Orforglipron: The next big thing?

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A pill form of GLP1 and GIP agonist would be revolutionary. I don’t know if a pill form of glucagon will be possible though, so oral tirzepatide would be the first goal. Oral retatrutide would be the dream.
 
Derby said:
No. Comparing to a control group is required, but it doesn't have to be a placebo control group . It's 100% acceptable, even required, to compare a new treatment to the standard-of-care treatment.

For example, if I were testing a new oral medication for Type 2 DM, I might randomize the participants to receive either the new med or metformin, which would act as the control. It would be unethical to randomize them to a placebo when they have a serious disease with a known effective treatment. This is my argument for GLP-1Ras, too.
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We wouldn’t conduct a trial with a treatable form of cancer where we give a placebo. That would be unethical. Instead we use a conventional treatment and a treatment that we hope will work better.
 
I found a vendor selling Orforglipron raws. 1g for $290 so pretty expensive.

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The results of the ACHIEVE-1 trial are published in the NEJM. Bottom line looks like for weight loss it's not quite as effective as injectable semaglutide or tirzepatide, but certainly enough to make it a viable alternative to people who won't do shots.

https://www.nejm.org/doi/full/10.1056/NEJMoa2505669
 
keangkong said:
Does anyone sell orforglipron?
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I ran into it today on xcel for the first time. It costs 369.00 for 60 12mg capsules.
 
Derby said:
The results of the ACHIEVE-1 trial are published in the NEJM. Bottom line looks like for weight loss it's not quite as effective as injectable semaglutide or tirzepatide, but certainly enough to make it a viable alternative to people who won't do shots.

https://www.nejm.org/doi/full/10.1056/NEJMoa2505669
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That's a diabetes only trial though, where losses are generally less.

quoted said:
Participants had type 2 diabetes treated only with diet and exercise, a glycated hemoglobin level of at least 7.0% but no more than 9.5%, and a body-mass index (the weight in kilograms divided by the square of the height in meters) of at least 23.0
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Some of them were not even overweight.
 
dogmom said:
Has anyone tried this from a vendor?
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Got an email from Peptide Sciences that they are carrying this now. Also wondering if anyone else has tried this oral form?

I know a lot of people that would prefer capsules to injecting (even if it isn't as efficacious).
 
m100568 said:
Novo Nordisk is working on a pill form of Semaglutide using their "SNAC" technology. The recent news about Amycretin was also encouraging, although still in early trials. I agree that pills will be the preferred method of administration for most people. This would mean easier production, distribution and storage. Unfortunately, I am less optimistic that Novo or Evil Lilly would charge any less for the pills. We need competition from more companies, not just a different form of the medication.
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If the drug costs less to make , store , transport and distribute the price will be lower. More so if there are multiple oral drugs on the market. In fact they may be able to make MORE money charging less. The vast majority of Americans aren’t able to afford the current price structure. 50% profit levels on 10 sales are a lot better than 200% profit levels on 1.

There are 104 million obese Americans. And 86 million overweight. Around 15 million are on glp 1 drugs ( legit scripts ) currently. The drug companies could sell a LOT more at a lower price point. And they are going to have to in a few years when patents expire.
 
Blitziod said:
If the drug costs less to make , store , transport and distribute the price will be lower. More so if there are multiple oral drugs on the market. In fact they may be able to make MORE money charging less. The vast majority of Americans aren’t able to afford the current price structure. 50% profit levels on 10 sales are a lot better than 200% profit levels on 1.

There are 104 million obese Americans. And 86 million overweight. Around 15 million are on glp 1 drugs ( legit scripts ) currently. The drug companies could sell a LOT more at a lower price point. And they are going to have to in a few years when patents expire.
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Agreed. Over time the prices will fall. Granted I’m not paying much now thanks to Chinese vendors.
 
No thanks to a pill form of anything. I have to think about my tirz once a week for about five minutes, and then I get to just go about my business. If I could stick my thyroid medicine, my vitamins, and all my other meds into a syringe, do it once a week, and spend the whole rest of the week never trying to remember to go swallow a pill, I'd be thrilled.
 
randompersonrandom said:
No thanks to a pill form of anything. I have to think about my tirz once a week for about five minutes, and then I get to just go about my business. If I could stick my thyroid medicine, my vitamins, and all my other meds into a syringe, do it once a week, and spend the whole rest of the week never trying to remember to go swallow a pill, I'd be thrilled.
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I'm not sure I actually prefer an injection to pills, however, I don't mind injecting myself enough to tolerate worse results with pills. I do realize that large numbers of folks do have problems with injecting themselves. I though I had a problem with injecting myself too as I spent about an hour preparing to inject myself for the first time. Then I injected myself. It was actually rather funny; after all that worry, it turned out to be nothing (for me).
 
keangkong said:
I though I had a problem with injecting myself too as I spent about an hour preparing to inject myself for the first time. Then I injected myself. It was actually rather funny; after all that worry, it turned out to be nothing (for me).
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GIRL SAME! (or boy same) SO SAME! I thought it was gonna hurt, gonna be scary, gonna be complicated, and then "Oh. Now I'm done? for a WEEK???"
 
I had nightmares about stabbing myself after my first injection. I kinda like pinning myself now. I also had nightmares when I first got contacts. I still don't really like putting those in and taking them out.
 
vewdew34 said:
Yes SSA got it on the new list.
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I noticed they have Tirz in pill form. Anyone have info on this? is it effective? Has anyone given it to their rats yet?
 
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