouncing around 270 to 275. its so bizarre
The thing is that we do see significant degradation sometimes occurring even before the 60 day mark with reta, it’s not as hardy as tirz, but there’s a difference between “purity low enough this isn’t ideally safe for human consumption” and “purity so low that it causes a loss of drug effect”. The degradation we see is generally the former, excluding big sterility failures (which shouldn’t happen in two months with good bac).5byfive said:
Yes, im consistently under my 2400 cal threshold while still hitting my protein and carbs. I train hard 4 days a week and hit my cardio on my active rest days, yet my weight has stalled. I just got a new kit in probably going to give it a shot and see.quicksilver80 said:
Yea, I’ve read this too which is why I’m wondering. This vial is from a site that i ordered from before i started sourcing for myself overseas. It was also reconstituted with Hospira. Like i said above I’m going to use the new 10mg vials i got in and see if they are more potent thay the 60mg now is.SVT810E said:
It's interesting to see a lot of people chiming in with similar experiences. I'm currently on 6mg and there is absolutely zero appetite suppression, and I haven't really lost any weight during this entire journey.. though there's been some recomp since I added gh. The past month has been quite difficult as reta seems to increase my appetite - if left to my own devices, I can eat an entire cake in one sitting. My vial is fresh, m/p/e tested and filtered.
Yea i took 7mg this week and i still get full fast but i also get hungry fast, nothing like that first 4mg dose lol.miameow said:
Which i wouldn’t mind so much but the fact I’m in a deficit and my weight stalled is what has me wondering if it’s just not working. At 4mg i felt like i had more energy and didn’t get crashes during the day and I’m not getting all the Reta benefits. Or it is just in my head lolmiameow said:
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