Peptides and cholesterol

[Turbo-Farmer]

It's ridiculous how often someone has to have a heart attack before they actually treat FH.

I’m of the same mind, people live into their 90’s in my family and I don’t know any of them that died of heart disease. High cholesterol is something that everyone has, I tried resuvastatin (Crestor) for a brief period of time and felt so off that it wasn’t worth it to me anymore. I had a hard time running with the fatigue and cramping. But when I found out that it may actually increase your blood sugar levels and contribute to insulin resistance I quit. I was working to reverse my diabetes and it wasn’t helping. My LDL and Triglyceride profiles have improved slightly since I started tirzepitide.

I have hope that a Glp (peptide) will help me the way Tirz did for my weight and blood sugar.

 

[Dogmandu]

I just started reta. Unfortunately it's not going to be enough of a drop for me even if I get the best results seen in the study. With me having FH and a high lifetime LDL I should be aiming for under 90 LDL and ideally 70.

Currently at 255 LDL, 23 HDL, hs-CRP 12, ApoB 183. I actually had worse cholesterol numbers when I was a 21 year old active and fit soldier eating a healthy diet so in my case it's genetics.

I just started Repatha(paying out of pocket $240 a month ) and ezetimibe. Whatever reta brings to the table will be welcomed though. I could use every little bit.

Repatha at $240 per month is still insane, but last time I checked it was about $600 out of pocket. At least it's moving in the right direction.

 

[CNCCurrency]

I’m of the same mind, people live into their 90’s in my family and I don’t know any of them that died of heart disease. High cholesterol is something that everyone has, I tried resuvastatin (Crestor) for a brief period of time and felt so off that it wasn’t worth it to me anymore. I had a hard time running with the fatigue and cramping. But when I found out that it may actually increase your blood sugar levels and contribute to insulin resistance I quit. I was working to reverse my diabetes and it wasn’t helping. My LDL and Triglyceride profiles have improved slightly since I started tirzepitide.

I have hope that a Glp (peptide) will help me the way Tirz did for my weight and blood sugar.

Eight months in and my a1c went from 6.3 to 5.1 and all my other labs have improved significantly. My doctor was in shock and looked at me in amazement and said how?

 

[CathyGoesFar]

Repatha at $240 per month is still insane, but last time I checked it was about $600 out of pocket. At least it's moving in the right direction.

The patent expires in 2028 and the FDA has already rejected some of their maneuvering to try to extend it. We could be looking at a generic version in just a few years.

 

[Habibibi]

It's ridiculous how often someone has to have a heart attack before they actually treat FH.

I'm going to push hard at my next appointment to get FH added to my conditions lists and request to see a lipid specialist. So far they have all acknowledged that I have it but continue to list "hyperlipidemia, unspecified" . I firmly meet diagnostic criteria.

I have always refused statins and then they end the conversation at that. No doctor has ever offered me other options. Pretty much "You don't want statins? Ok, F off and die". I have met people with permanent damage from statins so as long as other options exist I'm not doing it. It generally requires high doses or multiple types of statins to adequately lower LDL in FH and that means an increased risk of side effects. Repatha and ezetimibe are so far side effect free although trying to use the auto injector is such a PITA I'll probably pull it apart and self inject.

Old statins require high doses, new ones don't. 10mg rosuvastatin is enough to elicit up to 45% decrease in ldl. A good pcp will start you at 5mg, and won't even go over 10mg if you need more decrease. They will instead prescribe Ezetimibe and that will further reduce ldl levels to 70%.

 

[CathyGoesFar]

Old statins require high doses, new ones don't. 10mg rosuvastatin is enough to elicit up to 45% decrease in ldl. A good pcp will start you at 5mg, and won't even go over 10mg if you need more decrease. They will instead prescribe Ezetimibe and that will further reduce ldl levels to 70%.

A good pcp is what I'm lacking. Mine sent me 10mg Atorvastatin even after I listed muscle side effects as one of my biggest reasons for refusing statins. I'm guessing it's cheaper. After that I just went to telehealths and got what I wanted prescribed. It's not like I wasn't a good candidate for repatha and ezetimibe anyway.

 

[lessthanhalf]

Have you taken statins and experienced muscle pain?, or you are concerned about it happening if you do take them? Given the risks involved with familial hyperlipidemia, not taking statins for a possible risk sounds somewhat extreme, not taking them due to having unacceptable side effects is a very different story , and I would assume and hope most doctors would try to treat the problem in that case, rather than just end the conversation. It is not rare at all.

I would imagine they would find the situation frustrating to deal with if you had not tried them first, but there are other lipid lowering drugs, even if statins are refused and it throws off their normal way of managing the problem with statins first. There are doctors that exist that do listen to patients concerns and are willing to treat problems even if they do not agree with the patients perspective.

 

[Lovedog100]

Hey guys Question............ ?? Are there any peptides to anyone's knowledge here that is helpful with cholesterol reduction or is that even a thing? Thank you in advance for any helpful information anyone can give.

Remember that we are all just giving our opinions. Some from internet research, others from their own experience. We aren't doctors, if there is a doctor here, he/she isn't your doctor. That said, I would stay away from statins, they are not good for your overall health. Reta does help with cholesterol. Also, there are non peptide options like supplements, teas, and some foods that help lower cholesterol. Punch the question into your Google search bar, or your YouTube search bar.

 

[drswole]

first hand experience fixing my lipids using Reta.

I went up to 6mg weekly at one stage, but found 4mg to be sweet spot.

It also didnt surpress appetite so much like semaglutide did to me, so i was able to keep protein intake up to save some muscle mass.

i went from

total fasting Cholsesterol 5mmol/L (range < 5.5)

trigs 2.2mmol/L (range < 2)

LDL 4.7mmol/L (range < 3)

to (in around 8months, inclusive of some supplements, fasting, increased cardio)

total fasting Cholsesterol 2.14mmol/L (range < 5.5)

trigs 0.58mmol/L (range < 2)

LDL 1.1mmol/L (range < 3)

So reta definitely works

 

[CathyGoesFar]

I'd be curious if you have any luck with that combo and could update later, Good luck!

Returning with an update after my quarterly bloodwork.

Modern science is f-ing amazing. I have not been the most consistent about taking my ezetimibe so I'm going to reset with a different pill holding thing(can't use common name because it autocorrects to vendor?) that keeps it separate and see how things improve at my next blood work in 3 months. Right now it's sitting in with meds I need to take with a meal when it can just be taken before bed without bothering about that. 150 drop of ldl is still excellent.

 

[Airborne Daddy]

It's ridiculous how often someone has to have a heart attack before they actually treat FH.

I'm going to push hard at my next appointment to get FH added to my conditions lists and request to see a lipid specialist. So far they have all acknowledged that I have it but continue to list "hyperlipidemia, unspecified" . I firmly meet diagnostic criteria.

I have always refused statins and then they end the conversation at that. No doctor has ever offered me other options. Pretty much "You don't want statins? Ok, F off and die". I have met people with permanent damage from statins so as long as other options exist I'm not doing it. It generally requires high doses or multiple types of statins to adequately lower LDL in FH and that means an increased risk of side effects. Repatha and ezetimibe are so far side effect free although trying to use the auto injector is such a PITA I'll probably pull it apart and self inject.

Just said this to my wife. Cardiologist blew me off and said if you dont have chest pain, shortness of breath, etc.... why are you even here? Toldem my abnormal ekg, right bundle blockage, calcification of my heart arteries noted on a scan and as soon as i fall asleep my hr hits 130 and stays there whenever im asleep. Explained i was being proactive. He wants nothing to do with me until something bad happens.

 

[RubbaDubba1]

Returning with an update after my quarterly bloodwork.

Modern science is f-ing amazing. I have not been the most consistent about taking my ezetimibe so I'm going to reset with a different pill holding thing(can't use common name because it autocorrects to vendor?) that keeps it separate and see how things improve at my next blood work in 3 months. Right now it's sitting in with meds I need to take with a meal when it can just be taken before bed without bothering about that. 150 drop of ldl is still excellent.

That's awesome, glad to see you got some positive results. Looks like, that's the play right now. No telling how good it'll get, once you start adulting correctly with the new pill container

 

[Whiynot20026]

I would think any pep that raises TES or HGH would inversely affect your cholesterol. It’s not possible to have high TES and HGH and have high cholesterol. They work opposite to each other.

Bill

 

[wildweasel]

I would think any pep that raises TES or HGH would inversely affect your cholesterol. It’s not possible to have high TES and HGH and have high cholesterol. They work opposite to each other.

Bill

Testosterone improves cholesterol?

Lmao do a google search or something buddy, you have no idea. Testosterone is extremely well known for significantly damaging cholesterol and lipid markers. There’s no shortage of medical literature showing this. It’s why people who inject test get regular lipid panels and why they develop artherosclerosis. FFS heart disease caused by cholesterol is the number one cause of early death in people who use testosterone, this is such a well-known documented fact

 

[Whiynot20026]

Testosterone improves cholesterol?

Lmao do a google search or something buddy, you have no idea. Testosterone is extremely well known for significantly damaging cholesterol and lipid markers. There’s no shortage of medical literature showing this. It’s why people who inject test get regular lipid panels and why they develop artherosclerosis. FFS heart disease caused by cholesterol is the number one cause of early death in people who use testosterone, this is such a well-known documented fact

My name is Bill. And yes. Cholesterol goes down when you have high Tes. Buddy. I have done my research. And I have done it with myself through fasting. It’s a well known fact. Impossible to be high on both. You are reducing chesterfield when building Tes.

Bill or buddy. I prefer Bill.

 

[Airborne Daddy]

Testosterone improves cholesterol?

Lmao do a google search or something buddy, you have no idea. Testosterone is extremely well known for significantly damaging cholesterol and lipid markers. There’s no shortage of medical literature showing this. It’s why people who inject test get regular lipid panels and why they develop artherosclerosis. FFS heart disease caused by cholesterol is the number one cause of early death in people who use testosterone, this is such a well-known documented fact

Agreed. Maybe he means severe hypogonadism cases where trt helped lipids partly and likely due to lifestyle changes. On 120mg a week my levels look great. Currently at 300mg test and 300 mast not so much... just wait till the tren gets added.... hdl 0, ldl 300

 

[wildweasel]

My name is Bill. And yes. Cholesterol goes down when you have high Tes. Buddy. I have done my research.

if you are claiming it lowers ldl (good cholesterol) and significantly worsens overall lipid profiles and contributes to heart disease you are correct

If you were trying to claim it improves cholesterol and lowers heart disease I have about half a dozen medical publications I can post right now if you’re interested that show you that’s incorrect.