Reta making me extremely hungry

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guster

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Hey guys, little context.

Last year I used Mounjaro for 8 months. I started at 1 mg for one month, then 2.5 mg the second month, 5 mg for four months, 7.5 mg for one month and 10 mg for two weeks. I lost 30 kg. I never had the dramatic hunger suppression people talk about, but it made it much easier to say no, especially in the evenings.

I have been off for about a month and a half and recently started retatrutide.

I originally wanted 30 mg because of a New Year deal, but that was sold out so I received 40 mg instead. I first added 2 ml bacteriostatic water to the vial, drew out 1 mg, filtered it into a pen cartridge, then added another 2 ml of bac water through a filter into the same cartridge. So in total that should be 20 mg in 3 ml. During priming and some leaking I seem to have lost almost 1 ml, but the concentration should still be the same.

To start cautiously, I took 0.5 mg on Monday. On Wednesday I added another 0.5 mg. The next Monday I took 1 mg because I felt nothing, and that Wednesday I added another 1 mg.

Instead of reducing my hunger, it is making it worse. I have not been this hungry in a long time. I keep eating. Even after a balanced dinner with protein, rice and vegetables, I go straight to the fridge and eat more. I am suddenly craving sugary drinks and candy, which I normally do not even like.

Is this normal when starting retatrutide?

Only taking reta atm.

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You were taking 10mg of Tirz for months, are now taking 1mg twice a week, and you wonder why you’re hungry…

Your reconstitution method is curious, and I assume has a typo.
 
woundcarping said:
You were taking 10mg of Tirz for months, are now taking 1mg twice a week, and you wonder why you’re hungry…

Your reconstitution method is curious, and I assume has a typo.
Yes, I understand. During the almost two months I was off tirzepatide, I felt fine. However, right now I am actually experiencing more hunger than I did before ever starting a GLP medication.

My mixing process may seem unusual because I accidentally purchased a higher concentration than intended, 40 mg per vial. To avoid wasting product, I reconstituted and used only half, which equals 20 mg, and stored the remaining half in the freezer for later use.
 
40mg Reta and 4ml Bac is what I do. I started at 2mg and it really cut my appetite back big time from the get go.
 
Recency bias is a thing, it seems unusual that Reta would increase your hunger signaling by itself.

What is your weight doing?

How are your sides?

What are you trying to accomplish/what are your goals?

Why the switch to Reta from Tirz?

The easy answer could be to push more Reta and see what happens.
 
guster said:
Yes, I understand. During the almost two months I was off tirzepatide, I felt fine. However, right now I am actually experiencing more hunger than I did before ever starting a GLP medication.

My mixing process may seem unusual because I accidentally purchased a higher concentration than intended, 40 mg per vial. To avoid wasting product, I reconstituted and used only half, which equals 20 mg, and stored the remaining half in the freezer for later use.
Out of interest, I'm keen to know if you feel if the reconstituted Reta degraded after spending time in the freezer?
 
woundcarping said:
Recency bias is a thing, it seems unusual that Reta would increase your hunger signaling by itself.

What is your weight doing?

How are your sides?

What are you trying to accomplish/what are your goals?

Why the switch to Reta from Tirz?

The easy answer could be to push more Reta and see what happens.
I went from 105 kg to an unhealthy 78 kg . after Christmasand During my Japan trip I gained back to 85 kg. I had zero side effects. I also never experienced side effects on tirzepatide.

I dropped from 32 percent body fat to 18 percent. My goal is to get under 15 percent. I switched to retatrutide because Mounjaro was costing me 600 euros per month.

I swim four times a week, go to the gym four times a week, play tennis, and ride my bike regularly.

I think I am going to move up to 4 mg.
 
I have read that hunger suppression on reta kicks in around 8 mg. Tried it myself for a few months and switched back to T. I liked R but wasn't losing, which was fine, I actually was trying to stop losing. (Feels batshit to type that! I wanted to stop losing! WTaF!) But R does not have the inflammation suppression that T does, and I need that.
 
Graymaxxem said:
I have read that hunger suppression on reta kicks in around 8 mg. Tried it myself for a few months and switched back to T. I liked R but wasn't losing, which was fine, I actually was trying to stop losing. (Feels batshit to type that! I wanted to stop losing! WTaF!) But R does not have the inflammation suppression that T does, and I need that.
Ah ok, I was hoping that the third fat-burning mechanism of retatrutide would be a real game changer. I’m going to try it for a while and see how it goes. Part of me is wondering whether my batch might be bunk, because with Mounjaro, even at 1 mg, I at least felt something.
 
guster said:
Im not using the frozen reta. But the other half
Doh ! That makes complete sense, when you get to it I'm keen to know. Research papers say it does not work so well after reconstitution then frozen. Some lab rats on the inter web say it degrades slightly . My lab rat will know the answer in a few months. I'll share experience on a separate post at that time , great to hear your experience too.
 
guster said:
Ah ok, I was hoping that the third fat-burning mechanism of retatrutide would be a real game changer. I’m going to try it for a while and see how it goes. Part of me is wondering whether my batch might be bunk, because with Mounjaro, even at 1 mg, I at least felt something.
From what I've read the third receptor does not effectively kick in until +6mg , however others report less. I'm only at 3 this month , moving to 4 next month I expect
 
Sid the SeaGull said:
From what I've read the third receptor does not effectively kick in until +6mg , however others report less. I'm only at 3 this month , moving to 4 next month I expect
dam thats a long time if you take the normal route. I’m planning to move up to 4 mg in week three. I suspect my previous tirzepatide use may have created some level of tolerance, but we’ll find out.
 
guster said:
Im not using the frozen reta. But the other half
Do not freeze reconstituted retatrutide. Use the whole vial, reconstituted retatrutide doesn't suffer any substantial degradation, even at 60 days. I highly recommend you filter, since the main risk of using it past 4 weeks is bacterial growth.
 
guster said:
dam thats a long time if you take the normal route. I’m planning to move up to 4 mg in week three. I suspect my previous tirzepatide use may have created some level of tolerance, but we’ll find out.
It takes your body a month to reach full potency in your body. If you’re increasing every 3 weeks you aren’t allowing it to reach full potency. Going by “feels” is a great way to get in trouble. Give it time to work.
 
FlowerFairy said:
It takes your body a month to reach full potency in your body. If you’re increasing every 3 weeks you aren’t allowing it to reach full potency. Going by “feels” is a great way to get in trouble. Give it time to work.
And you dont think my body is used to glp thanks to mounjaro?
 
FlowerFairy said:
It does not change the way these drugs work. It has nothing to do with your body getting “used to” glp drugs. It is the way they work in everyone. 🙄
Yeah I get that’s how it’s supposed to work, but not everyone reacts the same. Some people feel something at 0.5 mg, others don’t notice anything until they’re at 8 mg and a few months in. Ill update when im at 4
 
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