I’m also curious because I too am at 15 mg and I feel like the effects have worn off. Not sure where to go from here.When_Pigs_Fly said:
Not Good - Gaining on 15 mg Tirz
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Same thing here, down to 210, now back to 230, pushing max does of tirz.
Debating starting 15+MG of tirz with a small reta dose. Problem is, I was on sole reta for a while and it did work but gave an insane amounts of "blah" to life. So I basically need to stay low dose reta and high dose tirz I think....
Its an experiment.
Debating starting 15+MG of tirz with a small reta dose. Problem is, I was on sole reta for a while and it did work but gave an insane amounts of "blah" to life. So I basically need to stay low dose reta and high dose tirz I think....
Its an experiment.
20lb rebound is significant. Did you change your supplier?TheAnonOne said:
I would definitely add reta..
If it was as simple as calories in vs calories out, I’d be a skinny legend by now.
Sometimes I think folks forget that these drugs help people with metabolic disease finally start to see results from the actions they have consistently taken.
Sometimes I think folks forget that these drugs help people with metabolic disease finally start to see results from the actions they have consistently taken.
My experience? The progress on Sema has been slow but steady.When_Pigs_Fly said:
My husband is a different story, unfortunately. He also lost weight on Ozempic but started getting sloppy with his eating habits and has put it back on again.
I don’t micromanage him. He a grown man who is prescribed the Ozempic by his doc. But, I live with the dude, yanno? I see what he eats, and what his body looks like. Just like he sees what I eat and what my body looks like.
Sema for me hasn’t been a journey where I inject and the weight magically disappears. It’s taken work. And still takes work. I still mess up.
This. This right here.Stace_wow said:
It is not CICO. The conventional wisdom is incorrect.
I have no doubt, I could not do it on my own.
Without Tirz, I would still be overweight. I tried many diets..Low Fat, Low Carb, Low Cal, you name it...
Tirz was what I needed to let my brain stop thinking of food.
When I started a new diet, I would think about what do i need to buy for my cupboard?
Meal planning, etc..
Tirz stopped that.
However, all of the studies have 1 thing in common:
Calorie reduction.
You don't eat because you don't want to.
But if you are not counting and the scale is not moving, you might want to check if your eating too many calories.
Without Tirz, I would still be overweight. I tried many diets..Low Fat, Low Carb, Low Cal, you name it...
Tirz was what I needed to let my brain stop thinking of food.
When I started a new diet, I would think about what do i need to buy for my cupboard?
Meal planning, etc..
Tirz stopped that.
However, all of the studies have 1 thing in common:
Calorie reduction.
You don't eat because you don't want to.
But if you are not counting and the scale is not moving, you might want to check if your eating too many calories.
quoted said:
quoted said:
My fear is that if I dont get retatrutide, all my progress will be lost.Skidude said:
If I recall, you are doing TRT. When I started TRT I had an uptick in weight gain. It made me hungry and I ate more. It may also have added water weight.lastresort said:
As I balanced my levels and added some resistance, that went back down.
I have no aversion to using Reta if Tirz stops working, or adding it as a stack for the glucagon benefit.
I trust the drug to work, it has for almost 2 years, and I weighed in again at 164 on Thursday.
I have not counted a calorie in over a year, I just pay attention to nutrition and make sure to get my protein and fiber.
between hitting goal in april 2025, starting trt june 25 and novemeber 25 my weight ticked up.
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This is the part no one wants to talk about. These are not magic pills and shots. Plenty of work goes into positive results.4StrandKnot said:
I was reading on another forum today, someone complaining that they had been on Tirz for 8 months and not lost a pound. I don't even know where you start with a comment this goofy. Who stays on a diet for 8 months with absolutely zero results. I review my weight daily and adjust as needed and reflect on the prior day's actions.
When my PCP first prescribed my meds, not one word on diet or exercise was mentioned. I'm not stupid and understand that today we don't have magic fat burning pills.
Congratulations on your success.
I would say my Tirz was more than magic, it was miraculous!Seasonal1 said:
That's why I go to so much effort to ensure I never run out.
I did, however, force myself to get my steps in; even on days I was tired it did not want to do it. I also eliminated most refined sugars and fats for the first 7 months.
Now, I am pretty casual with my program, Tirz is doing all of the heavy lifting.
In all fairness, different people respond differently to GLP1s, some the weight falls off with little effort, some have a tougher time and have to find the right mix.
There are also mimetics that can be stacked to benefit weight loss.
Reta, does have the added benefit of "burning", so arguably also pretty magic
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Very nice!Skidude said:
I wonder if this phenomenon is more common among women. Certainly men are loudest (and most certain) when denying it's real. Evidently it's inconceivable that someone would have an experience they're not familiar with.HereKittyKitty said:
I, for one, recognize that CICO has it's issues; you should never count calories out when targeting BMR.AngieHolmes said:
Another challenge is accurately measuring calories, as well as adjusting BMR as you lose weight.
I am not sure we need to bring gender into the debate, but I did provide data on how Lilly was targeting less calories in order to lose weight.
Whether you are able to target BMR on individual metabolizing performance, may be a subject of controversy; but there is little controversy in the fact that if you eat too much you will gain weight.
I see comments like this fairly often -- people taking the top dose of their med for months at a time without any loss. It's mystifying. They're wondering if they should stack something else. That usually generates discussion around whether we build a tolerance to the meds ("impossible!"), or whether the person isn't being honest with themselves about how much they're consuming (rude, IMO).Seasonal1 said:
I think the fact is we don't understand everything about these meds. Sometimes the most we can expect from the top dose is maintaining. It feels like the drug is doing nothing, but how much would we have gained without it?
Adjusting my diet/exercise/med regimen on a single day's data has never been useful for me but if it works for you, more power to ya! I need a longer period of time to detect real patterns.
If you are having to count calories and deliberately restrict calorie intake over a long period while taking GLP drugs for them to work, then they are not really working or at best maybe helping a bit. The reason I think it is a problem is that voluntary calorie restriction takes effort , and in general it is not really sustainable, basically turning the process back into a low calorie diet, which might work for a while but generally has poor long term success rates.
Th GLP drugs are meant to reduce appetite so you eat less and create a calorie deficit, without requiring willpower, this is basically why they work long term. And if they do not have that effect at decent doses, and the only way to lose weight is to deliberately restrict calories, then most likely you are one of the unfortunate 5-10% who respond poorly to them.
A lot of people use GLP drugs like a standard diet and exercise program, at low doses with poor hunger control, and deliberate calorie restriction, and set themselves up for a high risk of losing a lot less weight or putting it back on once tolerating the hunger gets too hard in the longer term. So when I see responses to people not losing weight or much weight on them that recommend calorie counting and more exercise as the solution, I tend to disagree, not that they are a bad idea as such, just that they do not really work for long term weight control, especially for those with more severe obesity.
Th GLP drugs are meant to reduce appetite so you eat less and create a calorie deficit, without requiring willpower, this is basically why they work long term. And if they do not have that effect at decent doses, and the only way to lose weight is to deliberately restrict calories, then most likely you are one of the unfortunate 5-10% who respond poorly to them.
A lot of people use GLP drugs like a standard diet and exercise program, at low doses with poor hunger control, and deliberate calorie restriction, and set themselves up for a high risk of losing a lot less weight or putting it back on once tolerating the hunger gets too hard in the longer term. So when I see responses to people not losing weight or much weight on them that recommend calorie counting and more exercise as the solution, I tend to disagree, not that they are a bad idea as such, just that they do not really work for long term weight control, especially for those with more severe obesity.
I do believe that is the case for me, I eat whatever I want and have not counted calories for over a year. Sometimes Ice cream, often chorizo and eggs with cheese, a nice steak, there is nothing off the menu. I just try to be smart about nutrition, protein, and fiber.lessthanhalf said:
However I am not gaining weight.
If you are gaining weight you might want to check your caloric intake.
I must be the anomaly. I have to work my ass off…..the tirz helps the food noise, but my weight loss is slow. 
Please do not misunderstand, when I wanted to lose weight, I counted and I walked.Stace_wow said:I must be the anomaly. I have to work my ass off…..the tirz helps the food noise, but my weight loss is slow.
Once I hit my goal, I did not want to lose, so I take my 15mg a week and it is enough to keep me from gaining. I get full easier and don't overdo it, because I know it will upset my stomach if I go overboard.
I was on intermittent fasting 16/8 with a 1200 daily calorie target, and a goal of 10k steps a day.
I also had daily protein and fiber targets as well as water and electrolytes EOD. That gave me a 27% loss in 7 months or a total of 63lbs. No way I could do that without Tirz, and I am lucky that I responded well to it, some are not as lucky and I recognize that.
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