New quintuple agonist from Eli lilly! So new it is not yet named.

[nukatide]

View: https://youtube.com/shorts/SNsfuu5V8nU?si=KwtxDgSRwdtkJ4Y9

No name for it apparently. But it looks like Ely lilly is focusing on satiety and bone health. I was wondering if anyone had heard of Amylin or Calcitonin? Those are apparently the new additions on top of the benefits from GLP1, GIP and Glucagon found in Retatrutide.

After some very surface level research Amylin seems to offer satiety similar to Cagrilintide. Amylin also slows gastric emptying further, boosts bone metabolism (which is basically just the tissues in your bones remodeling to improve skeletal strength) and the weirdest thing Amylin does is suppress Glucagon. I think its weird because Glucagon is literally in the same product. My thought is that shutting off Glucagon is not a benefit of Amylin but rather just something that happens. I believe Glucagon is produced naturally during fasting or heavy excercise. Because you are supplementing Glucagon your going to continue with the benefits of Glucagon. Calcitonin basically signals your body to lower calcium in the blood and protect bone density.

 

[woundcarping]

Amylin like Cag or Eloralintide?

 

[nukatide]

from the very surface level research I have seen, the Amylin does offer satiety like cagrilintide.

 

[geoguy78]

After some very surface level research Amylin seems to offer satiety similar to Cagrilintide.

That's because cagrilintide IS amylin (it's technically an amylin analog). It's just been altered to be longer lasting. But for all intents and purposes they are one and the same

 

[thorien]

They will no doubt try and get this classified as a biologic also - got to protect those profit margins !

 

[Rolltide61]

This needs to be forwarded on to the vendors right away so they can steal it. It's our responsibility to do it.

 

[tubby]

This needs to be forwarded on to the vendors right away so they can steal it. It's our responsibility to do it.

You're far braver than I am. As the structures get more and more complex, my confidence that random Chinese labs can effectively synthesize it (vs an isomer that passes for it via standard testing but is ultimately a different molecule) drops lower and lower. In an environment where the producer of the API is obscured by the vendors (who are buying from finishers procuring the cheapest APIs that will pass lab tests), even if you found a reliable source, that could vary from batch to batch a given vendor sells.

 

[Devilseye]

View: https://youtube.com/shorts/SNsfuu5V8nU?si=KwtxDgSRwdtkJ4Y9

No name for it apparently. But it looks like Ely lilly is focusing on satiety and bone health. I was wondering if anyone had heard of Amylin or Calcitonin? Those are apparently the new additions on top of the benefits from GLP1, GIP and Glucagon found in Retatrutide.

After some very surface level research Amylin seems to offer satiety similar to Cagrilintide. Amylin also slows gastric emptying further, boosts bone metabolism (which is basically just the tissues in your bones remodeling to improve skeletal strength) and the weirdest thing Amylin does is suppress Glucagon. I think its weird because Glucagon is literally in the same product. My thought is that shutting off Glucagon is not a benefit of Amylin but rather just something that happens. I believe Glucagon is produced naturally during fasting or heavy excercise. Because you are supplementing Glucagon your going to continue with the benefits of Glucagon. Calcitonin basically signals your body to lower calcium in the blood and protect bone density.

I mean the whole quintuple agonist is more of a marketing gimmick as calcitonin agonism means nothing for weight loss, if anything it may hamper it.

For example, cagri is a double agonist to amylin 1/3 and calcitonin but is about 50% as effective for weight loss as eloralintide which is 100% specific to amylin 1/3. So calcitonin both biochemically and clinically is irrelevant to this discussion.

Still the molecule is interesting. I wonder how they managed that as the structures of amylin and glp-1/gip/gcgr are very different. Would be interesting to see that in a crystal structure.

 

[Devilseye]

You're far braver than I am. As the structures get more and more complex, my confidence that random Chinese labs can effectively synthesize it (vs an isomer that passes for it via standard testing but is ultimately a different molecule) drops lower and lower. In an environment where the producer of the API is obscured by the vendors (who are buying from finishers procuring the cheapest APIs that will pass lab tests), even if you found a reliable source, that could vary from batch to batch a given vendor sells.

Yeah i agree. I mean there is a stereocenter in reta/tirz if im not mistaken which you wont detect in a mass spec like you mention. So for all we know we may all be getting a racemic mixture. I have no clue. If someone knows more about this id be keen on learning.

May also be why eloralintide is not on the market? Many more non natural amino acids, stereocenters and a disulfide bond. I have no clue. Cagri also has a disulfide bond and it doesnt seem to be a problem there. If someone knows why please enlighten me!