Does anyone know the shelf life of these pills. I am acquiring some, but don't want to jump in straight away as tirz is still working, but curious how long I can just let them sit in the bottle.
Orforglipron: The next big thing?
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It's the "Wild West" out there. You're talking about a medication that hasn't been approved and released for retail being pressed into tablets with who-knows-what kind of fillers by the Chinese underground. Shelf life is whatever you feel comfortable with. Based on the shelf life of approved medications I know of, I'm sure they'll last at least a year or two before they start to lose potency. I doubt they'll degrade into some toxic compound or anything. But I can't guarantee thatdruell235 said:
GLP1Pharmacist said:
From what I see, the going rate seems to be similar to Uther's US warehouse pricing:
$197 (8mg x 100 pills)
And the traditional group buys (with all the patience and risk required) aren't really cheaper. About $20 less but third-party tested.
WWB has $195 for 12mg or $115 for 6mg so they seem to have the most competitive price.
That is similar to what SSA was charging for the same size and amount (100 pills). $185 for 12 mg and $105 for 6 mg.
Jack brown said:
Thanks again. Their US warehouse has it slightly more (understandably) at $220 for 12 mg and $135 for 6 mg.
Dang, they missing out - pinning is 1/2 the fun,Derby said:
Haha, but I asked Gemini and it confirmed my new concern:
"Orforglipron places a higher metabolic workload on the liver (first-pass metabolism) but has shown a good safety profile. Tirzepatide places a much lower metabolic workload on the liver."
"Orforglipron places a higher metabolic workload on the liver (first-pass metabolism) but has shown a good safety profile. Tirzepatide places a much lower metabolic workload on the liver."
WWB does not have a group on TG or Discord. They are pretty underground in that regard, but they are discussed a lot at Meso.
Their shipping cost from China starts at $50:
There is also a GB group that uses WWB, including the US warehouse of WWB. But no GBs currently since they just completed one.
Their shipping cost from China starts at $50:
quoted said:
There is also a GB group that uses WWB, including the US warehouse of WWB. But no GBs currently since they just completed one.
I doubt there are such studies yet, but it should be fine.
Obesity specialists have been adding metformin occasionally for some people already on a GLP, like when someone on sema or tirz wants a boost but can't raise the dose yet due to the dosing schedule.
Obesity specialists have been adding metformin occasionally for some people already on a GLP, like when someone on sema or tirz wants a boost but can't raise the dose yet due to the dosing schedule.
By the way, brand-name Jardiance is available from India.
Personally, I don't see the need for having Jardiance or metformin along with a GLP, since a GLP is much stronger. (My internist wanted me to increase the dose for tirz even weekly, if necessary.)
OTOH, metformin increases the body's natural production of GLP-1. So it may be good while on a strict dosing schedule. Like people tend to feel hungrier on day five of a weekly dose of tirz.
Personally, I don't see the need for having Jardiance or metformin along with a GLP, since a GLP is much stronger. (My internist wanted me to increase the dose for tirz even weekly, if necessary.)
OTOH, metformin increases the body's natural production of GLP-1. So it may be good while on a strict dosing schedule. Like people tend to feel hungrier on day five of a weekly dose of tirz.
Have you seen anything on skyrizy?Calm Logic said:
Okay thanksCalm Logic said:
the brand name goes for 19k :0
Yeah, I just noticed that and included the link to GoodRx. Insane.
druell235 said:
From an article on polypharmacy:
Why Do GLP-1 Drugs Stop Working, and What to Do About It?
Everybody has a set point, and every weight loss intervention eventually leads to a plateau, so it helps to have a variety of tools to support patients.
www.medscape.com
"You don't see this in the studies, which are focused on just one drug, but many of our patients are on combination therapy. They're on a GLP-1 drug plus phentermine/topiramate plus metformin, and more. They're usually on three, four, five drugs, similar to what we would see with resistant hypertension."
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