One area where tolerance is a real thing with GLP drugs is nausea and vomiting and slowed gastric emptying, so it is possible over 8 weeks to have lost some tolerance. Depends a bit also on what side effects you had when previously increasing doses of tirz.
The lowest risk method is obviously to start at low doses and gradually build back up. If you want to increase doses more rapidly than standard, the safest way to do it is with smaller more frequent doses. That way each peak in blood levels will be lower, and it will only take 2 or 3 days for blood levels to drop back to pre dose levels, so twice a week or second day dosing. 2.5mg twice a week as a restarting dose is less likely to cause problematic side effects than 5mg once a week. This also enables small increases in dose more often, so 2.5 to 3.5 mg twice a week in a week or two , but if you do start getting side effects it is important to slow down or stop increases in dose until things settle. once you get to the weekly dose you want you can gradually increase one half of the doses while decreasing the other half until you get back to once a week. But you need to check out glp plotter before doing this so you understand the drug pharmacokinetics, and doing this without previously being on GLP drugs is not such a great idea. I used this process to get from 1mg to 15mg/week in a month when I swapped from semaglutide to tirz. In general the faster you push dose increases the higher the chance of unpleasant side effects.
